Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation
Background Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint (TMJ) inflammation and pathology biomarker research. No comparison of TMJ protein content between synovial fluid an...
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| Veröffentlicht in: | Journal of oral rehabilitation 2022-06, Vol.49 (6), p.599-607 |
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| creator | Ulmner, Mattias Sugars, Rachael Naimi‐Akbar, Aron Alstergren, Per Lund, Bodil |
| description | Background
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint (TMJ) inflammation and pathology biomarker research. No comparison of TMJ protein content between synovial fluid and synovial tissue has been made.
Objectives
The aim of this study was to investigate whether cytokine concentrations in synovial fluid can be related to cytokine concentrations in synovial tissue and to analyse correlation of clinical parameters reflecting local inflammation to cytokine concentrations.
Methods
Synovial tissue and fluid samples were obtained during the same surgical procedure from a cohort of 101 patients with TMJ disorders. Interleukin (IL) 1β, IL‐6, IL‐8, IL‐10 and tumour necrosis factor α (TNF‐α) were analysed in the samples and an intraindividual correlation made. Various patient‐specific factors related to TMJ inflammation were associated with the cytokine concentrations in synovial fluid and tissue.
Results
No correlation between cytokine concentration in synovial fluid and synovial tissue was found, except for IL‐8 (ρ = .284, p = .024). Synovial tissue cytokines correlated strongly to inflammation‐related factors: diagnosis (IL‐1β, p = .001; TNF‐α, p = .000; IL‐10, p = .000), TMJ palpation pain (IL‐1β, p = .024; TNF‐α, p = .025), synovitis score (IL‐1β, p = .015) and subjective TMJ pain (TNF‐α, p = .016). Synovial fluid cytokines showed no significant relations to inflammation.
Conclusions
The investigated cytokine concentrations showed weak correlations between synovial fluid and synovial tissue, besides IL‐8. Synovial tissue appeared to reflect inflammation to a higher extent than synovial fluid. Thus, suggesting that synovial tissue research should complement synovial fluid in future explorations of TMJ pathology and inflammation.
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint inflammation and pathology biomarker research. In this study, cytokine concentrations in synovial tissue and synovial fluid samples were analysed and compared. No correlation between cytokine concentrations were found except for interleukin 8. Furthermore, clinical signs of inflammation were found to be associated with cytokine concentration in synovial tissue but not to synovial fluid. |
| doi_str_mv | 10.1111/joor.13321 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_454494</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2659475381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6231-5c80e09a8773f4fdd1c43b73668c8d51575ef47737c8394001d3e4f4b2a9a5873</originalsourceid><addsrcrecordid>eNqdkk1v1DAQhi0Eokvhwg9Akbgg1BR_x75UqhYoRZVWQoAQF8ubOMVbx17spNX-e5zN9gupHPDFHs_zzozHA8BLBA9RXu9WIcRDRAhGj8AMEc5KLCh-DGaQQFYigX_sgWcprSCEgrDqKdgjjFAsKzYDP-ebPlxYb1JhfdGbbh1i6LRv7HJwOharYH1fpI0Pl1a7onWDbYrsLnqb0mBGUTRO9zZkdchm63TXbe3n4EmrXTIvdvs--Pbxw9f5p_JscXI6Pz4ra44JKlktoIFSi6oiLW2bBtWULCvCuahFwxCrmGlpdla1IJJCiBpiaEuXWEvNREX2QTnFTVdmPSzVOtpOx40K2qrd1UU-GUUZpZJmXj7Ir2NobkXXQnzdr__QIioxZ3yrPXhQ-95-P1YhnqtOD4ohiMZnHU14ZjvT1Mb3Ubv7Ge95vP2lzsOlkgQzysd8b3YBYvg9mNSrzqbaOKe9CUNSmFNKOGZIZPT1X-gqDNHnX8sUkzRXL1Cm3k5UHUNK0bQ3xSCoxklU4ySq7SRm-NXd8m_QO61EE3Blndn8I5T6vFh8mYL-AZJI7Pg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2659475381</pqid></control><display><type>article</type><title>Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation</title><source>SWEPUB Freely available online</source><source>Access via Wiley Online Library</source><creator>Ulmner, Mattias ; Sugars, Rachael ; Naimi‐Akbar, Aron ; Alstergren, Per ; Lund, Bodil</creator><creatorcontrib>Ulmner, Mattias ; Sugars, Rachael ; Naimi‐Akbar, Aron ; Alstergren, Per ; Lund, Bodil</creatorcontrib><description>Background
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint (TMJ) inflammation and pathology biomarker research. No comparison of TMJ protein content between synovial fluid and synovial tissue has been made.
Objectives
The aim of this study was to investigate whether cytokine concentrations in synovial fluid can be related to cytokine concentrations in synovial tissue and to analyse correlation of clinical parameters reflecting local inflammation to cytokine concentrations.
Methods
Synovial tissue and fluid samples were obtained during the same surgical procedure from a cohort of 101 patients with TMJ disorders. Interleukin (IL) 1β, IL‐6, IL‐8, IL‐10 and tumour necrosis factor α (TNF‐α) were analysed in the samples and an intraindividual correlation made. Various patient‐specific factors related to TMJ inflammation were associated with the cytokine concentrations in synovial fluid and tissue.
Results
No correlation between cytokine concentration in synovial fluid and synovial tissue was found, except for IL‐8 (ρ = .284, p = .024). Synovial tissue cytokines correlated strongly to inflammation‐related factors: diagnosis (IL‐1β, p = .001; TNF‐α, p = .000; IL‐10, p = .000), TMJ palpation pain (IL‐1β, p = .024; TNF‐α, p = .025), synovitis score (IL‐1β, p = .015) and subjective TMJ pain (TNF‐α, p = .016). Synovial fluid cytokines showed no significant relations to inflammation.
Conclusions
The investigated cytokine concentrations showed weak correlations between synovial fluid and synovial tissue, besides IL‐8. Synovial tissue appeared to reflect inflammation to a higher extent than synovial fluid. Thus, suggesting that synovial tissue research should complement synovial fluid in future explorations of TMJ pathology and inflammation.
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint inflammation and pathology biomarker research. In this study, cytokine concentrations in synovial tissue and synovial fluid samples were analysed and compared. No correlation between cytokine concentrations were found except for interleukin 8. Furthermore, clinical signs of inflammation were found to be associated with cytokine concentration in synovial tissue but not to synovial fluid.</description><identifier>ISSN: 0305-182X</identifier><identifier>ISSN: 1365-2842</identifier><identifier>EISSN: 1365-2842</identifier><identifier>DOI: 10.1111/joor.13321</identifier><identifier>PMID: 35342975</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Biomarkers ; Cytokines ; Inflammation ; Interleukin 6 ; Interleukins ; Joint diseases ; Medicin och hälsovetenskap ; Original ; Pain ; Pathology ; Patients ; Synovial Fluid ; Synovial Membrane ; Synovitis ; Temporomandibular Joint ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Tumors</subject><ispartof>Journal of oral rehabilitation, 2022-06, Vol.49 (6), p.599-607</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2022 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6231-5c80e09a8773f4fdd1c43b73668c8d51575ef47737c8394001d3e4f4b2a9a5873</citedby><cites>FETCH-LOGICAL-c6231-5c80e09a8773f4fdd1c43b73668c8d51575ef47737c8394001d3e4f4b2a9a5873</cites><orcidid>0000-0002-9429-1771</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjoor.13321$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjoor.13321$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,553,781,785,886,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35342975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-51017$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:149265675$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:235342975$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ulmner, Mattias</creatorcontrib><creatorcontrib>Sugars, Rachael</creatorcontrib><creatorcontrib>Naimi‐Akbar, Aron</creatorcontrib><creatorcontrib>Alstergren, Per</creatorcontrib><creatorcontrib>Lund, Bodil</creatorcontrib><title>Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation</title><title>Journal of oral rehabilitation</title><addtitle>J Oral Rehabil</addtitle><description>Background
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint (TMJ) inflammation and pathology biomarker research. No comparison of TMJ protein content between synovial fluid and synovial tissue has been made.
Objectives
The aim of this study was to investigate whether cytokine concentrations in synovial fluid can be related to cytokine concentrations in synovial tissue and to analyse correlation of clinical parameters reflecting local inflammation to cytokine concentrations.
Methods
Synovial tissue and fluid samples were obtained during the same surgical procedure from a cohort of 101 patients with TMJ disorders. Interleukin (IL) 1β, IL‐6, IL‐8, IL‐10 and tumour necrosis factor α (TNF‐α) were analysed in the samples and an intraindividual correlation made. Various patient‐specific factors related to TMJ inflammation were associated with the cytokine concentrations in synovial fluid and tissue.
Results
No correlation between cytokine concentration in synovial fluid and synovial tissue was found, except for IL‐8 (ρ = .284, p = .024). Synovial tissue cytokines correlated strongly to inflammation‐related factors: diagnosis (IL‐1β, p = .001; TNF‐α, p = .000; IL‐10, p = .000), TMJ palpation pain (IL‐1β, p = .024; TNF‐α, p = .025), synovitis score (IL‐1β, p = .015) and subjective TMJ pain (TNF‐α, p = .016). Synovial fluid cytokines showed no significant relations to inflammation.
Conclusions
The investigated cytokine concentrations showed weak correlations between synovial fluid and synovial tissue, besides IL‐8. Synovial tissue appeared to reflect inflammation to a higher extent than synovial fluid. Thus, suggesting that synovial tissue research should complement synovial fluid in future explorations of TMJ pathology and inflammation.
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint inflammation and pathology biomarker research. In this study, cytokine concentrations in synovial tissue and synovial fluid samples were analysed and compared. No correlation between cytokine concentrations were found except for interleukin 8. Furthermore, clinical signs of inflammation were found to be associated with cytokine concentration in synovial tissue but not to synovial fluid.</description><subject>Biomarkers</subject><subject>Cytokines</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Joint diseases</subject><subject>Medicin och hälsovetenskap</subject><subject>Original</subject><subject>Pain</subject><subject>Pathology</subject><subject>Patients</subject><subject>Synovial Fluid</subject><subject>Synovial Membrane</subject><subject>Synovitis</subject><subject>Temporomandibular Joint</subject><subject>Tumor necrosis factor</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><issn>0305-182X</issn><issn>1365-2842</issn><issn>1365-2842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>D8T</sourceid><recordid>eNqdkk1v1DAQhi0Eokvhwg9Akbgg1BR_x75UqhYoRZVWQoAQF8ubOMVbx17spNX-e5zN9gupHPDFHs_zzozHA8BLBA9RXu9WIcRDRAhGj8AMEc5KLCh-DGaQQFYigX_sgWcprSCEgrDqKdgjjFAsKzYDP-ebPlxYb1JhfdGbbh1i6LRv7HJwOharYH1fpI0Pl1a7onWDbYrsLnqb0mBGUTRO9zZkdchm63TXbe3n4EmrXTIvdvs--Pbxw9f5p_JscXI6Pz4ra44JKlktoIFSi6oiLW2bBtWULCvCuahFwxCrmGlpdla1IJJCiBpiaEuXWEvNREX2QTnFTVdmPSzVOtpOx40K2qrd1UU-GUUZpZJmXj7Ir2NobkXXQnzdr__QIioxZ3yrPXhQ-95-P1YhnqtOD4ohiMZnHU14ZjvT1Mb3Ubv7Ge95vP2lzsOlkgQzysd8b3YBYvg9mNSrzqbaOKe9CUNSmFNKOGZIZPT1X-gqDNHnX8sUkzRXL1Cm3k5UHUNK0bQ3xSCoxklU4ySq7SRm-NXd8m_QO61EE3Blndn8I5T6vFh8mYL-AZJI7Pg</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Ulmner, Mattias</creator><creator>Sugars, Rachael</creator><creator>Naimi‐Akbar, Aron</creator><creator>Alstergren, Per</creator><creator>Lund, Bodil</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-9429-1771</orcidid></search><sort><creationdate>202206</creationdate><title>Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation</title><author>Ulmner, Mattias ; Sugars, Rachael ; Naimi‐Akbar, Aron ; Alstergren, Per ; Lund, Bodil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6231-5c80e09a8773f4fdd1c43b73668c8d51575ef47737c8394001d3e4f4b2a9a5873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomarkers</topic><topic>Cytokines</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Joint diseases</topic><topic>Medicin och hälsovetenskap</topic><topic>Original</topic><topic>Pain</topic><topic>Pathology</topic><topic>Patients</topic><topic>Synovial Fluid</topic><topic>Synovial Membrane</topic><topic>Synovitis</topic><topic>Temporomandibular Joint</topic><topic>Tumor necrosis factor</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulmner, Mattias</creatorcontrib><creatorcontrib>Sugars, Rachael</creatorcontrib><creatorcontrib>Naimi‐Akbar, Aron</creatorcontrib><creatorcontrib>Alstergren, Per</creatorcontrib><creatorcontrib>Lund, Bodil</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of oral rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulmner, Mattias</au><au>Sugars, Rachael</au><au>Naimi‐Akbar, Aron</au><au>Alstergren, Per</au><au>Lund, Bodil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation</atitle><jtitle>Journal of oral rehabilitation</jtitle><addtitle>J Oral Rehabil</addtitle><date>2022-06</date><risdate>2022</risdate><volume>49</volume><issue>6</issue><spage>599</spage><epage>607</epage><pages>599-607</pages><issn>0305-182X</issn><issn>1365-2842</issn><eissn>1365-2842</eissn><abstract>Background
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint (TMJ) inflammation and pathology biomarker research. No comparison of TMJ protein content between synovial fluid and synovial tissue has been made.
Objectives
The aim of this study was to investigate whether cytokine concentrations in synovial fluid can be related to cytokine concentrations in synovial tissue and to analyse correlation of clinical parameters reflecting local inflammation to cytokine concentrations.
Methods
Synovial tissue and fluid samples were obtained during the same surgical procedure from a cohort of 101 patients with TMJ disorders. Interleukin (IL) 1β, IL‐6, IL‐8, IL‐10 and tumour necrosis factor α (TNF‐α) were analysed in the samples and an intraindividual correlation made. Various patient‐specific factors related to TMJ inflammation were associated with the cytokine concentrations in synovial fluid and tissue.
Results
No correlation between cytokine concentration in synovial fluid and synovial tissue was found, except for IL‐8 (ρ = .284, p = .024). Synovial tissue cytokines correlated strongly to inflammation‐related factors: diagnosis (IL‐1β, p = .001; TNF‐α, p = .000; IL‐10, p = .000), TMJ palpation pain (IL‐1β, p = .024; TNF‐α, p = .025), synovitis score (IL‐1β, p = .015) and subjective TMJ pain (TNF‐α, p = .016). Synovial fluid cytokines showed no significant relations to inflammation.
Conclusions
The investigated cytokine concentrations showed weak correlations between synovial fluid and synovial tissue, besides IL‐8. Synovial tissue appeared to reflect inflammation to a higher extent than synovial fluid. Thus, suggesting that synovial tissue research should complement synovial fluid in future explorations of TMJ pathology and inflammation.
Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint inflammation and pathology biomarker research. In this study, cytokine concentrations in synovial tissue and synovial fluid samples were analysed and compared. No correlation between cytokine concentrations were found except for interleukin 8. Furthermore, clinical signs of inflammation were found to be associated with cytokine concentration in synovial tissue but not to synovial fluid.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35342975</pmid><doi>10.1111/joor.13321</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9429-1771</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Cytokines Inflammation Interleukin 6 Interleukins Joint diseases Medicin och hälsovetenskap Original Pain Pathology Patients Synovial Fluid Synovial Membrane Synovitis Temporomandibular Joint Tumor necrosis factor Tumor necrosis factor-TNF Tumors |
| title | Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation |
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