International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis
IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To...
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creator | van Huizen, Astrid M Gyulai, Rolland Warren, Richard B Egeberg, Alexander Kumar, Alur S Oakley, Amanda Ramos, Andrea Machado Coelho Fougerousse, Anne-Claire Horváth, Barbara Fábos, Béata Castro, Carla Ferrándiz, Carlos Goujon, Catherine Gonzalez, Cesar Maldonado-García, César Griffiths, Christopher E.M Vestergaard, Christian Conrad, Curdin Jullien, Denis Appelen, Diebrecht Kim, Dong Hyun de Jong, Elke M.G.J El Gamal, Emad Mahé, Emmanuel Sonkoly, Enikö Willaert, Fabienne Handjani, Farhad Vílchez-Márquez, Francisco Damiani, Giovanni Pellerano, Graciela Hunter, Hamish J. A Riad, Hassan Boonen, Hugo P.J Csányi, Ildíko Brajac, Ines Grozdev, Ivan Weinberg, Jeffrey M Nicolopoulos, Jenny Wells, Jillian Lambert, Jo L.W Prinz, Jörg Christoph de Souza Sittart, José Alexandre Castro-Ayarza, Juan Raul van den Reek, Juul M.P.A Trcko, Katarina Barber, Kirk Khobzei, Kuzma Fardet, Laurence le Cleach, Laurence Misery, Laurent Lecluse, Lidian Skov, Lone Frez, Ma. Lorna Babic, Lucija Tomic Dutil, Maha El-Sayed, Mahira Hamdy Olszewska, Malgorzata Schram, Mandy Elvira Llamas-Velasco, Mar Gonçalo, Margarida Velásquez-Lopera, Margarita M de Oliveira, Maria de Fátima Santos Paim Kaštelan, Marija Rademaker, Marius Sikora, Mariusz Lebwohl, Mark Wiseman, Marni C Ferran, Marta van Doorn, Martijn Danespazhooh, Maryam Bylaite-Bucinskiene, Matilda Gooderham, Melinda J Polic, Melita Vukšic Gómez-Flores, Minerva Salleras i Redonnet, Montse Yawalkar, Nikhil Cárdenas Rojas, Paola J Gisondi, Paolo Grewal, Parbeer Sator, Paul Luna, Paula Carolina Holló, Péter Calzavara-Pinton, Piergiacomo Ghislain, Pierre-Dominique Araujo, Raquel Ruiz Romiti, Ricardo Ceovic, Romana Vender, Ronald Lafuente-Urrez, Rosario Fátima Gulin, Sandra J Handa, Sanjeev Kolalapudi, Seetharam A Marrón, Servando E Azimi, Seyyede Zeinab Ayanlowo, Olusola Margasin, Susana M Hurtová, Tatiana Liu, Tong-Yun Leonidze, Tsira Veldkamp, Wendelien |
description | IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoria |
doi_str_mv | 10.1001/jamadermatol.2022.0434 |
format | Article |
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A ; Riad, Hassan ; Boonen, Hugo P.J ; Csányi, Ildíko ; Brajac, Ines ; Grozdev, Ivan ; Weinberg, Jeffrey M ; Nicolopoulos, Jenny ; Wells, Jillian ; Lambert, Jo L.W ; Prinz, Jörg Christoph ; de Souza Sittart, José Alexandre ; Castro-Ayarza, Juan Raul ; van den Reek, Juul M.P.A ; Trcko, Katarina ; Barber, Kirk ; Khobzei, Kuzma ; Fardet, Laurence ; le Cleach, Laurence ; Misery, Laurent ; Lecluse, Lidian ; Skov, Lone ; Frez, Ma. Lorna ; Babic, Lucija Tomic ; Dutil, Maha ; El-Sayed, Mahira Hamdy ; Olszewska, Malgorzata ; Schram, Mandy Elvira ; Llamas-Velasco, Mar ; Gonçalo, Margarida ; Velásquez-Lopera, Margarita M ; de Oliveira, Maria de Fátima Santos Paim ; Kaštelan, Marija ; Rademaker, Marius ; Sikora, Mariusz ; Lebwohl, Mark ; Wiseman, Marni C ; Ferran, Marta ; van Doorn, Martijn ; Danespazhooh, Maryam ; Bylaite-Bucinskiene, Matilda ; Gooderham, Melinda J ; Polic, Melita Vukšic ; Gómez-Flores, Minerva ; Salleras i Redonnet, Montse ; Yawalkar, Nikhil ; Cárdenas Rojas, Paola J ; Gisondi, Paolo ; Grewal, Parbeer ; Sator, Paul ; Luna, Paula Carolina ; Holló, Péter ; Calzavara-Pinton, Piergiacomo ; Ghislain, Pierre-Dominique ; Araujo, Raquel Ruiz ; Romiti, Ricardo ; Ceovic, Romana ; Vender, Ronald ; Lafuente-Urrez, Rosario Fátima ; Gulin, Sandra J ; Handa, Sanjeev ; Kolalapudi, Seetharam A ; Marrón, Servando E ; Azimi, Seyyede Zeinab ; Ayanlowo, Olusola ; Margasin, Susana M ; Hurtová, Tatiana ; Liu, Tong-Yun ; Leonidze, Tsira ; Veldkamp, Wendelien</creator><creatorcontrib>van Huizen, Astrid M ; Gyulai, Rolland ; Warren, Richard B ; Egeberg, Alexander ; Kumar, Alur S ; Oakley, Amanda ; Ramos, Andrea Machado Coelho ; Fougerousse, Anne-Claire ; Horváth, Barbara ; Fábos, Béata ; Castro, Carla ; Ferrándiz, Carlos ; Goujon, Catherine ; Gonzalez, Cesar ; Maldonado-García, César ; Griffiths, Christopher E.M ; Vestergaard, Christian ; Conrad, Curdin ; Jullien, Denis ; Appelen, Diebrecht ; Kim, Dong Hyun ; de Jong, Elke M.G.J ; El Gamal, Emad ; Mahé, Emmanuel ; Sonkoly, Enikö ; Willaert, Fabienne ; Handjani, Farhad ; Vílchez-Márquez, Francisco ; Damiani, Giovanni ; Pellerano, Graciela ; Hunter, Hamish J. A ; Riad, Hassan ; Boonen, Hugo P.J ; Csányi, Ildíko ; Brajac, Ines ; Grozdev, Ivan ; Weinberg, Jeffrey M ; Nicolopoulos, Jenny ; Wells, Jillian ; Lambert, Jo L.W ; Prinz, Jörg Christoph ; de Souza Sittart, José Alexandre ; Castro-Ayarza, Juan Raul ; van den Reek, Juul M.P.A ; Trcko, Katarina ; Barber, Kirk ; Khobzei, Kuzma ; Fardet, Laurence ; le Cleach, Laurence ; Misery, Laurent ; Lecluse, Lidian ; Skov, Lone ; Frez, Ma. Lorna ; Babic, Lucija Tomic ; Dutil, Maha ; El-Sayed, Mahira Hamdy ; Olszewska, Malgorzata ; Schram, Mandy Elvira ; Llamas-Velasco, Mar ; Gonçalo, Margarida ; Velásquez-Lopera, Margarita M ; de Oliveira, Maria de Fátima Santos Paim ; Kaštelan, Marija ; Rademaker, Marius ; Sikora, Mariusz ; Lebwohl, Mark ; Wiseman, Marni C ; Ferran, Marta ; van Doorn, Martijn ; Danespazhooh, Maryam ; Bylaite-Bucinskiene, Matilda ; Gooderham, Melinda J ; Polic, Melita Vukšic ; Gómez-Flores, Minerva ; Salleras i Redonnet, Montse ; Yawalkar, Nikhil ; Cárdenas Rojas, Paola J ; Gisondi, Paolo ; Grewal, Parbeer ; Sator, Paul ; Luna, Paula Carolina ; Holló, Péter ; Calzavara-Pinton, Piergiacomo ; Ghislain, Pierre-Dominique ; Araujo, Raquel Ruiz ; Romiti, Ricardo ; Ceovic, Romana ; Vender, Ronald ; Lafuente-Urrez, Rosario Fátima ; Gulin, Sandra J ; Handa, Sanjeev ; Kolalapudi, Seetharam A ; Marrón, Servando E ; Azimi, Seyyede Zeinab ; Ayanlowo, Olusola ; Margasin, Susana M ; Hurtová, Tatiana ; Liu, Tong-Yun ; Leonidze, Tsira ; Veldkamp, Wendelien ; SPIN MTX Consensus Survey Study Group</creatorcontrib><description>IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.</description><identifier>ISSN: 2168-6068</identifier><identifier>ISSN: 2168-6084</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/jamadermatol.2022.0434</identifier><identifier>PMID: 35353175</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adult ; Child ; Consensus ; Dermatology ; Folic Acid ; Humans ; Medical treatment ; Methotrexate ; Pediatrics ; Psoriasis ; Psoriasis - therapy ; Skin diseases ; Surveys and Questionnaires</subject><ispartof>Archives of dermatology (1960), 2022-05, Vol.158 (5), p.561-572</ispartof><rights>Copyright American Medical Association May 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a481t-ab6a80825e47e5b2cef8a600374a71015f65080b7f48fcb3d3b86aa79a9ff26e3</citedby><cites>FETCH-LOGICAL-a481t-ab6a80825e47e5b2cef8a600374a71015f65080b7f48fcb3d3b86aa79a9ff26e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/jamadermatol.2022.0434$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/jamadermatol.2022.0434$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,230,314,551,777,781,882,3327,27905,27906,76238,76241</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35353175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-475147$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:149228843$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>van Huizen, Astrid M</creatorcontrib><creatorcontrib>Gyulai, Rolland</creatorcontrib><creatorcontrib>Warren, Richard B</creatorcontrib><creatorcontrib>Egeberg, Alexander</creatorcontrib><creatorcontrib>Kumar, Alur S</creatorcontrib><creatorcontrib>Oakley, Amanda</creatorcontrib><creatorcontrib>Ramos, Andrea Machado Coelho</creatorcontrib><creatorcontrib>Fougerousse, Anne-Claire</creatorcontrib><creatorcontrib>Horváth, Barbara</creatorcontrib><creatorcontrib>Fábos, Béata</creatorcontrib><creatorcontrib>Castro, Carla</creatorcontrib><creatorcontrib>Ferrándiz, Carlos</creatorcontrib><creatorcontrib>Goujon, Catherine</creatorcontrib><creatorcontrib>Gonzalez, Cesar</creatorcontrib><creatorcontrib>Maldonado-García, César</creatorcontrib><creatorcontrib>Griffiths, Christopher E.M</creatorcontrib><creatorcontrib>Vestergaard, Christian</creatorcontrib><creatorcontrib>Conrad, Curdin</creatorcontrib><creatorcontrib>Jullien, Denis</creatorcontrib><creatorcontrib>Appelen, Diebrecht</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>de Jong, Elke M.G.J</creatorcontrib><creatorcontrib>El Gamal, Emad</creatorcontrib><creatorcontrib>Mahé, Emmanuel</creatorcontrib><creatorcontrib>Sonkoly, Enikö</creatorcontrib><creatorcontrib>Willaert, Fabienne</creatorcontrib><creatorcontrib>Handjani, Farhad</creatorcontrib><creatorcontrib>Vílchez-Márquez, Francisco</creatorcontrib><creatorcontrib>Damiani, Giovanni</creatorcontrib><creatorcontrib>Pellerano, Graciela</creatorcontrib><creatorcontrib>Hunter, Hamish J. A</creatorcontrib><creatorcontrib>Riad, Hassan</creatorcontrib><creatorcontrib>Boonen, Hugo P.J</creatorcontrib><creatorcontrib>Csányi, Ildíko</creatorcontrib><creatorcontrib>Brajac, Ines</creatorcontrib><creatorcontrib>Grozdev, Ivan</creatorcontrib><creatorcontrib>Weinberg, Jeffrey M</creatorcontrib><creatorcontrib>Nicolopoulos, Jenny</creatorcontrib><creatorcontrib>Wells, Jillian</creatorcontrib><creatorcontrib>Lambert, Jo L.W</creatorcontrib><creatorcontrib>Prinz, Jörg Christoph</creatorcontrib><creatorcontrib>de Souza Sittart, José Alexandre</creatorcontrib><creatorcontrib>Castro-Ayarza, Juan Raul</creatorcontrib><creatorcontrib>van den Reek, Juul M.P.A</creatorcontrib><creatorcontrib>Trcko, Katarina</creatorcontrib><creatorcontrib>Barber, Kirk</creatorcontrib><creatorcontrib>Khobzei, Kuzma</creatorcontrib><creatorcontrib>Fardet, Laurence</creatorcontrib><creatorcontrib>le Cleach, Laurence</creatorcontrib><creatorcontrib>Misery, Laurent</creatorcontrib><creatorcontrib>Lecluse, Lidian</creatorcontrib><creatorcontrib>Skov, Lone</creatorcontrib><creatorcontrib>Frez, Ma. Lorna</creatorcontrib><creatorcontrib>Babic, Lucija Tomic</creatorcontrib><creatorcontrib>Dutil, Maha</creatorcontrib><creatorcontrib>El-Sayed, Mahira Hamdy</creatorcontrib><creatorcontrib>Olszewska, Malgorzata</creatorcontrib><creatorcontrib>Schram, Mandy Elvira</creatorcontrib><creatorcontrib>Llamas-Velasco, Mar</creatorcontrib><creatorcontrib>Gonçalo, Margarida</creatorcontrib><creatorcontrib>Velásquez-Lopera, Margarita M</creatorcontrib><creatorcontrib>de Oliveira, Maria de Fátima Santos Paim</creatorcontrib><creatorcontrib>Kaštelan, Marija</creatorcontrib><creatorcontrib>Rademaker, Marius</creatorcontrib><creatorcontrib>Sikora, Mariusz</creatorcontrib><creatorcontrib>Lebwohl, Mark</creatorcontrib><creatorcontrib>Wiseman, Marni C</creatorcontrib><creatorcontrib>Ferran, Marta</creatorcontrib><creatorcontrib>van Doorn, Martijn</creatorcontrib><creatorcontrib>Danespazhooh, Maryam</creatorcontrib><creatorcontrib>Bylaite-Bucinskiene, Matilda</creatorcontrib><creatorcontrib>Gooderham, Melinda J</creatorcontrib><creatorcontrib>Polic, Melita Vukšic</creatorcontrib><creatorcontrib>Gómez-Flores, Minerva</creatorcontrib><creatorcontrib>Salleras i Redonnet, Montse</creatorcontrib><creatorcontrib>Yawalkar, Nikhil</creatorcontrib><creatorcontrib>Cárdenas Rojas, Paola J</creatorcontrib><creatorcontrib>Gisondi, Paolo</creatorcontrib><creatorcontrib>Grewal, Parbeer</creatorcontrib><creatorcontrib>Sator, Paul</creatorcontrib><creatorcontrib>Luna, Paula Carolina</creatorcontrib><creatorcontrib>Holló, Péter</creatorcontrib><creatorcontrib>Calzavara-Pinton, Piergiacomo</creatorcontrib><creatorcontrib>Ghislain, Pierre-Dominique</creatorcontrib><creatorcontrib>Araujo, Raquel Ruiz</creatorcontrib><creatorcontrib>Romiti, Ricardo</creatorcontrib><creatorcontrib>Ceovic, Romana</creatorcontrib><creatorcontrib>Vender, Ronald</creatorcontrib><creatorcontrib>Lafuente-Urrez, Rosario Fátima</creatorcontrib><creatorcontrib>Gulin, Sandra J</creatorcontrib><creatorcontrib>Handa, Sanjeev</creatorcontrib><creatorcontrib>Kolalapudi, Seetharam A</creatorcontrib><creatorcontrib>Marrón, Servando E</creatorcontrib><creatorcontrib>Azimi, Seyyede Zeinab</creatorcontrib><creatorcontrib>Ayanlowo, Olusola</creatorcontrib><creatorcontrib>Margasin, Susana M</creatorcontrib><creatorcontrib>Hurtová, Tatiana</creatorcontrib><creatorcontrib>Liu, Tong-Yun</creatorcontrib><creatorcontrib>Leonidze, Tsira</creatorcontrib><creatorcontrib>Veldkamp, Wendelien</creatorcontrib><creatorcontrib>SPIN MTX Consensus Survey Study Group</creatorcontrib><title>International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis</title><title>Archives of dermatology (1960)</title><addtitle>JAMA Dermatol</addtitle><description>IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.</description><subject>Adult</subject><subject>Child</subject><subject>Consensus</subject><subject>Dermatology</subject><subject>Folic Acid</subject><subject>Humans</subject><subject>Medical treatment</subject><subject>Methotrexate</subject><subject>Pediatrics</subject><subject>Psoriasis</subject><subject>Psoriasis - therapy</subject><subject>Skin diseases</subject><subject>Surveys and Questionnaires</subject><issn>2168-6068</issn><issn>2168-6084</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kUtvGyEUhVHVqonc_IEuIqRuOy4wDOBlZPcRKVWjPpfojn3HgzsDDjBq8--LZdfqprDgCr5zdLmHkGvO5pwx_mYHI2wwjpDDMBdMiDmTtXxCLgVXplLMyKfnWpkLcpXSjpVlWOH4c3JRN2Vz3VyS4dZnjB6yCx4Giisc9r2jX_K0eaQ50M8I654ug0_o05Ro8DT3SD9i7kOO-Bsy0lVIzm8LunUjeuo8vS9-6HOiP1zu6X0K0UFy6QV51sGQ8Op0zsi3d2-_Lj9Ud5_e3y5v7iqQhucKWgWGGdGg1Ni0Yo2dAcVYrSVoznjTqab8pdWdNN26rTd1axSAXsCi64TCekaqo2_6hfuptfvoRoiPNoCzp6ufpUIrGymFLvzr__Ir9_3Ghri102Slbrg84K-O-D6GhwlTtrswlRkOyQqltGlqXcY7I-pIrWNIKWJ3tuXMHmK0_8ZoDzHaQ4xFeH2yn9oRN2fZ39AK8PIIFP35VegFq0tzfwDCPaY8</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>van Huizen, Astrid M</creator><creator>Gyulai, Rolland</creator><creator>Warren, Richard B</creator><creator>Egeberg, Alexander</creator><creator>Kumar, Alur S</creator><creator>Oakley, Amanda</creator><creator>Ramos, Andrea Machado Coelho</creator><creator>Fougerousse, Anne-Claire</creator><creator>Horváth, Barbara</creator><creator>Fábos, Béata</creator><creator>Castro, Carla</creator><creator>Ferrándiz, Carlos</creator><creator>Goujon, Catherine</creator><creator>Gonzalez, Cesar</creator><creator>Maldonado-García, César</creator><creator>Griffiths, Christopher E.M</creator><creator>Vestergaard, Christian</creator><creator>Conrad, Curdin</creator><creator>Jullien, Denis</creator><creator>Appelen, Diebrecht</creator><creator>Kim, Dong Hyun</creator><creator>de Jong, Elke M.G.J</creator><creator>El Gamal, Emad</creator><creator>Mahé, Emmanuel</creator><creator>Sonkoly, Enikö</creator><creator>Willaert, Fabienne</creator><creator>Handjani, Farhad</creator><creator>Vílchez-Márquez, Francisco</creator><creator>Damiani, Giovanni</creator><creator>Pellerano, Graciela</creator><creator>Hunter, Hamish J. 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A ; Riad, Hassan ; Boonen, Hugo P.J ; Csányi, Ildíko ; Brajac, Ines ; Grozdev, Ivan ; Weinberg, Jeffrey M ; Nicolopoulos, Jenny ; Wells, Jillian ; Lambert, Jo L.W ; Prinz, Jörg Christoph ; de Souza Sittart, José Alexandre ; Castro-Ayarza, Juan Raul ; van den Reek, Juul M.P.A ; Trcko, Katarina ; Barber, Kirk ; Khobzei, Kuzma ; Fardet, Laurence ; le Cleach, Laurence ; Misery, Laurent ; Lecluse, Lidian ; Skov, Lone ; Frez, Ma. Lorna ; Babic, Lucija Tomic ; Dutil, Maha ; El-Sayed, Mahira Hamdy ; Olszewska, Malgorzata ; Schram, Mandy Elvira ; Llamas-Velasco, Mar ; Gonçalo, Margarida ; Velásquez-Lopera, Margarita M ; de Oliveira, Maria de Fátima Santos Paim ; Kaštelan, Marija ; Rademaker, Marius ; Sikora, Mariusz ; Lebwohl, Mark ; Wiseman, Marni C ; Ferran, Marta ; van Doorn, Martijn ; Danespazhooh, Maryam ; Bylaite-Bucinskiene, Matilda ; Gooderham, Melinda J ; Polic, Melita Vukšic ; Gómez-Flores, Minerva ; Salleras i Redonnet, Montse ; Yawalkar, Nikhil ; Cárdenas Rojas, Paola J ; Gisondi, Paolo ; Grewal, Parbeer ; Sator, Paul ; Luna, Paula Carolina ; Holló, Péter ; Calzavara-Pinton, Piergiacomo ; Ghislain, Pierre-Dominique ; Araujo, Raquel Ruiz ; Romiti, Ricardo ; Ceovic, Romana ; Vender, Ronald ; Lafuente-Urrez, Rosario Fátima ; Gulin, Sandra J ; Handa, Sanjeev ; Kolalapudi, Seetharam A ; Marrón, Servando E ; Azimi, Seyyede Zeinab ; Ayanlowo, Olusola ; Margasin, Susana M ; Hurtová, Tatiana ; Liu, Tong-Yun ; Leonidze, Tsira ; Veldkamp, Wendelien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a481t-ab6a80825e47e5b2cef8a600374a71015f65080b7f48fcb3d3b86aa79a9ff26e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Child</topic><topic>Consensus</topic><topic>Dermatology</topic><topic>Folic Acid</topic><topic>Humans</topic><topic>Medical treatment</topic><topic>Methotrexate</topic><topic>Pediatrics</topic><topic>Psoriasis</topic><topic>Psoriasis - therapy</topic><topic>Skin diseases</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Huizen, Astrid M</creatorcontrib><creatorcontrib>Gyulai, Rolland</creatorcontrib><creatorcontrib>Warren, Richard B</creatorcontrib><creatorcontrib>Egeberg, Alexander</creatorcontrib><creatorcontrib>Kumar, Alur S</creatorcontrib><creatorcontrib>Oakley, Amanda</creatorcontrib><creatorcontrib>Ramos, Andrea Machado Coelho</creatorcontrib><creatorcontrib>Fougerousse, Anne-Claire</creatorcontrib><creatorcontrib>Horváth, Barbara</creatorcontrib><creatorcontrib>Fábos, Béata</creatorcontrib><creatorcontrib>Castro, Carla</creatorcontrib><creatorcontrib>Ferrándiz, Carlos</creatorcontrib><creatorcontrib>Goujon, Catherine</creatorcontrib><creatorcontrib>Gonzalez, Cesar</creatorcontrib><creatorcontrib>Maldonado-García, César</creatorcontrib><creatorcontrib>Griffiths, Christopher E.M</creatorcontrib><creatorcontrib>Vestergaard, Christian</creatorcontrib><creatorcontrib>Conrad, Curdin</creatorcontrib><creatorcontrib>Jullien, Denis</creatorcontrib><creatorcontrib>Appelen, Diebrecht</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>de Jong, Elke M.G.J</creatorcontrib><creatorcontrib>El Gamal, Emad</creatorcontrib><creatorcontrib>Mahé, Emmanuel</creatorcontrib><creatorcontrib>Sonkoly, Enikö</creatorcontrib><creatorcontrib>Willaert, Fabienne</creatorcontrib><creatorcontrib>Handjani, Farhad</creatorcontrib><creatorcontrib>Vílchez-Márquez, Francisco</creatorcontrib><creatorcontrib>Damiani, Giovanni</creatorcontrib><creatorcontrib>Pellerano, Graciela</creatorcontrib><creatorcontrib>Hunter, Hamish J. 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A</au><au>Riad, Hassan</au><au>Boonen, Hugo P.J</au><au>Csányi, Ildíko</au><au>Brajac, Ines</au><au>Grozdev, Ivan</au><au>Weinberg, Jeffrey M</au><au>Nicolopoulos, Jenny</au><au>Wells, Jillian</au><au>Lambert, Jo L.W</au><au>Prinz, Jörg Christoph</au><au>de Souza Sittart, José Alexandre</au><au>Castro-Ayarza, Juan Raul</au><au>van den Reek, Juul M.P.A</au><au>Trcko, Katarina</au><au>Barber, Kirk</au><au>Khobzei, Kuzma</au><au>Fardet, Laurence</au><au>le Cleach, Laurence</au><au>Misery, Laurent</au><au>Lecluse, Lidian</au><au>Skov, Lone</au><au>Frez, Ma. Lorna</au><au>Babic, Lucija Tomic</au><au>Dutil, Maha</au><au>El-Sayed, Mahira Hamdy</au><au>Olszewska, Malgorzata</au><au>Schram, Mandy Elvira</au><au>Llamas-Velasco, Mar</au><au>Gonçalo, Margarida</au><au>Velásquez-Lopera, Margarita M</au><au>de Oliveira, Maria de Fátima Santos Paim</au><au>Kaštelan, Marija</au><au>Rademaker, Marius</au><au>Sikora, Mariusz</au><au>Lebwohl, Mark</au><au>Wiseman, Marni C</au><au>Ferran, Marta</au><au>van Doorn, Martijn</au><au>Danespazhooh, Maryam</au><au>Bylaite-Bucinskiene, Matilda</au><au>Gooderham, Melinda J</au><au>Polic, Melita Vukšic</au><au>Gómez-Flores, Minerva</au><au>Salleras i Redonnet, Montse</au><au>Yawalkar, Nikhil</au><au>Cárdenas Rojas, Paola J</au><au>Gisondi, Paolo</au><au>Grewal, Parbeer</au><au>Sator, Paul</au><au>Luna, Paula Carolina</au><au>Holló, Péter</au><au>Calzavara-Pinton, Piergiacomo</au><au>Ghislain, Pierre-Dominique</au><au>Araujo, Raquel Ruiz</au><au>Romiti, Ricardo</au><au>Ceovic, Romana</au><au>Vender, Ronald</au><au>Lafuente-Urrez, Rosario Fátima</au><au>Gulin, Sandra J</au><au>Handa, Sanjeev</au><au>Kolalapudi, Seetharam A</au><au>Marrón, Servando E</au><au>Azimi, Seyyede Zeinab</au><au>Ayanlowo, Olusola</au><au>Margasin, Susana M</au><au>Hurtová, Tatiana</au><au>Liu, Tong-Yun</au><au>Leonidze, Tsira</au><au>Veldkamp, Wendelien</au><aucorp>SPIN MTX Consensus Survey Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>JAMA Dermatol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>158</volume><issue>5</issue><spage>561</spage><epage>572</epage><pages>561-572</pages><issn>2168-6068</issn><issn>2168-6084</issn><eissn>2168-6084</eissn><abstract>IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>35353175</pmid><doi>10.1001/jamadermatol.2022.0434</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; American Medical Association Journals; SWEPUB Freely available online |
subjects | Adult Child Consensus Dermatology Folic Acid Humans Medical treatment Methotrexate Pediatrics Psoriasis Psoriasis - therapy Skin diseases Surveys and Questionnaires |
title | International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis |
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