International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis

IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To...

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Veröffentlicht in:Archives of dermatology (1960) 2022-05, Vol.158 (5), p.561-572
Hauptverfasser: van Huizen, Astrid M, Gyulai, Rolland, Warren, Richard B, Egeberg, Alexander, Kumar, Alur S, Oakley, Amanda, Ramos, Andrea Machado Coelho, Fougerousse, Anne-Claire, Horváth, Barbara, Fábos, Béata, Castro, Carla, Ferrándiz, Carlos, Goujon, Catherine, Gonzalez, Cesar, Maldonado-García, César, Griffiths, Christopher E.M, Vestergaard, Christian, Conrad, Curdin, Jullien, Denis, Appelen, Diebrecht, Kim, Dong Hyun, de Jong, Elke M.G.J, El Gamal, Emad, Mahé, Emmanuel, Sonkoly, Enikö, Willaert, Fabienne, Handjani, Farhad, Vílchez-Márquez, Francisco, Damiani, Giovanni, Pellerano, Graciela, Hunter, Hamish J. A, Riad, Hassan, Boonen, Hugo P.J, Csányi, Ildíko, Brajac, Ines, Grozdev, Ivan, Weinberg, Jeffrey M, Nicolopoulos, Jenny, Wells, Jillian, Lambert, Jo L.W, Prinz, Jörg Christoph, de Souza Sittart, José Alexandre, Castro-Ayarza, Juan Raul, van den Reek, Juul M.P.A, Trcko, Katarina, Barber, Kirk, Khobzei, Kuzma, Fardet, Laurence, le Cleach, Laurence, Misery, Laurent, Lecluse, Lidian, Skov, Lone, Frez, Ma. Lorna, Babic, Lucija Tomic, Dutil, Maha, El-Sayed, Mahira Hamdy, Olszewska, Malgorzata, Schram, Mandy Elvira, Llamas-Velasco, Mar, Gonçalo, Margarida, Velásquez-Lopera, Margarita M, de Oliveira, Maria de Fátima Santos Paim, Kaštelan, Marija, Rademaker, Marius, Sikora, Mariusz, Lebwohl, Mark, Wiseman, Marni C, Ferran, Marta, van Doorn, Martijn, Danespazhooh, Maryam, Bylaite-Bucinskiene, Matilda, Gooderham, Melinda J, Polic, Melita Vukšic, Gómez-Flores, Minerva, Salleras i Redonnet, Montse, Yawalkar, Nikhil, Cárdenas Rojas, Paola J, Gisondi, Paolo, Grewal, Parbeer, Sator, Paul, Luna, Paula Carolina, Holló, Péter, Calzavara-Pinton, Piergiacomo, Ghislain, Pierre-Dominique, Araujo, Raquel Ruiz, Romiti, Ricardo, Ceovic, Romana, Vender, Ronald, Lafuente-Urrez, Rosario Fátima, Gulin, Sandra J, Handa, Sanjeev, Kolalapudi, Seetharam A, Marrón, Servando E, Azimi, Seyyede Zeinab, Ayanlowo, Olusola, Margasin, Susana M, Hurtová, Tatiana, Liu, Tong-Yun, Leonidze, Tsira, Veldkamp, Wendelien
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container_end_page 572
container_issue 5
container_start_page 561
container_title Archives of dermatology (1960)
container_volume 158
creator van Huizen, Astrid M
Gyulai, Rolland
Warren, Richard B
Egeberg, Alexander
Kumar, Alur S
Oakley, Amanda
Ramos, Andrea Machado Coelho
Fougerousse, Anne-Claire
Horváth, Barbara
Fábos, Béata
Castro, Carla
Ferrándiz, Carlos
Goujon, Catherine
Gonzalez, Cesar
Maldonado-García, César
Griffiths, Christopher E.M
Vestergaard, Christian
Conrad, Curdin
Jullien, Denis
Appelen, Diebrecht
Kim, Dong Hyun
de Jong, Elke M.G.J
El Gamal, Emad
Mahé, Emmanuel
Sonkoly, Enikö
Willaert, Fabienne
Handjani, Farhad
Vílchez-Márquez, Francisco
Damiani, Giovanni
Pellerano, Graciela
Hunter, Hamish J. A
Riad, Hassan
Boonen, Hugo P.J
Csányi, Ildíko
Brajac, Ines
Grozdev, Ivan
Weinberg, Jeffrey M
Nicolopoulos, Jenny
Wells, Jillian
Lambert, Jo L.W
Prinz, Jörg Christoph
de Souza Sittart, José Alexandre
Castro-Ayarza, Juan Raul
van den Reek, Juul M.P.A
Trcko, Katarina
Barber, Kirk
Khobzei, Kuzma
Fardet, Laurence
le Cleach, Laurence
Misery, Laurent
Lecluse, Lidian
Skov, Lone
Frez, Ma. Lorna
Babic, Lucija Tomic
Dutil, Maha
El-Sayed, Mahira Hamdy
Olszewska, Malgorzata
Schram, Mandy Elvira
Llamas-Velasco, Mar
Gonçalo, Margarida
Velásquez-Lopera, Margarita M
de Oliveira, Maria de Fátima Santos Paim
Kaštelan, Marija
Rademaker, Marius
Sikora, Mariusz
Lebwohl, Mark
Wiseman, Marni C
Ferran, Marta
van Doorn, Martijn
Danespazhooh, Maryam
Bylaite-Bucinskiene, Matilda
Gooderham, Melinda J
Polic, Melita Vukšic
Gómez-Flores, Minerva
Salleras i Redonnet, Montse
Yawalkar, Nikhil
Cárdenas Rojas, Paola J
Gisondi, Paolo
Grewal, Parbeer
Sator, Paul
Luna, Paula Carolina
Holló, Péter
Calzavara-Pinton, Piergiacomo
Ghislain, Pierre-Dominique
Araujo, Raquel Ruiz
Romiti, Ricardo
Ceovic, Romana
Vender, Ronald
Lafuente-Urrez, Rosario Fátima
Gulin, Sandra J
Handa, Sanjeev
Kolalapudi, Seetharam A
Marrón, Servando E
Azimi, Seyyede Zeinab
Ayanlowo, Olusola
Margasin, Susana M
Hurtová, Tatiana
Liu, Tong-Yun
Leonidze, Tsira
Veldkamp, Wendelien
description IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoria
doi_str_mv 10.1001/jamadermatol.2022.0434
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A ; Riad, Hassan ; Boonen, Hugo P.J ; Csányi, Ildíko ; Brajac, Ines ; Grozdev, Ivan ; Weinberg, Jeffrey M ; Nicolopoulos, Jenny ; Wells, Jillian ; Lambert, Jo L.W ; Prinz, Jörg Christoph ; de Souza Sittart, José Alexandre ; Castro-Ayarza, Juan Raul ; van den Reek, Juul M.P.A ; Trcko, Katarina ; Barber, Kirk ; Khobzei, Kuzma ; Fardet, Laurence ; le Cleach, Laurence ; Misery, Laurent ; Lecluse, Lidian ; Skov, Lone ; Frez, Ma. Lorna ; Babic, Lucija Tomic ; Dutil, Maha ; El-Sayed, Mahira Hamdy ; Olszewska, Malgorzata ; Schram, Mandy Elvira ; Llamas-Velasco, Mar ; Gonçalo, Margarida ; Velásquez-Lopera, Margarita M ; de Oliveira, Maria de Fátima Santos Paim ; Kaštelan, Marija ; Rademaker, Marius ; Sikora, Mariusz ; Lebwohl, Mark ; Wiseman, Marni C ; Ferran, Marta ; van Doorn, Martijn ; Danespazhooh, Maryam ; Bylaite-Bucinskiene, Matilda ; Gooderham, Melinda J ; Polic, Melita Vukšic ; Gómez-Flores, Minerva ; Salleras i Redonnet, Montse ; Yawalkar, Nikhil ; Cárdenas Rojas, Paola J ; Gisondi, Paolo ; Grewal, Parbeer ; Sator, Paul ; Luna, Paula Carolina ; Holló, Péter ; Calzavara-Pinton, Piergiacomo ; Ghislain, Pierre-Dominique ; Araujo, Raquel Ruiz ; Romiti, Ricardo ; Ceovic, Romana ; Vender, Ronald ; Lafuente-Urrez, Rosario Fátima ; Gulin, Sandra J ; Handa, Sanjeev ; Kolalapudi, Seetharam A ; Marrón, Servando E ; Azimi, Seyyede Zeinab ; Ayanlowo, Olusola ; Margasin, Susana M ; Hurtová, Tatiana ; Liu, Tong-Yun ; Leonidze, Tsira ; Veldkamp, Wendelien</creator><creatorcontrib>van Huizen, Astrid M ; Gyulai, Rolland ; Warren, Richard B ; Egeberg, Alexander ; Kumar, Alur S ; Oakley, Amanda ; Ramos, Andrea Machado Coelho ; Fougerousse, Anne-Claire ; Horváth, Barbara ; Fábos, Béata ; Castro, Carla ; Ferrándiz, Carlos ; Goujon, Catherine ; Gonzalez, Cesar ; Maldonado-García, César ; Griffiths, Christopher E.M ; Vestergaard, Christian ; Conrad, Curdin ; Jullien, Denis ; Appelen, Diebrecht ; Kim, Dong Hyun ; de Jong, Elke M.G.J ; El Gamal, Emad ; Mahé, Emmanuel ; Sonkoly, Enikö ; Willaert, Fabienne ; Handjani, Farhad ; Vílchez-Márquez, Francisco ; Damiani, Giovanni ; Pellerano, Graciela ; Hunter, Hamish J. A ; Riad, Hassan ; Boonen, Hugo P.J ; Csányi, Ildíko ; Brajac, Ines ; Grozdev, Ivan ; Weinberg, Jeffrey M ; Nicolopoulos, Jenny ; Wells, Jillian ; Lambert, Jo L.W ; Prinz, Jörg Christoph ; de Souza Sittart, José Alexandre ; Castro-Ayarza, Juan Raul ; van den Reek, Juul M.P.A ; Trcko, Katarina ; Barber, Kirk ; Khobzei, Kuzma ; Fardet, Laurence ; le Cleach, Laurence ; Misery, Laurent ; Lecluse, Lidian ; Skov, Lone ; Frez, Ma. Lorna ; Babic, Lucija Tomic ; Dutil, Maha ; El-Sayed, Mahira Hamdy ; Olszewska, Malgorzata ; Schram, Mandy Elvira ; Llamas-Velasco, Mar ; Gonçalo, Margarida ; Velásquez-Lopera, Margarita M ; de Oliveira, Maria de Fátima Santos Paim ; Kaštelan, Marija ; Rademaker, Marius ; Sikora, Mariusz ; Lebwohl, Mark ; Wiseman, Marni C ; Ferran, Marta ; van Doorn, Martijn ; Danespazhooh, Maryam ; Bylaite-Bucinskiene, Matilda ; Gooderham, Melinda J ; Polic, Melita Vukšic ; Gómez-Flores, Minerva ; Salleras i Redonnet, Montse ; Yawalkar, Nikhil ; Cárdenas Rojas, Paola J ; Gisondi, Paolo ; Grewal, Parbeer ; Sator, Paul ; Luna, Paula Carolina ; Holló, Péter ; Calzavara-Pinton, Piergiacomo ; Ghislain, Pierre-Dominique ; Araujo, Raquel Ruiz ; Romiti, Ricardo ; Ceovic, Romana ; Vender, Ronald ; Lafuente-Urrez, Rosario Fátima ; Gulin, Sandra J ; Handa, Sanjeev ; Kolalapudi, Seetharam A ; Marrón, Servando E ; Azimi, Seyyede Zeinab ; Ayanlowo, Olusola ; Margasin, Susana M ; Hurtová, Tatiana ; Liu, Tong-Yun ; Leonidze, Tsira ; Veldkamp, Wendelien ; SPIN MTX Consensus Survey Study Group</creatorcontrib><description>IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.</description><identifier>ISSN: 2168-6068</identifier><identifier>ISSN: 2168-6084</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/jamadermatol.2022.0434</identifier><identifier>PMID: 35353175</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adult ; Child ; Consensus ; Dermatology ; Folic Acid ; Humans ; Medical treatment ; Methotrexate ; Pediatrics ; Psoriasis ; Psoriasis - therapy ; Skin diseases ; Surveys and Questionnaires</subject><ispartof>Archives of dermatology (1960), 2022-05, Vol.158 (5), p.561-572</ispartof><rights>Copyright American Medical Association May 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a481t-ab6a80825e47e5b2cef8a600374a71015f65080b7f48fcb3d3b86aa79a9ff26e3</citedby><cites>FETCH-LOGICAL-a481t-ab6a80825e47e5b2cef8a600374a71015f65080b7f48fcb3d3b86aa79a9ff26e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/jamadermatol.2022.0434$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/jamadermatol.2022.0434$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,230,314,551,777,781,882,3327,27905,27906,76238,76241</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35353175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-475147$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:149228843$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>van Huizen, Astrid M</creatorcontrib><creatorcontrib>Gyulai, Rolland</creatorcontrib><creatorcontrib>Warren, Richard B</creatorcontrib><creatorcontrib>Egeberg, Alexander</creatorcontrib><creatorcontrib>Kumar, Alur S</creatorcontrib><creatorcontrib>Oakley, Amanda</creatorcontrib><creatorcontrib>Ramos, Andrea Machado Coelho</creatorcontrib><creatorcontrib>Fougerousse, Anne-Claire</creatorcontrib><creatorcontrib>Horváth, Barbara</creatorcontrib><creatorcontrib>Fábos, Béata</creatorcontrib><creatorcontrib>Castro, Carla</creatorcontrib><creatorcontrib>Ferrándiz, Carlos</creatorcontrib><creatorcontrib>Goujon, Catherine</creatorcontrib><creatorcontrib>Gonzalez, Cesar</creatorcontrib><creatorcontrib>Maldonado-García, César</creatorcontrib><creatorcontrib>Griffiths, Christopher E.M</creatorcontrib><creatorcontrib>Vestergaard, Christian</creatorcontrib><creatorcontrib>Conrad, Curdin</creatorcontrib><creatorcontrib>Jullien, Denis</creatorcontrib><creatorcontrib>Appelen, Diebrecht</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>de Jong, Elke M.G.J</creatorcontrib><creatorcontrib>El Gamal, Emad</creatorcontrib><creatorcontrib>Mahé, Emmanuel</creatorcontrib><creatorcontrib>Sonkoly, Enikö</creatorcontrib><creatorcontrib>Willaert, Fabienne</creatorcontrib><creatorcontrib>Handjani, Farhad</creatorcontrib><creatorcontrib>Vílchez-Márquez, Francisco</creatorcontrib><creatorcontrib>Damiani, Giovanni</creatorcontrib><creatorcontrib>Pellerano, Graciela</creatorcontrib><creatorcontrib>Hunter, Hamish J. 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Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.</description><subject>Adult</subject><subject>Child</subject><subject>Consensus</subject><subject>Dermatology</subject><subject>Folic Acid</subject><subject>Humans</subject><subject>Medical treatment</subject><subject>Methotrexate</subject><subject>Pediatrics</subject><subject>Psoriasis</subject><subject>Psoriasis - therapy</subject><subject>Skin diseases</subject><subject>Surveys and Questionnaires</subject><issn>2168-6068</issn><issn>2168-6084</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kUtvGyEUhVHVqonc_IEuIqRuOy4wDOBlZPcRKVWjPpfojn3HgzsDDjBq8--LZdfqprDgCr5zdLmHkGvO5pwx_mYHI2wwjpDDMBdMiDmTtXxCLgVXplLMyKfnWpkLcpXSjpVlWOH4c3JRN2Vz3VyS4dZnjB6yCx4Giisc9r2jX_K0eaQ50M8I654ug0_o05Ro8DT3SD9i7kOO-Bsy0lVIzm8LunUjeuo8vS9-6HOiP1zu6X0K0UFy6QV51sGQ8Op0zsi3d2-_Lj9Ud5_e3y5v7iqQhucKWgWGGdGg1Ni0Yo2dAcVYrSVoznjTqab8pdWdNN26rTd1axSAXsCi64TCekaqo2_6hfuptfvoRoiPNoCzp6ufpUIrGymFLvzr__Ir9_3Ghri102Slbrg84K-O-D6GhwlTtrswlRkOyQqltGlqXcY7I-pIrWNIKWJ3tuXMHmK0_8ZoDzHaQ4xFeH2yn9oRN2fZ39AK8PIIFP35VegFq0tzfwDCPaY8</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>van Huizen, Astrid M</creator><creator>Gyulai, Rolland</creator><creator>Warren, Richard B</creator><creator>Egeberg, Alexander</creator><creator>Kumar, Alur S</creator><creator>Oakley, Amanda</creator><creator>Ramos, Andrea Machado Coelho</creator><creator>Fougerousse, Anne-Claire</creator><creator>Horváth, Barbara</creator><creator>Fábos, Béata</creator><creator>Castro, Carla</creator><creator>Ferrándiz, Carlos</creator><creator>Goujon, Catherine</creator><creator>Gonzalez, Cesar</creator><creator>Maldonado-García, César</creator><creator>Griffiths, Christopher E.M</creator><creator>Vestergaard, Christian</creator><creator>Conrad, Curdin</creator><creator>Jullien, Denis</creator><creator>Appelen, Diebrecht</creator><creator>Kim, Dong Hyun</creator><creator>de Jong, Elke M.G.J</creator><creator>El Gamal, Emad</creator><creator>Mahé, Emmanuel</creator><creator>Sonkoly, Enikö</creator><creator>Willaert, Fabienne</creator><creator>Handjani, Farhad</creator><creator>Vílchez-Márquez, Francisco</creator><creator>Damiani, Giovanni</creator><creator>Pellerano, Graciela</creator><creator>Hunter, Hamish J. 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A ; Riad, Hassan ; Boonen, Hugo P.J ; Csányi, Ildíko ; Brajac, Ines ; Grozdev, Ivan ; Weinberg, Jeffrey M ; Nicolopoulos, Jenny ; Wells, Jillian ; Lambert, Jo L.W ; Prinz, Jörg Christoph ; de Souza Sittart, José Alexandre ; Castro-Ayarza, Juan Raul ; van den Reek, Juul M.P.A ; Trcko, Katarina ; Barber, Kirk ; Khobzei, Kuzma ; Fardet, Laurence ; le Cleach, Laurence ; Misery, Laurent ; Lecluse, Lidian ; Skov, Lone ; Frez, Ma. Lorna ; Babic, Lucija Tomic ; Dutil, Maha ; El-Sayed, Mahira Hamdy ; Olszewska, Malgorzata ; Schram, Mandy Elvira ; Llamas-Velasco, Mar ; Gonçalo, Margarida ; Velásquez-Lopera, Margarita M ; de Oliveira, Maria de Fátima Santos Paim ; Kaštelan, Marija ; Rademaker, Marius ; Sikora, Mariusz ; Lebwohl, Mark ; Wiseman, Marni C ; Ferran, Marta ; van Doorn, Martijn ; Danespazhooh, Maryam ; Bylaite-Bucinskiene, Matilda ; Gooderham, Melinda J ; Polic, Melita Vukšic ; Gómez-Flores, Minerva ; Salleras i Redonnet, Montse ; Yawalkar, Nikhil ; Cárdenas Rojas, Paola J ; Gisondi, Paolo ; Grewal, Parbeer ; Sator, Paul ; Luna, Paula Carolina ; Holló, Péter ; Calzavara-Pinton, Piergiacomo ; Ghislain, Pierre-Dominique ; Araujo, Raquel Ruiz ; Romiti, Ricardo ; Ceovic, Romana ; Vender, Ronald ; Lafuente-Urrez, Rosario Fátima ; Gulin, Sandra J ; Handa, Sanjeev ; Kolalapudi, Seetharam A ; Marrón, Servando E ; Azimi, Seyyede Zeinab ; Ayanlowo, Olusola ; Margasin, Susana M ; Hurtová, Tatiana ; Liu, Tong-Yun ; Leonidze, Tsira ; Veldkamp, Wendelien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a481t-ab6a80825e47e5b2cef8a600374a71015f65080b7f48fcb3d3b86aa79a9ff26e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Child</topic><topic>Consensus</topic><topic>Dermatology</topic><topic>Folic Acid</topic><topic>Humans</topic><topic>Medical treatment</topic><topic>Methotrexate</topic><topic>Pediatrics</topic><topic>Psoriasis</topic><topic>Psoriasis - therapy</topic><topic>Skin diseases</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Huizen, Astrid M</creatorcontrib><creatorcontrib>Gyulai, Rolland</creatorcontrib><creatorcontrib>Warren, Richard B</creatorcontrib><creatorcontrib>Egeberg, Alexander</creatorcontrib><creatorcontrib>Kumar, Alur S</creatorcontrib><creatorcontrib>Oakley, Amanda</creatorcontrib><creatorcontrib>Ramos, Andrea Machado Coelho</creatorcontrib><creatorcontrib>Fougerousse, Anne-Claire</creatorcontrib><creatorcontrib>Horváth, Barbara</creatorcontrib><creatorcontrib>Fábos, Béata</creatorcontrib><creatorcontrib>Castro, Carla</creatorcontrib><creatorcontrib>Ferrándiz, Carlos</creatorcontrib><creatorcontrib>Goujon, Catherine</creatorcontrib><creatorcontrib>Gonzalez, Cesar</creatorcontrib><creatorcontrib>Maldonado-García, César</creatorcontrib><creatorcontrib>Griffiths, Christopher E.M</creatorcontrib><creatorcontrib>Vestergaard, Christian</creatorcontrib><creatorcontrib>Conrad, Curdin</creatorcontrib><creatorcontrib>Jullien, Denis</creatorcontrib><creatorcontrib>Appelen, Diebrecht</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>de Jong, Elke M.G.J</creatorcontrib><creatorcontrib>El Gamal, Emad</creatorcontrib><creatorcontrib>Mahé, Emmanuel</creatorcontrib><creatorcontrib>Sonkoly, Enikö</creatorcontrib><creatorcontrib>Willaert, Fabienne</creatorcontrib><creatorcontrib>Handjani, Farhad</creatorcontrib><creatorcontrib>Vílchez-Márquez, Francisco</creatorcontrib><creatorcontrib>Damiani, Giovanni</creatorcontrib><creatorcontrib>Pellerano, Graciela</creatorcontrib><creatorcontrib>Hunter, Hamish J. 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A</au><au>Riad, Hassan</au><au>Boonen, Hugo P.J</au><au>Csányi, Ildíko</au><au>Brajac, Ines</au><au>Grozdev, Ivan</au><au>Weinberg, Jeffrey M</au><au>Nicolopoulos, Jenny</au><au>Wells, Jillian</au><au>Lambert, Jo L.W</au><au>Prinz, Jörg Christoph</au><au>de Souza Sittart, José Alexandre</au><au>Castro-Ayarza, Juan Raul</au><au>van den Reek, Juul M.P.A</au><au>Trcko, Katarina</au><au>Barber, Kirk</au><au>Khobzei, Kuzma</au><au>Fardet, Laurence</au><au>le Cleach, Laurence</au><au>Misery, Laurent</au><au>Lecluse, Lidian</au><au>Skov, Lone</au><au>Frez, Ma. Lorna</au><au>Babic, Lucija Tomic</au><au>Dutil, Maha</au><au>El-Sayed, Mahira Hamdy</au><au>Olszewska, Malgorzata</au><au>Schram, Mandy Elvira</au><au>Llamas-Velasco, Mar</au><au>Gonçalo, Margarida</au><au>Velásquez-Lopera, Margarita M</au><au>de Oliveira, Maria de Fátima Santos Paim</au><au>Kaštelan, Marija</au><au>Rademaker, Marius</au><au>Sikora, Mariusz</au><au>Lebwohl, Mark</au><au>Wiseman, Marni C</au><au>Ferran, Marta</au><au>van Doorn, Martijn</au><au>Danespazhooh, Maryam</au><au>Bylaite-Bucinskiene, Matilda</au><au>Gooderham, Melinda J</au><au>Polic, Melita Vukšic</au><au>Gómez-Flores, Minerva</au><au>Salleras i Redonnet, Montse</au><au>Yawalkar, Nikhil</au><au>Cárdenas Rojas, Paola J</au><au>Gisondi, Paolo</au><au>Grewal, Parbeer</au><au>Sator, Paul</au><au>Luna, Paula Carolina</au><au>Holló, Péter</au><au>Calzavara-Pinton, Piergiacomo</au><au>Ghislain, Pierre-Dominique</au><au>Araujo, Raquel Ruiz</au><au>Romiti, Ricardo</au><au>Ceovic, Romana</au><au>Vender, Ronald</au><au>Lafuente-Urrez, Rosario Fátima</au><au>Gulin, Sandra J</au><au>Handa, Sanjeev</au><au>Kolalapudi, Seetharam A</au><au>Marrón, Servando E</au><au>Azimi, Seyyede Zeinab</au><au>Ayanlowo, Olusola</au><au>Margasin, Susana M</au><au>Hurtová, Tatiana</au><au>Liu, Tong-Yun</au><au>Leonidze, Tsira</au><au>Veldkamp, Wendelien</au><aucorp>SPIN MTX Consensus Survey Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>JAMA Dermatol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>158</volume><issue>5</issue><spage>561</spage><epage>572</epage><pages>561-572</pages><issn>2168-6068</issn><issn>2168-6084</issn><eissn>2168-6084</eissn><abstract>IMPORTANCE: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. OBJECTIVE: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. DESIGN, SETTING, AND PARTICIPANTS: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). MAIN OUTCOMES AND MEASURES: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. RESULTS: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. CONCLUSIONS AND RELEVANCE: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>35353175</pmid><doi>10.1001/jamadermatol.2022.0434</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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2168-6084
2168-6084
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source MEDLINE; American Medical Association Journals; SWEPUB Freely available online
subjects Adult
Child
Consensus
Dermatology
Folic Acid
Humans
Medical treatment
Methotrexate
Pediatrics
Psoriasis
Psoriasis - therapy
Skin diseases
Surveys and Questionnaires
title International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis
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