Mapping anorexia nervosa genes to clinical phenotypes

Anorexia nervosa (AN) is a psychiatric disorder with complex etiology, with a significant portion of disease risk imparted by genetics. Traditional genome-wide association studies (GWAS) produce principal evidence for the association of genetic variants with disease. Transcriptomic imputation (TI) a...

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Veröffentlicht in:	Psychological medicine 2023-04, Vol.53 (6), p.2619-2633
Hauptverfasser:	Johnson, Jessica S., Cote, Alanna C., Dobbyn, Amanda, Sloofman, Laura G., Xu, Jiayi, Cotter, Liam, Charney, Alexander W., Birgegård, Andreas, Jordan, Jennifer, Kennedy, Martin, Landén, Mikaél, Maguire, Sarah L., Martin, Nicholas G., Mortensen, Preben Bo, Thornton, Laura M., Bulik, Cynthia M., Huckins, Laura M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anorexia Anorexia nervosa Anorexia Nervosa - genetics Associations Biobanks bipolar disorders Body mass index Celiac disease Cholesterol circadian genes Codes Eating disorders Ecosystems EHR Electronic health records Electronic medical records Etiology Gene expression Gene mapping Genealogy Genes Genetic diversity Genetic Predisposition to Disease - genetics genome-wide association Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotype & phenotype Humans Major histocompatibility complex Mapping Mental disorders Metabolism Moderation Neurosciences Neurovetenskaper Original Original Article Ovaries Pain Phenotype Phenotypes pheWAS Polymorphism, Single Nucleotide PrediXcan Prostate Psychiatry Psychology risk Substance abuse Substance use Transcriptome transcriptomic imputation Transcriptomics Translation Uterus Vagina Variants Vital signs
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