Gut microbiota and diabetic kidney diseases: Pathogenesis and therapeutic perspectives
Diabetic kidney disease (DKD) is one of the major chronic complications of diabetes mellitus (DM), as well as a main cause of end-stage renal disease. Over the last few years, substantial research studies have revealed a contributory role of gut microbiota in the process of DM and DKD. Metabolites o...
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| Veröffentlicht in: | WORLD JOURNAL OF DIABETES 2022-04, Vol.13 (4), p.308-318 |
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| container_title | WORLD JOURNAL OF DIABETES |
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| creator | Lin, Jia-Ran Wang, Zi-Ting Sun, Jiao-Jiao Yang, Ying-Ying Li, Xue-Xin Wang, Xin-Ru Shi, Yue Zhu, Yuan-Yuan Wang, Rui-Ting Wang, Mi-Na Xie, Fei-Yu Wei, Peng Liao, Ze-Huan |
| description | Diabetic kidney disease (DKD) is one of the major chronic complications of diabetes mellitus (DM), as well as a main cause of end-stage renal disease. Over the last few years, substantial research studies have revealed a contributory role of gut microbiota in the process of DM and DKD. Metabolites of gut microbiota like lipopolysaccharide, short-chain fatty acids, and trimethylamine N-oxide are key mediators of microbial-host crosstalk. However, the underlying mechanisms of how gut microbiota influences the onset and progression of DKD are relatively unknown. Besides, strategies to remodel the composition of gut microbiota or to reduce the metabolites of microbiota have been found recently, representing a new potential remedial target for DKD. In this mini-review, we will address the possible contribution of the gut microbiota in the pathogenesis of DKD and its role as a therapeutic target. |
| doi_str_mv | 10.4239/wjd.v13.i4.308 |
| format | Article |
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Over the last few years, substantial research studies have revealed a contributory role of gut microbiota in the process of DM and DKD. Metabolites of gut microbiota like lipopolysaccharide, short-chain fatty acids, and trimethylamine N-oxide are key mediators of microbial-host crosstalk. However, the underlying mechanisms of how gut microbiota influences the onset and progression of DKD are relatively unknown. Besides, strategies to remodel the composition of gut microbiota or to reduce the metabolites of microbiota have been found recently, representing a new potential remedial target for DKD. In this mini-review, we will address the possible contribution of the gut microbiota in the pathogenesis of DKD and its role as a therapeutic target.</description><identifier>ISSN: 1948-9358</identifier><identifier>EISSN: 1948-9358</identifier><identifier>DOI: 10.4239/wjd.v13.i4.308</identifier><identifier>PMID: 35582668</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Minireviews</subject><ispartof>WORLD JOURNAL OF DIABETES, 2022-04, Vol.13 (4), p.308-318</ispartof><rights>The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.</rights><rights>The Author(s) 2022. Published by Baishideng Publishing Group Inc. 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| source | Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SWEPUB Freely available online |
| subjects | Minireviews |
| title | Gut microbiota and diabetic kidney diseases: Pathogenesis and therapeutic perspectives |
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