Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit

Nonresolving inflammation underlies a range of chronic inflammatory diseases, and therapeutic acceleration of resolution of inflammation may improve outcomes. Neural reflexes regulate the intensity of inflammation (for example, through signals in the vagus nerve), but whether activation of the vagus...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-05, Vol.119 (22), p.1-11
Hauptverfasser:	Caravaca, April S., Gallina, Alessandro L., Tarnawski, Laura, Shavva, Vladimir S., Colas, Romain A., Dalli, Jesmond, Malin, Stephen G., Hult, Henrik, Arnardottir, Hildur, Olofsson, Peder S.
Format:	Artikel
Sprache:	eng
Schlagworte:	a7nAChR gene Alox15 gene Alox15 protein alpha7 Nicotinic Acetylcholine Receptor alpha7 Nicotinic Acetylcholine Receptor - genetics animal animal cell animal experiment animal model animal tissue Animals Arachidonate 12-Lipoxygenase Arachidonate 12-Lipoxygenase - genetics Arachidonate 12-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase Arachidonate 15-Lipoxygenase - genetics Arachidonate 15-Lipoxygenase - metabolism autacoid autonomic reflex Biological Sciences Biosynthesis bungarotoxin receptor cervonic acid Cholinergics controlled study disease duration Disease Models, Animal docosapentaenoic acid efferocytosis ex vivo study Exudates Exudation gene genetics In vivo methods and tests in vivo study Inflammation Inflammation - therapy Inflammation Mediators Inflammation Mediators - metabolism Inflammatory diseases Leukocytes (neutrophilic) lipid mediators lipidomics Lipids male Mice Mice, Mutant Strains mouse Nerves nervous system inflammation neuroinflammation nonhuman Peritoneum peritoneum exudate Peritonitis physiology Reflexes Stimulation surgical technique Vagus Nerve Vagus Nerve - physiology Vagus Nerve Stimulation zymosan
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