Highly sensitive detection of EGFR L858R mutation at the mRNA level

The missense mutation EGFR L858R implies increased sensitivity to EGFR tyrosine kinase inhibitor (TKIs) therapy, despite a significant non-response rate. Currently, detection of EGFR L858R mutation is mostly DNA based, therefore, the allele-specific expression level of the mutated gene and its clini...

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Veröffentlicht in:	Analytical biochemistry 2022-10, Vol.654, p.114799-114799, Article 114799
Hauptverfasser:	Pham, Mai, Pham, Quynh, Nguyen, Ung, Nguyen, Lanh, Nguyen, Hoa, Vu, Thang, Nguyen, Ba, Stenman, Jakob, Tho, Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Allele-specific gene expression biomarkers Cancer biomarker Circulating mRNA detection limit DNA EGFR L858R mutation gene expression genes Liquid biopsy missense mutation neoplasms reverse transcription RNA-based mutation analysis therapeutics tyrosine
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