Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure
Preeclampsia causes significant maternal and perinatal morbidity. Genetic factors seem to affect the onset of the disease. We aimed to investigate whether the polygenic risk score for blood pressure (BP; BP-PRS) is associated with preeclampsia, its subtypes, and BP values during pregnancy. The analy...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-09, Vol.79 (9), p.2008-2015 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Kivioja, Anna Toivonen, Elli Tyrmi, Jaakko Ruotsalainen, Sanni Ripatti, Samuli Huhtala, Heini Jääskeläinen, Tiina Heinonen, Seppo Kajantie, Eero Kere, Juha Kivinen, Katja Pouta, Anneli Saarela, Tanja Laivuori, Hannele |
| description | Preeclampsia causes significant maternal and perinatal morbidity. Genetic factors seem to affect the onset of the disease. We aimed to investigate whether the polygenic risk score for blood pressure (BP; BP-PRS) is associated with preeclampsia, its subtypes, and BP values during pregnancy.
The analyses were performed in the FINNPEC study (Finnish Genetics of Pre-Eclampsia Consortium) cohort of 1514 preeclamptic and 983 control women. In a case-control setting, the data were divided into percentiles to compare women with high BP-PRS (HBP-PRS; >95th percentile) or low BP-PRS (≤5th percentile) to others. Furthermore, to evaluate the effect of BP-PRS on BP, we studied 3 cohorts: women with preeclampsia, hypertensive controls, and normotensive controls.
BP values were higher in women with HBP-PRS throughout the pregnancy. Preeclampsia was more common in women with HBP-PRS compared with others (71.8% and 60.1%, respectively;
=0.009), and women with low BP-PRS presented with preeclampsia less frequently than others (44.8% and 61.5%, respectively; |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.122.18996 |
| format | Article |
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The analyses were performed in the FINNPEC study (Finnish Genetics of Pre-Eclampsia Consortium) cohort of 1514 preeclamptic and 983 control women. In a case-control setting, the data were divided into percentiles to compare women with high BP-PRS (HBP-PRS; >95th percentile) or low BP-PRS (≤5th percentile) to others. Furthermore, to evaluate the effect of BP-PRS on BP, we studied 3 cohorts: women with preeclampsia, hypertensive controls, and normotensive controls.
BP values were higher in women with HBP-PRS throughout the pregnancy. Preeclampsia was more common in women with HBP-PRS compared with others (71.8% and 60.1%, respectively;
=0.009), and women with low BP-PRS presented with preeclampsia less frequently than others (44.8% and 61.5%, respectively;
<0.001). HBP-PRS was associated with an increased risk for preeclampsia (odds ratio, 1.7 [95% CI, 1.1-2.5]). Furthermore, women with HBP-PRS presented with recurrent preeclampsia and preeclampsia with severe features more often.
Our results suggest that HBP-PRS is associated with an increased risk of preeclampsia, recurrent preeclampsia, and preeclampsia with severe features. Furthermore, women with HBP-PRS present higher BP values during pregnancy. The results strengthen the evidence pointing toward the role of genetic variants associated with BP regulation in the etiology of preeclampsia, especially its more severe forms.</description><identifier>ISSN: 0194-911X</identifier><identifier>ISSN: 1524-4563</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.122.18996</identifier><identifier>PMID: 35862124</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Blood Pressure - genetics ; Cohort Studies ; Female ; Genetic Predisposition to Disease ; Humans ; Hypertension - complications ; Original ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - epidemiology ; Pre-Eclampsia - genetics ; Pregnancy</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2022-09, Vol.79 (9), p.2008-2015</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>2022 The Authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5063-fc83f8aba427fcbc2da07c70d8dd3f0ee8fc99683fcc16a3fad77bedeb2a002b3</citedby><cites>FETCH-LOGICAL-c5063-fc83f8aba427fcbc2da07c70d8dd3f0ee8fc99683fcc16a3fad77bedeb2a002b3</cites><orcidid>0000-0003-3212-7826 ; 0000-0002-4757-6563 ; 0000-0003-1372-430X ; 0000-0001-7081-8391 ; 0000-0002-1135-7625 ; 0000-0002-1202-0936 ; 0000-0002-3958-4176 ; 0000-0003-3321-6839 ; 0000-0001-5637-3445 ; 0000-0002-0504-1202</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35862124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:150439537$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kivioja, Anna</creatorcontrib><creatorcontrib>Toivonen, Elli</creatorcontrib><creatorcontrib>Tyrmi, Jaakko</creatorcontrib><creatorcontrib>Ruotsalainen, Sanni</creatorcontrib><creatorcontrib>Ripatti, Samuli</creatorcontrib><creatorcontrib>Huhtala, Heini</creatorcontrib><creatorcontrib>Jääskeläinen, Tiina</creatorcontrib><creatorcontrib>Heinonen, Seppo</creatorcontrib><creatorcontrib>Kajantie, Eero</creatorcontrib><creatorcontrib>Kere, Juha</creatorcontrib><creatorcontrib>Kivinen, Katja</creatorcontrib><creatorcontrib>Pouta, Anneli</creatorcontrib><creatorcontrib>Saarela, Tanja</creatorcontrib><creatorcontrib>Laivuori, Hannele</creatorcontrib><title>Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Preeclampsia causes significant maternal and perinatal morbidity. Genetic factors seem to affect the onset of the disease. We aimed to investigate whether the polygenic risk score for blood pressure (BP; BP-PRS) is associated with preeclampsia, its subtypes, and BP values during pregnancy.
The analyses were performed in the FINNPEC study (Finnish Genetics of Pre-Eclampsia Consortium) cohort of 1514 preeclamptic and 983 control women. In a case-control setting, the data were divided into percentiles to compare women with high BP-PRS (HBP-PRS; >95th percentile) or low BP-PRS (≤5th percentile) to others. Furthermore, to evaluate the effect of BP-PRS on BP, we studied 3 cohorts: women with preeclampsia, hypertensive controls, and normotensive controls.
BP values were higher in women with HBP-PRS throughout the pregnancy. Preeclampsia was more common in women with HBP-PRS compared with others (71.8% and 60.1%, respectively;
=0.009), and women with low BP-PRS presented with preeclampsia less frequently than others (44.8% and 61.5%, respectively;
<0.001). HBP-PRS was associated with an increased risk for preeclampsia (odds ratio, 1.7 [95% CI, 1.1-2.5]). Furthermore, women with HBP-PRS presented with recurrent preeclampsia and preeclampsia with severe features more often.
Our results suggest that HBP-PRS is associated with an increased risk of preeclampsia, recurrent preeclampsia, and preeclampsia with severe features. Furthermore, women with HBP-PRS present higher BP values during pregnancy. The results strengthen the evidence pointing toward the role of genetic variants associated with BP regulation in the etiology of preeclampsia, especially its more severe forms.</description><subject>Blood Pressure - genetics</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Original</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Pre-Eclampsia - genetics</subject><subject>Pregnancy</subject><issn>0194-911X</issn><issn>1524-4563</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNpdkV1v0zAYhS0EYmXwF1C44ybFX4njG6QylbXStE1jCLgyjv2GmrpxZyer-Pe4tEwMS_58n3Ns6yD0huApITV5t_h2Pb-5nV9-Wl5dzhazKaF0Shop6ydoQirKS17V7CmaYCJ5KQn5eoJepPQTY8I5F8_RCauamhLKJ-j7sjcRdAJb3Li0LkJXXEcA4_Vmm5wuXF98CRvIoxtWhS7OoYfBmT1kXdqG5AYX-mIIxdzDvR6yzwcfgt0DKY0RXqJnnfYJXh3nU_T54_z2bFFeXJ0vz2YXpalwzcrONKxrdKs5FZ1pDbUaCyOwbaxlHQZoOpM_mCFjSK1Zp60QLVhoqcaYtuwUlQfftIPt2KptdBsdf6mgnToerfMKFK-IlE3m3x_4XNmANdAPUftHsseV3q3Uj3CvJBOYViwbvD0axHA3QhrUxiUD3usewpgUrSUVlRC0zqg8oCaGlCJ0D9cQrPaJqv8SVTlR9SfRrH397zsflH8jzAA_ALvgB4hp7ccdRLUC7YeVwrlxWjclxZRimXdl7oSx31gasnY</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Kivioja, Anna</creator><creator>Toivonen, Elli</creator><creator>Tyrmi, Jaakko</creator><creator>Ruotsalainen, Sanni</creator><creator>Ripatti, Samuli</creator><creator>Huhtala, Heini</creator><creator>Jääskeläinen, Tiina</creator><creator>Heinonen, Seppo</creator><creator>Kajantie, Eero</creator><creator>Kere, Juha</creator><creator>Kivinen, Katja</creator><creator>Pouta, Anneli</creator><creator>Saarela, Tanja</creator><creator>Laivuori, Hannele</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-3212-7826</orcidid><orcidid>https://orcid.org/0000-0002-4757-6563</orcidid><orcidid>https://orcid.org/0000-0003-1372-430X</orcidid><orcidid>https://orcid.org/0000-0001-7081-8391</orcidid><orcidid>https://orcid.org/0000-0002-1135-7625</orcidid><orcidid>https://orcid.org/0000-0002-1202-0936</orcidid><orcidid>https://orcid.org/0000-0002-3958-4176</orcidid><orcidid>https://orcid.org/0000-0003-3321-6839</orcidid><orcidid>https://orcid.org/0000-0001-5637-3445</orcidid><orcidid>https://orcid.org/0000-0002-0504-1202</orcidid></search><sort><creationdate>20220901</creationdate><title>Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure</title><author>Kivioja, Anna ; 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Genetic factors seem to affect the onset of the disease. We aimed to investigate whether the polygenic risk score for blood pressure (BP; BP-PRS) is associated with preeclampsia, its subtypes, and BP values during pregnancy.
The analyses were performed in the FINNPEC study (Finnish Genetics of Pre-Eclampsia Consortium) cohort of 1514 preeclamptic and 983 control women. In a case-control setting, the data were divided into percentiles to compare women with high BP-PRS (HBP-PRS; >95th percentile) or low BP-PRS (≤5th percentile) to others. Furthermore, to evaluate the effect of BP-PRS on BP, we studied 3 cohorts: women with preeclampsia, hypertensive controls, and normotensive controls.
BP values were higher in women with HBP-PRS throughout the pregnancy. Preeclampsia was more common in women with HBP-PRS compared with others (71.8% and 60.1%, respectively;
=0.009), and women with low BP-PRS presented with preeclampsia less frequently than others (44.8% and 61.5%, respectively;
<0.001). HBP-PRS was associated with an increased risk for preeclampsia (odds ratio, 1.7 [95% CI, 1.1-2.5]). Furthermore, women with HBP-PRS presented with recurrent preeclampsia and preeclampsia with severe features more often.
Our results suggest that HBP-PRS is associated with an increased risk of preeclampsia, recurrent preeclampsia, and preeclampsia with severe features. Furthermore, women with HBP-PRS present higher BP values during pregnancy. The results strengthen the evidence pointing toward the role of genetic variants associated with BP regulation in the etiology of preeclampsia, especially its more severe forms.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>35862124</pmid><doi>10.1161/HYPERTENSIONAHA.122.18996</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3212-7826</orcidid><orcidid>https://orcid.org/0000-0002-4757-6563</orcidid><orcidid>https://orcid.org/0000-0003-1372-430X</orcidid><orcidid>https://orcid.org/0000-0001-7081-8391</orcidid><orcidid>https://orcid.org/0000-0002-1135-7625</orcidid><orcidid>https://orcid.org/0000-0002-1202-0936</orcidid><orcidid>https://orcid.org/0000-0002-3958-4176</orcidid><orcidid>https://orcid.org/0000-0003-3321-6839</orcidid><orcidid>https://orcid.org/0000-0001-5637-3445</orcidid><orcidid>https://orcid.org/0000-0002-0504-1202</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 2022-09, Vol.79 (9), p.2008-2015 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online |
| subjects | Blood Pressure - genetics Cohort Studies Female Genetic Predisposition to Disease Humans Hypertension - complications Original Pre-Eclampsia - diagnosis Pre-Eclampsia - epidemiology Pre-Eclampsia - genetics Pregnancy |
| title | Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure |
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