Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct murine B cell population known as "age-associated B cells" (ABCs). T-bet-deficient mice have reduced ABCs and impaired humoral immunity. We describe a patient with inherited T-bet deficiency and...

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Veröffentlicht in:	Science immunology 2022-07, Vol.7 (73), p.eabq3277
Hauptverfasser:	Yang, Rui, Avery, Danielle T, Jackson, Katherine J L, Ogishi, Masato, Benhsaien, Ibtihal, Du, Likun, Ye, Xiaofei, Han, Jing, Rosain, Jérémie, Peel, Jessica N, Alyanakian, Marie-Alexandra, Neven, Bénédicte, Winter, Sarah, Puel, Anne, Boisson, Bertrand, Payne, Kathryn J, Wong, Melanie, Russell, Amanda J, Mizoguchi, Yoko, Okada, Satoshi, Uzel, Gulbu, Goodnow, Christopher C, Latour, Sylvain, El Bakkouri, Jalila, Bousfiha, Aziz, Preece, Kahn, Gray, Paul E, Keller, Baerbel, Warnatz, Klaus, Boisson-Dupuis, Stéphanie, Abel, Laurent, Pan-Hammarström, Qiang, Bustamante, Jacinta, Ma, Cindy S, Casanova, Jean-Laurent, Tangye, Stuart G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals B-Lymphocytes CD11c Antigen - metabolism Gene Expression Regulation Humans Immunoglobulin G Life Sciences Lipoproteins - metabolism Lymphocyte Activation Mice Plasma Cells
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