Oral active matrix metalloproteinase‐8 immunotest may be less accurate in haemato‐oncologic patients
Objectives This study examines the associations of active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care immunotest (Periosafe) outcomes with oral health of patients with haemato‐oncologic diseases. Methods Adult patients diagnosed with haematological diseases aimed to be treated with haematopoie...
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| Veröffentlicht in: | Oral diseases 2024-03, Vol.30 (2), p.624-630 |
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| creator | Mauramo, Matti Uutela, Pauliina Sorsa, Timo Tervahartiala, Taina Bornstein, Michael M. Waltimo, Tuomas |
| description | Objectives
This study examines the associations of active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care immunotest (Periosafe) outcomes with oral health of patients with haemato‐oncologic diseases.
Methods
Adult patients diagnosed with haematological diseases aimed to be treated with haematopoietic stem cell transplantation (HSCT) between 2018 and 2019 were included in the study. Clinical and radiological dental examination were taken immediately prior to transplantation. The presence of oral foci of infections, caries or periodontitis was examined and compared with the outcomes of aMMP‐8 immunotest.
Results
Acute oral infection foci were present in 11.9%, chronic in 44.1% and periodontitis in 42.0% of the 143 subjects. aMMP‐8 immunotest was positive in 13.3% of all the 143 subjects. Among subjects with periodontitis (n = 60), the aMMP‐8 immunotest was also positive in 13.3% of these subjects. However, the subjects with positive aMMP‐8 immunotest (n = 19) had more often acute or chronic infection foci and more than one of the examined dental treatment needs compared with subjects with negative immunotest (all p |
| doi_str_mv | 10.1111/odi.14335 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_451721</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2698632193</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4365-923d969d7335934fadba3418f418ab74c5deec7098f955cf48d05d4a0f35c8fa3</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS1ERcuFBS-AIrGBRVr_JvESlUIrVbobkNhZjjOhLk58sZO2d8cj8Iw8CdPmtpWQasnyePSdI3sOIW8YPWS4jmLnD5kUQj0jB6yirKQNV8-xFkqWiovv--RlzpeUsloL_oLsC6W5wtsBuVgnGwrrJn8FxWCn5G-KASYbQtykOIEfbYa_v_80hR-GecROnpDbFi0UAXJGqZuTnaDwY3FhAS0i4nF0McQf3hUbO3kYp_yK7PU2ZHi9O1fk2-eTr8en5fn6y9nxx_PSSVGpUnPR6Up3Nf5GC9nbrrVCsqbHbdtaOtUBuJrqptdKuV42HVWdtLQXyjW9FStSLr75GjZzazbJDzZtTbTe7Fo_sQIjFas5Q14_yeMEukfRvZApKiXn6lb7ftEi-GvGyZjBZwch2BHinA2vdFMJzrRA9N1_6GWc04iTMBwz0XVdI7oiHxbKpZhzgv7hOYya26gNRm3uokb27c5xbgfoHsj7bBE4WoBrH2D7tJNZfzpbLP8Bw_O25A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2932977786</pqid></control><display><type>article</type><title>Oral active matrix metalloproteinase‐8 immunotest may be less accurate in haemato‐oncologic patients</title><source>SWEPUB Freely available online</source><source>Access via Wiley Online Library</source><creator>Mauramo, Matti ; Uutela, Pauliina ; Sorsa, Timo ; Tervahartiala, Taina ; Bornstein, Michael M. ; Waltimo, Tuomas</creator><creatorcontrib>Mauramo, Matti ; Uutela, Pauliina ; Sorsa, Timo ; Tervahartiala, Taina ; Bornstein, Michael M. ; Waltimo, Tuomas</creatorcontrib><description>Objectives
This study examines the associations of active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care immunotest (Periosafe) outcomes with oral health of patients with haemato‐oncologic diseases.
Methods
Adult patients diagnosed with haematological diseases aimed to be treated with haematopoietic stem cell transplantation (HSCT) between 2018 and 2019 were included in the study. Clinical and radiological dental examination were taken immediately prior to transplantation. The presence of oral foci of infections, caries or periodontitis was examined and compared with the outcomes of aMMP‐8 immunotest.
Results
Acute oral infection foci were present in 11.9%, chronic in 44.1% and periodontitis in 42.0% of the 143 subjects. aMMP‐8 immunotest was positive in 13.3% of all the 143 subjects. Among subjects with periodontitis (n = 60), the aMMP‐8 immunotest was also positive in 13.3% of these subjects. However, the subjects with positive aMMP‐8 immunotest (n = 19) had more often acute or chronic infection foci and more than one of the examined dental treatment needs compared with subjects with negative immunotest (all p < 0.05). There were no differences in age, sex, hyposalivation, DMFT‐index values nor with plasma levels of leukocytes, neutrophils or C‐reactive protein between subjects with positive or negative aMMP‐8 immunotest.
Conclusions
aMMP‐8 immunotest accuracy might be reduced, in relation to periodontitis, in haemato‐oncologic patients.</description><identifier>ISSN: 1354-523X</identifier><identifier>ISSN: 1601-0825</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.14335</identifier><identifier>PMID: 35925017</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Chronic infection ; Clinical outcomes ; Dental caries ; Gum disease ; Hematological diseases ; Hematology ; hematopoietic stem cell transplantation ; Hematopoietic stem cells ; leukaemia ; Leukocytes (neutrophilic) ; Matrix metalloproteinase ; Medicin och hälsovetenskap ; Metalloproteinase ; MMP‐8 ; Oral cancer ; Oral infection ; Patients ; Periodontics ; Periodontitis ; Plasma levels ; Stem cell transplantation</subject><ispartof>Oral diseases, 2024-03, Vol.30 (2), p.624-630</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC.</rights><rights>2022 The Authors. Oral Diseases published by Wiley Periodicals LLC.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4365-923d969d7335934fadba3418f418ab74c5deec7098f955cf48d05d4a0f35c8fa3</cites><orcidid>0000-0002-0107-4939</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.14335$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.14335$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35925017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:150442251$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Mauramo, Matti</creatorcontrib><creatorcontrib>Uutela, Pauliina</creatorcontrib><creatorcontrib>Sorsa, Timo</creatorcontrib><creatorcontrib>Tervahartiala, Taina</creatorcontrib><creatorcontrib>Bornstein, Michael M.</creatorcontrib><creatorcontrib>Waltimo, Tuomas</creatorcontrib><title>Oral active matrix metalloproteinase‐8 immunotest may be less accurate in haemato‐oncologic patients</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objectives
This study examines the associations of active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care immunotest (Periosafe) outcomes with oral health of patients with haemato‐oncologic diseases.
Methods
Adult patients diagnosed with haematological diseases aimed to be treated with haematopoietic stem cell transplantation (HSCT) between 2018 and 2019 were included in the study. Clinical and radiological dental examination were taken immediately prior to transplantation. The presence of oral foci of infections, caries or periodontitis was examined and compared with the outcomes of aMMP‐8 immunotest.
Results
Acute oral infection foci were present in 11.9%, chronic in 44.1% and periodontitis in 42.0% of the 143 subjects. aMMP‐8 immunotest was positive in 13.3% of all the 143 subjects. Among subjects with periodontitis (n = 60), the aMMP‐8 immunotest was also positive in 13.3% of these subjects. However, the subjects with positive aMMP‐8 immunotest (n = 19) had more often acute or chronic infection foci and more than one of the examined dental treatment needs compared with subjects with negative immunotest (all p < 0.05). There were no differences in age, sex, hyposalivation, DMFT‐index values nor with plasma levels of leukocytes, neutrophils or C‐reactive protein between subjects with positive or negative aMMP‐8 immunotest.
Conclusions
aMMP‐8 immunotest accuracy might be reduced, in relation to periodontitis, in haemato‐oncologic patients.</description><subject>Chronic infection</subject><subject>Clinical outcomes</subject><subject>Dental caries</subject><subject>Gum disease</subject><subject>Hematological diseases</subject><subject>Hematology</subject><subject>hematopoietic stem cell transplantation</subject><subject>Hematopoietic stem cells</subject><subject>leukaemia</subject><subject>Leukocytes (neutrophilic)</subject><subject>Matrix metalloproteinase</subject><subject>Medicin och hälsovetenskap</subject><subject>Metalloproteinase</subject><subject>MMP‐8</subject><subject>Oral cancer</subject><subject>Oral infection</subject><subject>Patients</subject><subject>Periodontics</subject><subject>Periodontitis</subject><subject>Plasma levels</subject><subject>Stem cell transplantation</subject><issn>1354-523X</issn><issn>1601-0825</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>D8T</sourceid><recordid>eNp1kc1u1TAQhS1ERcuFBS-AIrGBRVr_JvESlUIrVbobkNhZjjOhLk58sZO2d8cj8Iw8CdPmtpWQasnyePSdI3sOIW8YPWS4jmLnD5kUQj0jB6yirKQNV8-xFkqWiovv--RlzpeUsloL_oLsC6W5wtsBuVgnGwrrJn8FxWCn5G-KASYbQtykOIEfbYa_v_80hR-GecROnpDbFi0UAXJGqZuTnaDwY3FhAS0i4nF0McQf3hUbO3kYp_yK7PU2ZHi9O1fk2-eTr8en5fn6y9nxx_PSSVGpUnPR6Up3Nf5GC9nbrrVCsqbHbdtaOtUBuJrqptdKuV42HVWdtLQXyjW9FStSLr75GjZzazbJDzZtTbTe7Fo_sQIjFas5Q14_yeMEukfRvZApKiXn6lb7ftEi-GvGyZjBZwch2BHinA2vdFMJzrRA9N1_6GWc04iTMBwz0XVdI7oiHxbKpZhzgv7hOYya26gNRm3uokb27c5xbgfoHsj7bBE4WoBrH2D7tJNZfzpbLP8Bw_O25A</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Mauramo, Matti</creator><creator>Uutela, Pauliina</creator><creator>Sorsa, Timo</creator><creator>Tervahartiala, Taina</creator><creator>Bornstein, Michael M.</creator><creator>Waltimo, Tuomas</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-0107-4939</orcidid></search><sort><creationdate>202403</creationdate><title>Oral active matrix metalloproteinase‐8 immunotest may be less accurate in haemato‐oncologic patients</title><author>Mauramo, Matti ; Uutela, Pauliina ; Sorsa, Timo ; Tervahartiala, Taina ; Bornstein, Michael M. ; Waltimo, Tuomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4365-923d969d7335934fadba3418f418ab74c5deec7098f955cf48d05d4a0f35c8fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Chronic infection</topic><topic>Clinical outcomes</topic><topic>Dental caries</topic><topic>Gum disease</topic><topic>Hematological diseases</topic><topic>Hematology</topic><topic>hematopoietic stem cell transplantation</topic><topic>Hematopoietic stem cells</topic><topic>leukaemia</topic><topic>Leukocytes (neutrophilic)</topic><topic>Matrix metalloproteinase</topic><topic>Medicin och hälsovetenskap</topic><topic>Metalloproteinase</topic><topic>MMP‐8</topic><topic>Oral cancer</topic><topic>Oral infection</topic><topic>Patients</topic><topic>Periodontics</topic><topic>Periodontitis</topic><topic>Plasma levels</topic><topic>Stem cell transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mauramo, Matti</creatorcontrib><creatorcontrib>Uutela, Pauliina</creatorcontrib><creatorcontrib>Sorsa, Timo</creatorcontrib><creatorcontrib>Tervahartiala, Taina</creatorcontrib><creatorcontrib>Bornstein, Michael M.</creatorcontrib><creatorcontrib>Waltimo, Tuomas</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mauramo, Matti</au><au>Uutela, Pauliina</au><au>Sorsa, Timo</au><au>Tervahartiala, Taina</au><au>Bornstein, Michael M.</au><au>Waltimo, Tuomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral active matrix metalloproteinase‐8 immunotest may be less accurate in haemato‐oncologic patients</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2024-03</date><risdate>2024</risdate><volume>30</volume><issue>2</issue><spage>624</spage><epage>630</epage><pages>624-630</pages><issn>1354-523X</issn><issn>1601-0825</issn><eissn>1601-0825</eissn><abstract>Objectives
This study examines the associations of active matrix metalloproteinase‐8 (aMMP‐8) point‐of‐care immunotest (Periosafe) outcomes with oral health of patients with haemato‐oncologic diseases.
Methods
Adult patients diagnosed with haematological diseases aimed to be treated with haematopoietic stem cell transplantation (HSCT) between 2018 and 2019 were included in the study. Clinical and radiological dental examination were taken immediately prior to transplantation. The presence of oral foci of infections, caries or periodontitis was examined and compared with the outcomes of aMMP‐8 immunotest.
Results
Acute oral infection foci were present in 11.9%, chronic in 44.1% and periodontitis in 42.0% of the 143 subjects. aMMP‐8 immunotest was positive in 13.3% of all the 143 subjects. Among subjects with periodontitis (n = 60), the aMMP‐8 immunotest was also positive in 13.3% of these subjects. However, the subjects with positive aMMP‐8 immunotest (n = 19) had more often acute or chronic infection foci and more than one of the examined dental treatment needs compared with subjects with negative immunotest (all p < 0.05). There were no differences in age, sex, hyposalivation, DMFT‐index values nor with plasma levels of leukocytes, neutrophils or C‐reactive protein between subjects with positive or negative aMMP‐8 immunotest.
Conclusions
aMMP‐8 immunotest accuracy might be reduced, in relation to periodontitis, in haemato‐oncologic patients.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35925017</pmid><doi>10.1111/odi.14335</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0107-4939</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Oral diseases, 2024-03, Vol.30 (2), p.624-630 |
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| subjects | Chronic infection Clinical outcomes Dental caries Gum disease Hematological diseases Hematology hematopoietic stem cell transplantation Hematopoietic stem cells leukaemia Leukocytes (neutrophilic) Matrix metalloproteinase Medicin och hälsovetenskap Metalloproteinase MMP‐8 Oral cancer Oral infection Patients Periodontics Periodontitis Plasma levels Stem cell transplantation |
| title | Oral active matrix metalloproteinase‐8 immunotest may be less accurate in haemato‐oncologic patients |
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