AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia–Ischemia Injury

There are sex differences in the severity, mechanisms, and outcomes of neonatal hypoxia–ischemia (HI) brain injury, and apoptosis-inducing factor (AIF) may play a critical role in this discrepancy. Based on previous findings that AIF overexpression aggravates neonatal HI brain injury, we further inv...

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Veröffentlicht in:	Molecular neurobiology 2022-11, Vol.59 (11), p.6613-6631
Hauptverfasser:	Li, Tao, Sun, Yanyan, Zhang, Shan, Xu, Yiran, Li, Kenan, Xie, Cuicui, Wang, Yong, Wang, Yafeng, Cao, Jing, Wang, Xiaoyang, Penninger, Josef M., Kroemer, Guido, Blomgren, Klas, Zhu, Changlian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antioxidants - metabolism Apoptosis Apoptosis Inducing Factor - metabolism Apoptosis-inducing factor Biomedical and Life Sciences Biomedicine Brain injury Carbohydrate metabolism Cell Biology Cell death Dentate gyrus Doublecortin Domain Proteins Doublecortin protein Female Females Gender differences Hypoxia Hypoxia ischemia Hypoxia-Ischemia, Brain - metabolism Ischemia Life Sciences Male Males mechanisms Mice mitochondrial dysfunction Molecular modelling Neonate Neonates Neurobiology Neurogenesis Neurology Neurosciences Neurosciences & Neurology Neurovetenskaper Nitration outcomes Oxidative Stress Sex difference Sex differences Substantia alba Substantia grisea Transgenes Traumatic brain injury
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