Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI

Cell-based therapies offer an exciting and novel treatment for heart repair following myocardial infarction (MI). However, these therapies often suffer from poor cell viability and engraftment rates, which involve many factors, including the hypoxic conditions of the infarct environment. Meanwhile,...

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Veröffentlicht in:	Molecular therapy 2023-01, Vol.31 (1), p.211-229
Hauptverfasser:	Ai, Xuefeng, Yan, Bingqian, Witman, Nevin, Gong, Yiqi, Yang, Li, Tan, Yao, Chen, Ying, Liu, Minglu, Lu, Tingting, Luo, Runjiao, Wang, Huijing, Chien, Kenneth R., Wang, Wei, Fu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cell transplantation Disease Models, Animal heart regeneration Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - transplantation iPSC-CMs modified mRNA Myocardial Infarction - surgery Myocytes, Cardiac - metabolism Original Phosphatidylinositol 3-Kinases - metabolism Rats Stem Cell Transplantation Vascular Endothelial Growth Factor A - metabolism VEGF
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