A Complex Connection Between the Diversity of Human Gastric Mucin O-Glycans, Helicobacter pylori Binding, Helicobacter Infection and Fucosylation

Helicobacter pylori colonizes the stomach of half of the human population. Most H. pylori are located in the mucus layer, which is mainly comprised by glycosylated mucins. Using mass spectrometry, we identified 631 glycans (whereof 145 were fully characterized and the remainder assigned as compositi...

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Veröffentlicht in:	MOLECULAR & CELLULAR PROTEOMICS 2022-11, Vol.21 (11), p.100421-100421, Article 100421
Hauptverfasser:	Chahal, Gurdeep, Padra, Médea, Erhardsson, Mattias, Jin, Chunsheng, Quintana-Hayashi, Macarena, Venkatakrishnan, Vignesh, Padra, János Tamás, Stenbäck, Helen, Thorell, Anders, Karlsson, Niclas G., Lindén, Sara K.
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptation adhesin Adhesins, Bacterial - metabolism baba-mediated adherence Bacterial Adhesion Basic Medicine binding Biochemistry & Molecular Biology core chains epithelium expression Gastric Mucins - metabolism Gastric Mucosa - metabolism glycosylation Helicobacter Infections Helicobacter pylori Helicobacter pylori - metabolism helicobacter-pylori infection human stomach Humans inflammation Medicinska och farmaceutiska grundvetenskaper muc5ac Polysaccharides - metabolism
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