Correlation of SARS-CoV-2 Nasopharyngeal CT Values With Viremia and Mortality in Adults Hospitalized With COVID-19
Abstract Background Both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viremia and nasopharyngeal viral load have been suggested to be predictors of unfavorable outcome in coronavirus disease 2019 (COVID-19). This study aimed to investigate whether nasopharyngeal viral load is correla...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2022-09, Vol.9 (9), p.ofac463-ofac463 |
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| creator | Hagman, Karl Hedenstierna, Magnus Widaeus, Jacob Arvidsson, Emelie Hammas, Berit Grillner, Lena Jakobsson, Jan Gille-Johnson, Patrik Ursing, Johan |
| description | Abstract
Background
Both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viremia and nasopharyngeal viral load have been suggested to be predictors of unfavorable outcome in coronavirus disease 2019 (COVID-19). This study aimed to investigate whether nasopharyngeal viral load is correlated with viremia and unfavorable outcome.
Methods
The presence of SARS-CoV-2 RNA was determined in paired nasopharyngeal and serum samples collected at admission from patients hospitalized for COVID-19. Standardized cycle threshold values (CT values) were used as an indicator of viral load. An adjusted logistic regression was used to estimate the risk of viremia at different nasopharyngeal CT values. A Cox regression was used to estimate the risk of 60-day mortality.
Results
A total of 688 patients were included. Viremia at admission was detected in 63% (146/230), 46% (105/226), and 31% (73/232) of patients with low, intermediate, and high nasopharyngeal CT values. The adjusted odds ratios of being viremic were 4.4 (95% CI, 2.9–6.8) and 2.0 (95% CI, 1.4–3.0) for patients with low and intermediate CT values, compared with high CT values. The 60-day mortality rate was 37% (84/230), 15% (36/226), and 10% (23/232) for patients with low, intermediate, and high nasopharyngeal CT values at admission, respectively. Adjusted hazard ratios were 2.6 (95% CI, 1.6–4.2) and 1.4 (95% CI, 0.8–2.4) for patients with low and intermediate CT values compared with high CT values.
Conclusions
There was a dose-dependent correlation between nasopharyngeal CT values and viremia at admission for COVID-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared with high, nasopharyngeal CT values.
There was a dose-dependent correlation between nasopharyngeal CT-values and viremia in a cohort of 688 patients hospitalised for Covid-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared to high, nasopharyngeal CT-values. |
| doi_str_mv | 10.1093/ofid/ofac463 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_450466</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A775968227</galeid><oup_id>10.1093/ofid/ofac463</oup_id><sourcerecordid>A775968227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c548t-9b9d04a8ddd53ac9ed36b9c0f37ba31e2843e1e106bb036c9072755451fe55453</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEElXpjR_gGxxI6484ji9Iq_DRSoVKtCxHy7EnuwZvnNpZqvLrcZTloweQJc9o_Lyv7PEUxXOCTwmW7Cz0zuZNm6pmj4ojymhTNpKLx3_lT4uTlL5ijAnBHAt5VMQ2xAheTy4MKPToevXpumzDuqToo05h3Op4P2xAe9TeoLX2e0joi5u2aO0i7JxGerDoQ4iT9m66R25AK7v3U0LnIY1urv4Auyjaq_XFm5LIZ8WTXvsEJ4d4XHx-9_amPS8vr95ftKvL0vCqmUrZSYsr3VhrOdNGgmV1Jw3umeg0I0CbigEBguuuw6w2EgsqOK846WEO7LgoF990B-O-U2N0u_waFbRTh9K3nIGqOK7qOvPyn_wYg_0j-iUkuYcCi6bJ2teLNgM7sAaGKWr_0OLByeC2ahO-K8lJQ-ls8PJgEMNtbvKkdi4Z8F4PEPZJUUGxpHVNSUZPF3SjPSg39CE7mrxs_hATBuhdrq-E4LLO3iILXi0CE0NKEfrf9yJYzbOj5tlRh9nJ-IsFD_vx_-RPoKvHgw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2720926621</pqid></control><display><type>article</type><title>Correlation of SARS-CoV-2 Nasopharyngeal CT Values With Viremia and Mortality in Adults Hospitalized With COVID-19</title><source>DOAJ Directory of Open Access Journals</source><source>Access via Oxford University Press (Open Access Collection)</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SWEPUB Freely available online</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>PubMed Central</source><creator>Hagman, Karl ; Hedenstierna, Magnus ; Widaeus, Jacob ; Arvidsson, Emelie ; Hammas, Berit ; Grillner, Lena ; Jakobsson, Jan ; Gille-Johnson, Patrik ; Ursing, Johan</creator><creatorcontrib>Hagman, Karl ; Hedenstierna, Magnus ; Widaeus, Jacob ; Arvidsson, Emelie ; Hammas, Berit ; Grillner, Lena ; Jakobsson, Jan ; Gille-Johnson, Patrik ; Ursing, Johan</creatorcontrib><description>Abstract
Background
Both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viremia and nasopharyngeal viral load have been suggested to be predictors of unfavorable outcome in coronavirus disease 2019 (COVID-19). This study aimed to investigate whether nasopharyngeal viral load is correlated with viremia and unfavorable outcome.
Methods
The presence of SARS-CoV-2 RNA was determined in paired nasopharyngeal and serum samples collected at admission from patients hospitalized for COVID-19. Standardized cycle threshold values (CT values) were used as an indicator of viral load. An adjusted logistic regression was used to estimate the risk of viremia at different nasopharyngeal CT values. A Cox regression was used to estimate the risk of 60-day mortality.
Results
A total of 688 patients were included. Viremia at admission was detected in 63% (146/230), 46% (105/226), and 31% (73/232) of patients with low, intermediate, and high nasopharyngeal CT values. The adjusted odds ratios of being viremic were 4.4 (95% CI, 2.9–6.8) and 2.0 (95% CI, 1.4–3.0) for patients with low and intermediate CT values, compared with high CT values. The 60-day mortality rate was 37% (84/230), 15% (36/226), and 10% (23/232) for patients with low, intermediate, and high nasopharyngeal CT values at admission, respectively. Adjusted hazard ratios were 2.6 (95% CI, 1.6–4.2) and 1.4 (95% CI, 0.8–2.4) for patients with low and intermediate CT values compared with high CT values.
Conclusions
There was a dose-dependent correlation between nasopharyngeal CT values and viremia at admission for COVID-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared with high, nasopharyngeal CT values.
There was a dose-dependent correlation between nasopharyngeal CT-values and viremia in a cohort of 688 patients hospitalised for Covid-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared to high, nasopharyngeal CT-values.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofac463</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adalimumab ; Adults ; Coronaviruses ; Health aspects ; Hospital patients ; Major ; Medicin och hälsovetenskap ; Mortality ; RNA ; Severe acute respiratory syndrome ; Sweden ; Viremia</subject><ispartof>Open Forum Infectious Diseases, 2022-09, Vol.9 (9), p.ofac463-ofac463</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2022</rights><rights>COPYRIGHT 2022 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-9b9d04a8ddd53ac9ed36b9c0f37ba31e2843e1e106bb036c9072755451fe55453</citedby><cites>FETCH-LOGICAL-c548t-9b9d04a8ddd53ac9ed36b9c0f37ba31e2843e1e106bb036c9072755451fe55453</cites><orcidid>0000-0002-5508-9327 ; 0000-0001-8539-9820 ; 0000-0002-5965-6130 ; 0000-0002-5829-1803</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518228/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518228/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,554,729,782,786,866,887,1586,1606,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:150770788$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagman, Karl</creatorcontrib><creatorcontrib>Hedenstierna, Magnus</creatorcontrib><creatorcontrib>Widaeus, Jacob</creatorcontrib><creatorcontrib>Arvidsson, Emelie</creatorcontrib><creatorcontrib>Hammas, Berit</creatorcontrib><creatorcontrib>Grillner, Lena</creatorcontrib><creatorcontrib>Jakobsson, Jan</creatorcontrib><creatorcontrib>Gille-Johnson, Patrik</creatorcontrib><creatorcontrib>Ursing, Johan</creatorcontrib><title>Correlation of SARS-CoV-2 Nasopharyngeal CT Values With Viremia and Mortality in Adults Hospitalized With COVID-19</title><title>Open Forum Infectious Diseases</title><description>Abstract
Background
Both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viremia and nasopharyngeal viral load have been suggested to be predictors of unfavorable outcome in coronavirus disease 2019 (COVID-19). This study aimed to investigate whether nasopharyngeal viral load is correlated with viremia and unfavorable outcome.
Methods
The presence of SARS-CoV-2 RNA was determined in paired nasopharyngeal and serum samples collected at admission from patients hospitalized for COVID-19. Standardized cycle threshold values (CT values) were used as an indicator of viral load. An adjusted logistic regression was used to estimate the risk of viremia at different nasopharyngeal CT values. A Cox regression was used to estimate the risk of 60-day mortality.
Results
A total of 688 patients were included. Viremia at admission was detected in 63% (146/230), 46% (105/226), and 31% (73/232) of patients with low, intermediate, and high nasopharyngeal CT values. The adjusted odds ratios of being viremic were 4.4 (95% CI, 2.9–6.8) and 2.0 (95% CI, 1.4–3.0) for patients with low and intermediate CT values, compared with high CT values. The 60-day mortality rate was 37% (84/230), 15% (36/226), and 10% (23/232) for patients with low, intermediate, and high nasopharyngeal CT values at admission, respectively. Adjusted hazard ratios were 2.6 (95% CI, 1.6–4.2) and 1.4 (95% CI, 0.8–2.4) for patients with low and intermediate CT values compared with high CT values.
Conclusions
There was a dose-dependent correlation between nasopharyngeal CT values and viremia at admission for COVID-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared with high, nasopharyngeal CT values.
There was a dose-dependent correlation between nasopharyngeal CT-values and viremia in a cohort of 688 patients hospitalised for Covid-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared to high, nasopharyngeal CT-values.</description><subject>Adalimumab</subject><subject>Adults</subject><subject>Coronaviruses</subject><subject>Health aspects</subject><subject>Hospital patients</subject><subject>Major</subject><subject>Medicin och hälsovetenskap</subject><subject>Mortality</subject><subject>RNA</subject><subject>Severe acute respiratory syndrome</subject><subject>Sweden</subject><subject>Viremia</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>D8T</sourceid><recordid>eNp9kk1v1DAQhiMEElXpjR_gGxxI6484ji9Iq_DRSoVKtCxHy7EnuwZvnNpZqvLrcZTloweQJc9o_Lyv7PEUxXOCTwmW7Cz0zuZNm6pmj4ojymhTNpKLx3_lT4uTlL5ijAnBHAt5VMQ2xAheTy4MKPToevXpumzDuqToo05h3Op4P2xAe9TeoLX2e0joi5u2aO0i7JxGerDoQ4iT9m66R25AK7v3U0LnIY1urv4Auyjaq_XFm5LIZ8WTXvsEJ4d4XHx-9_amPS8vr95ftKvL0vCqmUrZSYsr3VhrOdNGgmV1Jw3umeg0I0CbigEBguuuw6w2EgsqOK846WEO7LgoF990B-O-U2N0u_waFbRTh9K3nIGqOK7qOvPyn_wYg_0j-iUkuYcCi6bJ2teLNgM7sAaGKWr_0OLByeC2ahO-K8lJQ-ls8PJgEMNtbvKkdi4Z8F4PEPZJUUGxpHVNSUZPF3SjPSg39CE7mrxs_hATBuhdrq-E4LLO3iILXi0CE0NKEfrf9yJYzbOj5tlRh9nJ-IsFD_vx_-RPoKvHgw</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Hagman, Karl</creator><creator>Hedenstierna, Magnus</creator><creator>Widaeus, Jacob</creator><creator>Arvidsson, Emelie</creator><creator>Hammas, Berit</creator><creator>Grillner, Lena</creator><creator>Jakobsson, Jan</creator><creator>Gille-Johnson, Patrik</creator><creator>Ursing, Johan</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-5508-9327</orcidid><orcidid>https://orcid.org/0000-0001-8539-9820</orcidid><orcidid>https://orcid.org/0000-0002-5965-6130</orcidid><orcidid>https://orcid.org/0000-0002-5829-1803</orcidid></search><sort><creationdate>20220901</creationdate><title>Correlation of SARS-CoV-2 Nasopharyngeal CT Values With Viremia and Mortality in Adults Hospitalized With COVID-19</title><author>Hagman, Karl ; Hedenstierna, Magnus ; Widaeus, Jacob ; Arvidsson, Emelie ; Hammas, Berit ; Grillner, Lena ; Jakobsson, Jan ; Gille-Johnson, Patrik ; Ursing, Johan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-9b9d04a8ddd53ac9ed36b9c0f37ba31e2843e1e106bb036c9072755451fe55453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adalimumab</topic><topic>Adults</topic><topic>Coronaviruses</topic><topic>Health aspects</topic><topic>Hospital patients</topic><topic>Major</topic><topic>Medicin och hälsovetenskap</topic><topic>Mortality</topic><topic>RNA</topic><topic>Severe acute respiratory syndrome</topic><topic>Sweden</topic><topic>Viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagman, Karl</creatorcontrib><creatorcontrib>Hedenstierna, Magnus</creatorcontrib><creatorcontrib>Widaeus, Jacob</creatorcontrib><creatorcontrib>Arvidsson, Emelie</creatorcontrib><creatorcontrib>Hammas, Berit</creatorcontrib><creatorcontrib>Grillner, Lena</creatorcontrib><creatorcontrib>Jakobsson, Jan</creatorcontrib><creatorcontrib>Gille-Johnson, Patrik</creatorcontrib><creatorcontrib>Ursing, Johan</creatorcontrib><collection>Access via Oxford University Press (Open Access Collection)</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagman, Karl</au><au>Hedenstierna, Magnus</au><au>Widaeus, Jacob</au><au>Arvidsson, Emelie</au><au>Hammas, Berit</au><au>Grillner, Lena</au><au>Jakobsson, Jan</au><au>Gille-Johnson, Patrik</au><au>Ursing, Johan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of SARS-CoV-2 Nasopharyngeal CT Values With Viremia and Mortality in Adults Hospitalized With COVID-19</atitle><jtitle>Open Forum Infectious Diseases</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>9</volume><issue>9</issue><spage>ofac463</spage><epage>ofac463</epage><pages>ofac463-ofac463</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Background
Both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viremia and nasopharyngeal viral load have been suggested to be predictors of unfavorable outcome in coronavirus disease 2019 (COVID-19). This study aimed to investigate whether nasopharyngeal viral load is correlated with viremia and unfavorable outcome.
Methods
The presence of SARS-CoV-2 RNA was determined in paired nasopharyngeal and serum samples collected at admission from patients hospitalized for COVID-19. Standardized cycle threshold values (CT values) were used as an indicator of viral load. An adjusted logistic regression was used to estimate the risk of viremia at different nasopharyngeal CT values. A Cox regression was used to estimate the risk of 60-day mortality.
Results
A total of 688 patients were included. Viremia at admission was detected in 63% (146/230), 46% (105/226), and 31% (73/232) of patients with low, intermediate, and high nasopharyngeal CT values. The adjusted odds ratios of being viremic were 4.4 (95% CI, 2.9–6.8) and 2.0 (95% CI, 1.4–3.0) for patients with low and intermediate CT values, compared with high CT values. The 60-day mortality rate was 37% (84/230), 15% (36/226), and 10% (23/232) for patients with low, intermediate, and high nasopharyngeal CT values at admission, respectively. Adjusted hazard ratios were 2.6 (95% CI, 1.6–4.2) and 1.4 (95% CI, 0.8–2.4) for patients with low and intermediate CT values compared with high CT values.
Conclusions
There was a dose-dependent correlation between nasopharyngeal CT values and viremia at admission for COVID-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared with high, nasopharyngeal CT values.
There was a dose-dependent correlation between nasopharyngeal CT-values and viremia in a cohort of 688 patients hospitalised for Covid-19. Moreover, there was an increased risk of 60-day mortality for patients with low, compared to high, nasopharyngeal CT-values.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/ofid/ofac463</doi><orcidid>https://orcid.org/0000-0002-5508-9327</orcidid><orcidid>https://orcid.org/0000-0001-8539-9820</orcidid><orcidid>https://orcid.org/0000-0002-5965-6130</orcidid><orcidid>https://orcid.org/0000-0002-5829-1803</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Access via Oxford University Press (Open Access Collection); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Oxford University Press Journals All Titles (1996-Current); PubMed Central |
| subjects | Adalimumab Adults Coronaviruses Health aspects Hospital patients Major Medicin och hälsovetenskap Mortality RNA Severe acute respiratory syndrome Sweden Viremia |
| title | Correlation of SARS-CoV-2 Nasopharyngeal CT Values With Viremia and Mortality in Adults Hospitalized With COVID-19 |
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