SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that SARS-CoV-2 infection initiate neuronal cell...

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Veröffentlicht in:	Molecular psychiatry 2022-10, Vol.27 (10), p.3939-3950
Hauptverfasser:	Samudyata, Oliveira, Ana O., Malwade, Susmita, Rufino de Sousa, Nuno, Goparaju, Sravan K., Gracias, Jessica, Orhan, Funda, Steponaviciute, Laura, Schalling, Martin, Sheridan, Steven D., Perlis, Roy H., Rothfuchs, Antonio G., Sellgren, Carl M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/19 38/1 38/39 631/378 631/80 Behavioral Sciences Biological Psychology Brain Cell death Cognitive ability COVID-19 Humans Immediate Communication Infections Interferon Medicine Medicine & Public Health Microglia Neurodegenerative diseases Neurosciences Organoids Pharmacotherapy Presynaptic Terminals Psychiatry SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Synapse elimination Synapses Transcriptomics
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