European consensus for the diagnosis of MCI and mild dementia: Preparatory phase
Introduction Etiological diagnosis of neurocognitive disorders of middle‐old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization...
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| Veröffentlicht in: | Alzheimer's & dementia 2023-05, Vol.19 (5), p.1729-1741 |
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| creator | Festari, Cristina Massa, Federico Cotta Ramusino, Matteo Gandolfo, Federica Nicolosi, Valentina Orini, Stefania Aarsland, Dag Agosta, Federica Babiloni, Claudio Boada, Mercè Borroni, Barbara Cappa, Stefano Dubois, Bruno Frederiksen, Kristian S. Froelich, Lutz Garibotto, Valentina Georges, Jean Haliassos, Alexander Hansson, Oskar Jessen, Frank Kamondi, Anita Kessels, Roy P. C. Morbelli, Silvia O'Brien, John T. Otto, Markus Perret‐Liaudet, Armand Pizzini, Francesca B. Ritchie, Craig W. Scheltens, Philip Vandenbulcke, Mathieu Vanninen, Ritva Verhey, Frans Vernooij, Meike W. Yousry, Tarek Van Der Flier, Wiesje M. Nobili, Flavio Frisoni, Giovanni B. |
| description | Introduction
Etiological diagnosis of neurocognitive disorders of middle‐old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results.
Methods
Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions.
Results
We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI‐mild dementia), and detailed pre‐assessment screening (clinical‐neuropsychological evaluations, brain imaging, and blood tests).
Discussion
The Delphi consensus on these assumptions set the stage for the development of the first pan‐European workflow for biomarkers’ use in the etiological diagnosis of middle‐old age neurocognitive disorders at MCI‐mild dementia stages.
Highlights
Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe.
A consensus of experts will define a workflow for the rational use of biomarkers.
The diagnostic workflow will be patient‐centered and based on clinical presentation.
The workflow will be updated as new evidence accrues. |
| doi_str_mv | 10.1002/alz.12798 |
| format | Article |
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Etiological diagnosis of neurocognitive disorders of middle‐old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results.
Methods
Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions.
Results
We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI‐mild dementia), and detailed pre‐assessment screening (clinical‐neuropsychological evaluations, brain imaging, and blood tests).
Discussion
The Delphi consensus on these assumptions set the stage for the development of the first pan‐European workflow for biomarkers’ use in the etiological diagnosis of middle‐old age neurocognitive disorders at MCI‐mild dementia stages.
Highlights
Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe.
A consensus of experts will define a workflow for the rational use of biomarkers.
The diagnostic workflow will be patient‐centered and based on clinical presentation.
The workflow will be updated as new evidence accrues.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.12798</identifier><identifier>PMID: 36209379</identifier><language>eng</language><publisher>United States: Alzheimer's Association / Wiley</publisher><subject>Biomarkers ; Clinical Medicine ; Cognitive Dysfunction - diagnosis ; Consensus ; Delphi procedure ; Dementia - diagnosis ; etiological diagnosis ; Human health and pathology ; Humans ; imaging ; Klinisk medicin ; Life Sciences ; major neurocognitive disorder ; MCI ; Medical and Health Sciences ; Medicin och hälsovetenskap ; mild dementia – biomarker ; neurocognitive disorders ; Neurologi ; Neurology ; Neurons and Cognition ; Psychiatrics and mental health ; Sensitivity and Specificity</subject><ispartof>Alzheimer's & dementia, 2023-05, Vol.19 (5), p.1729-1741</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><rights>2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><rights>Attribution - NonCommercial - NoDerivatives</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5018-cd04931e717c42fe43142d03e701e63033c4db6486a83c2755e5c88eeac79b653</citedby><cites>FETCH-LOGICAL-c5018-cd04931e717c42fe43142d03e701e63033c4db6486a83c2755e5c88eeac79b653</cites><orcidid>0000-0001-6712-9018</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falz.12798$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falz.12798$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36209379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04403063$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/891a4b65-e365-4ac6-9a22-bd6f1074d132$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:150888678$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Festari, Cristina</creatorcontrib><creatorcontrib>Massa, Federico</creatorcontrib><creatorcontrib>Cotta Ramusino, Matteo</creatorcontrib><creatorcontrib>Gandolfo, Federica</creatorcontrib><creatorcontrib>Nicolosi, Valentina</creatorcontrib><creatorcontrib>Orini, Stefania</creatorcontrib><creatorcontrib>Aarsland, Dag</creatorcontrib><creatorcontrib>Agosta, Federica</creatorcontrib><creatorcontrib>Babiloni, Claudio</creatorcontrib><creatorcontrib>Boada, Mercè</creatorcontrib><creatorcontrib>Borroni, Barbara</creatorcontrib><creatorcontrib>Cappa, Stefano</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Frederiksen, Kristian S.</creatorcontrib><creatorcontrib>Froelich, Lutz</creatorcontrib><creatorcontrib>Garibotto, Valentina</creatorcontrib><creatorcontrib>Georges, Jean</creatorcontrib><creatorcontrib>Haliassos, Alexander</creatorcontrib><creatorcontrib>Hansson, Oskar</creatorcontrib><creatorcontrib>Jessen, Frank</creatorcontrib><creatorcontrib>Kamondi, Anita</creatorcontrib><creatorcontrib>Kessels, Roy P. C.</creatorcontrib><creatorcontrib>Morbelli, Silvia</creatorcontrib><creatorcontrib>O'Brien, John T.</creatorcontrib><creatorcontrib>Otto, Markus</creatorcontrib><creatorcontrib>Perret‐Liaudet, Armand</creatorcontrib><creatorcontrib>Pizzini, Francesca B.</creatorcontrib><creatorcontrib>Ritchie, Craig W.</creatorcontrib><creatorcontrib>Scheltens, Philip</creatorcontrib><creatorcontrib>Vandenbulcke, Mathieu</creatorcontrib><creatorcontrib>Vanninen, Ritva</creatorcontrib><creatorcontrib>Verhey, Frans</creatorcontrib><creatorcontrib>Vernooij, Meike W.</creatorcontrib><creatorcontrib>Yousry, Tarek</creatorcontrib><creatorcontrib>Van Der Flier, Wiesje M.</creatorcontrib><creatorcontrib>Nobili, Flavio</creatorcontrib><creatorcontrib>Frisoni, Giovanni B.</creatorcontrib><title>European consensus for the diagnosis of MCI and mild dementia: Preparatory phase</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Introduction
Etiological diagnosis of neurocognitive disorders of middle‐old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results.
Methods
Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions.
Results
We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI‐mild dementia), and detailed pre‐assessment screening (clinical‐neuropsychological evaluations, brain imaging, and blood tests).
Discussion
The Delphi consensus on these assumptions set the stage for the development of the first pan‐European workflow for biomarkers’ use in the etiological diagnosis of middle‐old age neurocognitive disorders at MCI‐mild dementia stages.
Highlights
Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe.
A consensus of experts will define a workflow for the rational use of biomarkers.
The diagnostic workflow will be patient‐centered and based on clinical presentation.
The workflow will be updated as new evidence accrues.</description><subject>Biomarkers</subject><subject>Clinical Medicine</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Consensus</subject><subject>Delphi procedure</subject><subject>Dementia - diagnosis</subject><subject>etiological diagnosis</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>imaging</subject><subject>Klinisk medicin</subject><subject>Life Sciences</subject><subject>major neurocognitive disorder</subject><subject>MCI</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>mild dementia – biomarker</subject><subject>neurocognitive disorders</subject><subject>Neurologi</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Psychiatrics and mental health</subject><subject>Sensitivity and Specificity</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kU1v1DAQhiMEoqVw4A8gH-GQdvydcFutCq0URA9w4WI59oQNZONgb6iWX4-XLIs49DD2ePTM48NbFC8pXFIAdmWHX5eU6bp6VJxTKVkp8-PxqVdwVjxL6RuAgIrKp8UZVwxqruvz4u56jmFCOxIXxoRjmhPpQiS7DRLf269jSH0ioSMf1rfEjp5s-8ETj1scd719S-4iTjbaXYh7Mm1swufFk84OCV8c74vi87vrT-ubsvn4_na9akongVal8yBqTlFT7QTrUHAqmAeOGigqDpw74VslKmUr7piWEqWrKkTrdN0qyS-KcvGme5zm1kyx39q4N8H25jj6njs0QgKXKvPNg_wwT7naXIeFqqZW5C8M8nwI65SpLWOm9aqjoIWnnGXdm0W3scN_rptVYw4zEAI4KP6TZvb1wk4x_Jgx7cy2Tw6HwY4Y5mSYZpwqkEL_07oYUorYndwUzCFrk7M2f7LO7Kujdm636E_k33AzcLUA9_2A-4dNZtV8WZS_AdpRsNY</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Festari, Cristina</creator><creator>Massa, Federico</creator><creator>Cotta Ramusino, Matteo</creator><creator>Gandolfo, Federica</creator><creator>Nicolosi, Valentina</creator><creator>Orini, Stefania</creator><creator>Aarsland, Dag</creator><creator>Agosta, Federica</creator><creator>Babiloni, Claudio</creator><creator>Boada, Mercè</creator><creator>Borroni, Barbara</creator><creator>Cappa, Stefano</creator><creator>Dubois, Bruno</creator><creator>Frederiksen, Kristian S.</creator><creator>Froelich, Lutz</creator><creator>Garibotto, Valentina</creator><creator>Georges, Jean</creator><creator>Haliassos, Alexander</creator><creator>Hansson, Oskar</creator><creator>Jessen, Frank</creator><creator>Kamondi, Anita</creator><creator>Kessels, Roy P. C.</creator><creator>Morbelli, Silvia</creator><creator>O'Brien, John T.</creator><creator>Otto, Markus</creator><creator>Perret‐Liaudet, Armand</creator><creator>Pizzini, Francesca B.</creator><creator>Ritchie, Craig W.</creator><creator>Scheltens, Philip</creator><creator>Vandenbulcke, Mathieu</creator><creator>Vanninen, Ritva</creator><creator>Verhey, Frans</creator><creator>Vernooij, Meike W.</creator><creator>Yousry, Tarek</creator><creator>Van Der Flier, Wiesje M.</creator><creator>Nobili, Flavio</creator><creator>Frisoni, Giovanni B.</creator><general>Alzheimer's Association / Wiley</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0001-6712-9018</orcidid></search><sort><creationdate>202305</creationdate><title>European consensus for the diagnosis of MCI and mild dementia: Preparatory phase</title><author>Festari, Cristina ; Massa, Federico ; Cotta Ramusino, Matteo ; Gandolfo, Federica ; Nicolosi, Valentina ; Orini, Stefania ; Aarsland, Dag ; Agosta, Federica ; Babiloni, Claudio ; Boada, Mercè ; Borroni, Barbara ; Cappa, Stefano ; Dubois, Bruno ; Frederiksen, Kristian S. ; Froelich, Lutz ; Garibotto, Valentina ; Georges, Jean ; Haliassos, Alexander ; Hansson, Oskar ; Jessen, Frank ; Kamondi, Anita ; Kessels, Roy P. C. ; Morbelli, Silvia ; O'Brien, John T. ; Otto, Markus ; Perret‐Liaudet, Armand ; Pizzini, Francesca B. ; Ritchie, Craig W. ; Scheltens, Philip ; Vandenbulcke, Mathieu ; Vanninen, Ritva ; Verhey, Frans ; Vernooij, Meike W. ; Yousry, Tarek ; Van Der Flier, Wiesje M. ; Nobili, Flavio ; Frisoni, Giovanni B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5018-cd04931e717c42fe43142d03e701e63033c4db6486a83c2755e5c88eeac79b653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomarkers</topic><topic>Clinical Medicine</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Consensus</topic><topic>Delphi procedure</topic><topic>Dementia - diagnosis</topic><topic>etiological diagnosis</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>imaging</topic><topic>Klinisk medicin</topic><topic>Life Sciences</topic><topic>major neurocognitive disorder</topic><topic>MCI</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>mild dementia – biomarker</topic><topic>neurocognitive disorders</topic><topic>Neurologi</topic><topic>Neurology</topic><topic>Neurons and Cognition</topic><topic>Psychiatrics and mental health</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Festari, Cristina</creatorcontrib><creatorcontrib>Massa, Federico</creatorcontrib><creatorcontrib>Cotta Ramusino, Matteo</creatorcontrib><creatorcontrib>Gandolfo, Federica</creatorcontrib><creatorcontrib>Nicolosi, Valentina</creatorcontrib><creatorcontrib>Orini, Stefania</creatorcontrib><creatorcontrib>Aarsland, Dag</creatorcontrib><creatorcontrib>Agosta, Federica</creatorcontrib><creatorcontrib>Babiloni, Claudio</creatorcontrib><creatorcontrib>Boada, Mercè</creatorcontrib><creatorcontrib>Borroni, Barbara</creatorcontrib><creatorcontrib>Cappa, Stefano</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Frederiksen, Kristian S.</creatorcontrib><creatorcontrib>Froelich, Lutz</creatorcontrib><creatorcontrib>Garibotto, Valentina</creatorcontrib><creatorcontrib>Georges, Jean</creatorcontrib><creatorcontrib>Haliassos, Alexander</creatorcontrib><creatorcontrib>Hansson, Oskar</creatorcontrib><creatorcontrib>Jessen, Frank</creatorcontrib><creatorcontrib>Kamondi, Anita</creatorcontrib><creatorcontrib>Kessels, Roy P. C.</creatorcontrib><creatorcontrib>Morbelli, Silvia</creatorcontrib><creatorcontrib>O'Brien, John T.</creatorcontrib><creatorcontrib>Otto, Markus</creatorcontrib><creatorcontrib>Perret‐Liaudet, Armand</creatorcontrib><creatorcontrib>Pizzini, Francesca B.</creatorcontrib><creatorcontrib>Ritchie, Craig W.</creatorcontrib><creatorcontrib>Scheltens, Philip</creatorcontrib><creatorcontrib>Vandenbulcke, Mathieu</creatorcontrib><creatorcontrib>Vanninen, Ritva</creatorcontrib><creatorcontrib>Verhey, Frans</creatorcontrib><creatorcontrib>Vernooij, Meike W.</creatorcontrib><creatorcontrib>Yousry, Tarek</creatorcontrib><creatorcontrib>Van Der Flier, Wiesje M.</creatorcontrib><creatorcontrib>Nobili, Flavio</creatorcontrib><creatorcontrib>Frisoni, Giovanni B.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Festari, Cristina</au><au>Massa, Federico</au><au>Cotta Ramusino, Matteo</au><au>Gandolfo, Federica</au><au>Nicolosi, Valentina</au><au>Orini, Stefania</au><au>Aarsland, Dag</au><au>Agosta, Federica</au><au>Babiloni, Claudio</au><au>Boada, Mercè</au><au>Borroni, Barbara</au><au>Cappa, Stefano</au><au>Dubois, Bruno</au><au>Frederiksen, Kristian S.</au><au>Froelich, Lutz</au><au>Garibotto, Valentina</au><au>Georges, Jean</au><au>Haliassos, Alexander</au><au>Hansson, Oskar</au><au>Jessen, Frank</au><au>Kamondi, Anita</au><au>Kessels, Roy P. C.</au><au>Morbelli, Silvia</au><au>O'Brien, John T.</au><au>Otto, Markus</au><au>Perret‐Liaudet, Armand</au><au>Pizzini, Francesca B.</au><au>Ritchie, Craig W.</au><au>Scheltens, Philip</au><au>Vandenbulcke, Mathieu</au><au>Vanninen, Ritva</au><au>Verhey, Frans</au><au>Vernooij, Meike W.</au><au>Yousry, Tarek</au><au>Van Der Flier, Wiesje M.</au><au>Nobili, Flavio</au><au>Frisoni, Giovanni B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>European consensus for the diagnosis of MCI and mild dementia: Preparatory phase</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2023-05</date><risdate>2023</risdate><volume>19</volume><issue>5</issue><spage>1729</spage><epage>1741</epage><pages>1729-1741</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Introduction
Etiological diagnosis of neurocognitive disorders of middle‐old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results.
Methods
Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions.
Results
We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI‐mild dementia), and detailed pre‐assessment screening (clinical‐neuropsychological evaluations, brain imaging, and blood tests).
Discussion
The Delphi consensus on these assumptions set the stage for the development of the first pan‐European workflow for biomarkers’ use in the etiological diagnosis of middle‐old age neurocognitive disorders at MCI‐mild dementia stages.
Highlights
Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe.
A consensus of experts will define a workflow for the rational use of biomarkers.
The diagnostic workflow will be patient‐centered and based on clinical presentation.
The workflow will be updated as new evidence accrues.</abstract><cop>United States</cop><pub>Alzheimer's Association / Wiley</pub><pmid>36209379</pmid><doi>10.1002/alz.12798</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-6712-9018</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-5260 |
| ispartof | Alzheimer's & dementia, 2023-05, Vol.19 (5), p.1729-1741 |
| issn | 1552-5260 1552-5279 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_450356 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | Biomarkers Clinical Medicine Cognitive Dysfunction - diagnosis Consensus Delphi procedure Dementia - diagnosis etiological diagnosis Human health and pathology Humans imaging Klinisk medicin Life Sciences major neurocognitive disorder MCI Medical and Health Sciences Medicin och hälsovetenskap mild dementia – biomarker neurocognitive disorders Neurologi Neurology Neurons and Cognition Psychiatrics and mental health Sensitivity and Specificity |
| title | European consensus for the diagnosis of MCI and mild dementia: Preparatory phase |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T23%3A01%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=European%20consensus%20for%20the%20diagnosis%20of%20MCI%20and%20mild%20dementia:%20Preparatory%20phase&rft.jtitle=Alzheimer's%20&%20dementia&rft.au=Festari,%20Cristina&rft.date=2023-05&rft.volume=19&rft.issue=5&rft.spage=1729&rft.epage=1741&rft.pages=1729-1741&rft.issn=1552-5260&rft.eissn=1552-5279&rft_id=info:doi/10.1002/alz.12798&rft_dat=%3Cproquest_swepu%3E2723160547%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2723160547&rft_id=info:pmid/36209379&rfr_iscdi=true |