Effect of CYP2C19 polymorphisms on antidepressant prescription patterns and treatment emergent mania in bipolar disorder

Antidepressant medication is used extensively to treat bipolar depression despite uncertain efficacy. The cytochrome P450 (CYP) 2C19 enzyme metabolize several antidepressants, and polymorphisms in the corresponding gene CYP2C19 influence plasma concentration and hence treatment outcomes in major dep...

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Veröffentlicht in:	The pharmacogenomics journal 2023-01, Vol.23 (1), p.28-35
Hauptverfasser:	Joas, Erik, Jonsson, Lina, Viktorin, Alexander, Smedler, Erik, Pålsson, Erik, Goodwin, Guy M., Landén, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 692/308/2056 692/308/409 Affective disorders Amitriptyline Amitriptyline - therapeutic use Antidepressants Antidepressive Agents - adverse effects Biomedical and Life Sciences Biomedicine Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - genetics Citalopram Clinical outcomes Clomipramine Clomipramine - therapeutic use Cytochrome P-450 CYP2C19 - genetics Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Depressive Disorder, Major - drug therapy Gene Expression Human Genetics Humans Mania - chemically induced Mania - drug therapy Medical Genetics Medicinsk genetik Mental depression Metabolism Oncology Pharmacotherapy Phenotypes Polymorphism, Single Nucleotide - genetics Psychiatry Psychopharmacology Psykiatri Sertraline Single-nucleotide polymorphism Tricyclic antidepressants
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