Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia

Phosphatidylinositol 3-kinase catalytic subunit p110β is involved in tumorigenesis and hemostasis. However, it remains unclear if p110β also regulates platelet-mediated immune responses, which could have important consequences for immune modulation during anti-cancer treatment with p110β inhibitors....

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Veröffentlicht in:	Cell reports (Cambridge) 2022-11, Vol.41 (6), p.111614, Article 111614
Hauptverfasser:	Schrottmaier, Waltraud Cornelia, Kral-Pointner, Julia Barbara, Salzmann, Manuel, Mussbacher, Marion, Schmuckenschlager, Anna, Pirabe, Anita, Brunnthaler, Laura, Kuttke, Mario, Maier, Barbara, Heber, Stefan, Datler, Hannes, Ekici, Yasemin, Niederreiter, Birgit, Heber, Ulrike, Blomgren, Bo, Gorki, Anna-Dorothea, Söderberg-Nauclér, Cecilia, Payrastre, Bernard, Gratacap, Marie-Pierre, Knapp, Sylvia, Schabbauer, Gernot, Assinger, Alice
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets Humans immunomodulation infection inflammation leukocyte recruitment Leukocytes Life Sciences p110 inhibitor Phosphatidylinositol 3-Kinases - genetics Phosphoinositide-3 Kinase Inhibitors PI3K platelet pneumonia Pneumonia, Pneumococcal streptococcus Streptococcus pneumoniae
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