Generation of NK cells with chimeric-switch receptors to overcome PD1-mediated inhibition in cancer immunotherapy

Multiple myeloma (MM) is an incurable hematological cancer, in which immune checkpoint inhibition (ICI) with monoclonal antibodies (mAbs) has failed due to uncontrollable immune responses in combination therapies and lack of efficacy in monotherapies. Although NK cell-specific checkpoint targets suc...

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Veröffentlicht in:	CANCER IMMUNOLOGY, IMMUNOTHERAPY IMMUNOTHERAPY, 2023-05, Vol.72 (5), p.1153-1167
Hauptverfasser:	Susek, Katharina H., Schwietzer, Ysabel A., Karvouni, Maria, Gilljam, Mari, Keszei, Marton, Hussain, Alamdar, Lund, Johan, Kashif, Muhammad, Lundqvist, Andreas, Ljunggren, Hans-Gustaf, Nahi, Hareth, Wagner, Arnika K., Alici, Evren
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor agents B7-H1 Antigen - metabolism Blood cancer Cancer immunotherapy Cancer Research Cell death Cell recognition Clinical trials Cytokines Cytokines - metabolism Cytotoxicity DAP10 protein DAP12 protein Degranulation Effector cells Humans Immune checkpoint inhibitors Immunology Immunotherapy Immunotherapy - methods Killer Cells, Natural Ligands Lymphocytes T Medicin och hälsovetenskap Medicine Medicine & Public Health Microenvironments Monoclonal antibodies Multiple Myeloma Natural killer cells NKG2 antigen Oncology PD-1 protein PD-L1 protein Plasma cells Receptors, Natural Killer Cell - metabolism Spheroids Tumor Microenvironment
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