The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets
Scope The fatty acid composition of plasma lipids, which is associated with biomarkers and risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS). We investigated the interactions between dietary PUFAs and FADS1 rs1...
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| Veröffentlicht in: | Molecular nutrition & food research 2022-12, Vol.66 (24), p.e2200351-n/a |
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| creator | Meuronen, Topi Lankinen, Maria A. Kolmert, Johan de Mello, Vanessa Derenji Sallinen, Taisa Ågren, Jyrki Virtanen, Kirsi A. Laakso, Markku Wheelock, Craig E. Pihlajamäki, Jussi Schwab, Ursula |
| description | Scope
The fatty acid composition of plasma lipids, which is associated with biomarkers and risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS). We investigated the interactions between dietary PUFAs and FADS1 rs174550 variant.
Methods and results
Participants (n = 118), homozygous for FADS1 rs174550 variant (TT and CC) followed a high alpha‐linolenic acid (ALA, 5 percent of energy (E‐%)) or a high linoleic acid (LA, 10 E‐%) diet during an 8‐week randomized controlled intervention. Fatty acid composition of plasma lipids and PUFA‐derived lipid mediators were quantified by gas and liquid chromatography mass spectrometry, respectively. The high‐LA diet increased the concentration of plasma LA, but not its lipid mediators. The concentration of plasma arachidonic acid decreased in carriers of CC and remained unchanged in the TT genotype. The high‐ALA diet increased the concentration of plasma ALA and its cytochrome P450‐derived epoxides and dihydroxys, and cyclooxygenase‐derived monohydroxys. Concentrations of plasma eicosapentaenoic acid and its mono‐ and dihydroxys increased only in TT genotype carriers.
Conclusions
These findings suggest the potential for genotype‐based recommendations for PUFA consumption, resulting in modulation of bioactive lipid mediators which can exert beneficial effects in maintaining health.
This study aimed to explore the differences in the plasma fatty acid and lipid mediator concentrations in response to dietary polyunsaturated fatty acids (PUFA) between carriers of the FADS1 rs174550 TT and CC genotypes. Plasma concentrations of long‐chain PUFAs and their derived bioactive lipid mediators changed in a genotype dependent manner in response to linoleic and alpha‐linolenic acid enriched diets. |
| doi_str_mv | 10.1002/mnfr.202200351 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_449649</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2735864837</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5027-3af8ba592ee5f96c4cb57042dca2d82da3f09350e770b76a0e88c6fda5b0ce3d3</originalsourceid><addsrcrecordid>eNqFkk1vEzEQhlcIREvhyhFZ4sJlgz_XuycUtaRFSgCV9mx57dnGZWMv6w1VbvwEjvw-fglONo0oF04ezzzvO_6YLHtJ8IRgTN-ufNNPKKYUYybIo-yYFITlnDD2-BBTcZQ9i_E2IYRy9jQ7YgUrJGX8OPt1tQQ0m559IaiPRHIhMDoHH4ZNB2gRrGscRDQkyP_-8ZMh7e0uKtDn69l0t527zlm0AOv0EHp0CbELPm5VAWl04W6WaNp2S51Uc-dDC94ZNDVJs1Xv6mP-Pn3mYIjPsyeNbiO82K8n2fXs_dXpRT7_dP7hdDrPjcBU5kw3Za1FRQFEUxWGm1pIzKk1mtqSWs0aXDGBQUpcy0JjKEtTNFaLGhtglp1k-egb76Bb16rr3Ur3GxW0U_vU1xSB4rwqeJX4dyOfKiuwBvzQ6_aB7GHFu6W6Cd9V-i4py6pMDm_2Dn34toY4qJWLBtpWewjrqKhkoix4yWRCX_-D3oZ179N7JErwkhIpaKImI2X6EGMPzeE0BG_bUrWdEnWYkiR49fcdDvj9WCSAj8Cda2HzHzu1-Di75IxL9gfIU8pZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2754821752</pqid></control><display><type>article</type><title>The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SWEPUB Freely available online</source><creator>Meuronen, Topi ; Lankinen, Maria A. ; Kolmert, Johan ; de Mello, Vanessa Derenji ; Sallinen, Taisa ; Ågren, Jyrki ; Virtanen, Kirsi A. ; Laakso, Markku ; Wheelock, Craig E. ; Pihlajamäki, Jussi ; Schwab, Ursula</creator><creatorcontrib>Meuronen, Topi ; Lankinen, Maria A. ; Kolmert, Johan ; de Mello, Vanessa Derenji ; Sallinen, Taisa ; Ågren, Jyrki ; Virtanen, Kirsi A. ; Laakso, Markku ; Wheelock, Craig E. ; Pihlajamäki, Jussi ; Schwab, Ursula</creatorcontrib><description>Scope
The fatty acid composition of plasma lipids, which is associated with biomarkers and risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS). We investigated the interactions between dietary PUFAs and FADS1 rs174550 variant.
Methods and results
Participants (n = 118), homozygous for FADS1 rs174550 variant (TT and CC) followed a high alpha‐linolenic acid (ALA, 5 percent of energy (E‐%)) or a high linoleic acid (LA, 10 E‐%) diet during an 8‐week randomized controlled intervention. Fatty acid composition of plasma lipids and PUFA‐derived lipid mediators were quantified by gas and liquid chromatography mass spectrometry, respectively. The high‐LA diet increased the concentration of plasma LA, but not its lipid mediators. The concentration of plasma arachidonic acid decreased in carriers of CC and remained unchanged in the TT genotype. The high‐ALA diet increased the concentration of plasma ALA and its cytochrome P450‐derived epoxides and dihydroxys, and cyclooxygenase‐derived monohydroxys. Concentrations of plasma eicosapentaenoic acid and its mono‐ and dihydroxys increased only in TT genotype carriers.
Conclusions
These findings suggest the potential for genotype‐based recommendations for PUFA consumption, resulting in modulation of bioactive lipid mediators which can exert beneficial effects in maintaining health.
This study aimed to explore the differences in the plasma fatty acid and lipid mediator concentrations in response to dietary polyunsaturated fatty acids (PUFA) between carriers of the FADS1 rs174550 TT and CC genotypes. Plasma concentrations of long‐chain PUFAs and their derived bioactive lipid mediators changed in a genotype dependent manner in response to linoleic and alpha‐linolenic acid enriched diets.</description><identifier>ISSN: 1613-4125</identifier><identifier>ISSN: 1613-4133</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.202200351</identifier><identifier>PMID: 36367234</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>alpha-Linolenic Acid ; Arachidonic acid ; Biomarkers ; Composition ; Cytochrome ; Cytochrome P450 ; Cytochromes P450 ; Desaturase ; Diet ; eicosanoid ; Eicosapentaenoic acid ; Epoxides ; FADS ; Fatty acid composition ; Fatty Acid Desaturases - genetics ; Fatty Acids ; Fatty Acids, Unsaturated ; Genotype ; Genotype & phenotype ; Genotypes ; Health risks ; Humans ; Linoleic Acid ; Linolenic acid ; Lipids ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; octadecanoid ; Plasma ; Polymorphism, Single Nucleotide ; Polyunsaturated fatty acids ; Prostaglandin endoperoxide synthase</subject><ispartof>Molecular nutrition & food research, 2022-12, Vol.66 (24), p.e2200351-n/a</ispartof><rights>2022 The Authors. Molecular Nutrition & Food Research published by Wiley‐VCH GmbH</rights><rights>2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5027-3af8ba592ee5f96c4cb57042dca2d82da3f09350e770b76a0e88c6fda5b0ce3d3</citedby><cites>FETCH-LOGICAL-c5027-3af8ba592ee5f96c4cb57042dca2d82da3f09350e770b76a0e88c6fda5b0ce3d3</cites><orcidid>0000-0002-9158-283X ; 0000-0002-8856-0680 ; 0000-0003-3414-6983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.202200351$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.202200351$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36367234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:151195715$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Meuronen, Topi</creatorcontrib><creatorcontrib>Lankinen, Maria A.</creatorcontrib><creatorcontrib>Kolmert, Johan</creatorcontrib><creatorcontrib>de Mello, Vanessa Derenji</creatorcontrib><creatorcontrib>Sallinen, Taisa</creatorcontrib><creatorcontrib>Ågren, Jyrki</creatorcontrib><creatorcontrib>Virtanen, Kirsi A.</creatorcontrib><creatorcontrib>Laakso, Markku</creatorcontrib><creatorcontrib>Wheelock, Craig E.</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Schwab, Ursula</creatorcontrib><title>The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
The fatty acid composition of plasma lipids, which is associated with biomarkers and risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS). We investigated the interactions between dietary PUFAs and FADS1 rs174550 variant.
Methods and results
Participants (n = 118), homozygous for FADS1 rs174550 variant (TT and CC) followed a high alpha‐linolenic acid (ALA, 5 percent of energy (E‐%)) or a high linoleic acid (LA, 10 E‐%) diet during an 8‐week randomized controlled intervention. Fatty acid composition of plasma lipids and PUFA‐derived lipid mediators were quantified by gas and liquid chromatography mass spectrometry, respectively. The high‐LA diet increased the concentration of plasma LA, but not its lipid mediators. The concentration of plasma arachidonic acid decreased in carriers of CC and remained unchanged in the TT genotype. The high‐ALA diet increased the concentration of plasma ALA and its cytochrome P450‐derived epoxides and dihydroxys, and cyclooxygenase‐derived monohydroxys. Concentrations of plasma eicosapentaenoic acid and its mono‐ and dihydroxys increased only in TT genotype carriers.
Conclusions
These findings suggest the potential for genotype‐based recommendations for PUFA consumption, resulting in modulation of bioactive lipid mediators which can exert beneficial effects in maintaining health.
This study aimed to explore the differences in the plasma fatty acid and lipid mediator concentrations in response to dietary polyunsaturated fatty acids (PUFA) between carriers of the FADS1 rs174550 TT and CC genotypes. Plasma concentrations of long‐chain PUFAs and their derived bioactive lipid mediators changed in a genotype dependent manner in response to linoleic and alpha‐linolenic acid enriched diets.</description><subject>alpha-Linolenic Acid</subject><subject>Arachidonic acid</subject><subject>Biomarkers</subject><subject>Composition</subject><subject>Cytochrome</subject><subject>Cytochrome P450</subject><subject>Cytochromes P450</subject><subject>Desaturase</subject><subject>Diet</subject><subject>eicosanoid</subject><subject>Eicosapentaenoic acid</subject><subject>Epoxides</subject><subject>FADS</subject><subject>Fatty acid composition</subject><subject>Fatty Acid Desaturases - genetics</subject><subject>Fatty Acids</subject><subject>Fatty Acids, Unsaturated</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Health risks</subject><subject>Humans</subject><subject>Linoleic Acid</subject><subject>Linolenic acid</subject><subject>Lipids</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>octadecanoid</subject><subject>Plasma</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Polyunsaturated fatty acids</subject><subject>Prostaglandin endoperoxide synthase</subject><issn>1613-4125</issn><issn>1613-4133</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFkk1vEzEQhlcIREvhyhFZ4sJlgz_XuycUtaRFSgCV9mx57dnGZWMv6w1VbvwEjvw-fglONo0oF04ezzzvO_6YLHtJ8IRgTN-ufNNPKKYUYybIo-yYFITlnDD2-BBTcZQ9i_E2IYRy9jQ7YgUrJGX8OPt1tQQ0m559IaiPRHIhMDoHH4ZNB2gRrGscRDQkyP_-8ZMh7e0uKtDn69l0t527zlm0AOv0EHp0CbELPm5VAWl04W6WaNp2S51Uc-dDC94ZNDVJs1Xv6mP-Pn3mYIjPsyeNbiO82K8n2fXs_dXpRT7_dP7hdDrPjcBU5kw3Za1FRQFEUxWGm1pIzKk1mtqSWs0aXDGBQUpcy0JjKEtTNFaLGhtglp1k-egb76Bb16rr3Ur3GxW0U_vU1xSB4rwqeJX4dyOfKiuwBvzQ6_aB7GHFu6W6Cd9V-i4py6pMDm_2Dn34toY4qJWLBtpWewjrqKhkoix4yWRCX_-D3oZ179N7JErwkhIpaKImI2X6EGMPzeE0BG_bUrWdEnWYkiR49fcdDvj9WCSAj8Cda2HzHzu1-Di75IxL9gfIU8pZ</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Meuronen, Topi</creator><creator>Lankinen, Maria A.</creator><creator>Kolmert, Johan</creator><creator>de Mello, Vanessa Derenji</creator><creator>Sallinen, Taisa</creator><creator>Ågren, Jyrki</creator><creator>Virtanen, Kirsi A.</creator><creator>Laakso, Markku</creator><creator>Wheelock, Craig E.</creator><creator>Pihlajamäki, Jussi</creator><creator>Schwab, Ursula</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-9158-283X</orcidid><orcidid>https://orcid.org/0000-0002-8856-0680</orcidid><orcidid>https://orcid.org/0000-0003-3414-6983</orcidid></search><sort><creationdate>202212</creationdate><title>The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets</title><author>Meuronen, Topi ; Lankinen, Maria A. ; Kolmert, Johan ; de Mello, Vanessa Derenji ; Sallinen, Taisa ; Ågren, Jyrki ; Virtanen, Kirsi A. ; Laakso, Markku ; Wheelock, Craig E. ; Pihlajamäki, Jussi ; Schwab, Ursula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5027-3af8ba592ee5f96c4cb57042dca2d82da3f09350e770b76a0e88c6fda5b0ce3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>alpha-Linolenic Acid</topic><topic>Arachidonic acid</topic><topic>Biomarkers</topic><topic>Composition</topic><topic>Cytochrome</topic><topic>Cytochrome P450</topic><topic>Cytochromes P450</topic><topic>Desaturase</topic><topic>Diet</topic><topic>eicosanoid</topic><topic>Eicosapentaenoic acid</topic><topic>Epoxides</topic><topic>FADS</topic><topic>Fatty acid composition</topic><topic>Fatty Acid Desaturases - genetics</topic><topic>Fatty Acids</topic><topic>Fatty Acids, Unsaturated</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Health risks</topic><topic>Humans</topic><topic>Linoleic Acid</topic><topic>Linolenic acid</topic><topic>Lipids</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>octadecanoid</topic><topic>Plasma</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Polyunsaturated fatty acids</topic><topic>Prostaglandin endoperoxide synthase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meuronen, Topi</creatorcontrib><creatorcontrib>Lankinen, Maria A.</creatorcontrib><creatorcontrib>Kolmert, Johan</creatorcontrib><creatorcontrib>de Mello, Vanessa Derenji</creatorcontrib><creatorcontrib>Sallinen, Taisa</creatorcontrib><creatorcontrib>Ågren, Jyrki</creatorcontrib><creatorcontrib>Virtanen, Kirsi A.</creatorcontrib><creatorcontrib>Laakso, Markku</creatorcontrib><creatorcontrib>Wheelock, Craig E.</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Schwab, Ursula</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meuronen, Topi</au><au>Lankinen, Maria A.</au><au>Kolmert, Johan</au><au>de Mello, Vanessa Derenji</au><au>Sallinen, Taisa</au><au>Ågren, Jyrki</au><au>Virtanen, Kirsi A.</au><au>Laakso, Markku</au><au>Wheelock, Craig E.</au><au>Pihlajamäki, Jussi</au><au>Schwab, Ursula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2022-12</date><risdate>2022</risdate><volume>66</volume><issue>24</issue><spage>e2200351</spage><epage>n/a</epage><pages>e2200351-n/a</pages><issn>1613-4125</issn><issn>1613-4133</issn><eissn>1613-4133</eissn><abstract>Scope
The fatty acid composition of plasma lipids, which is associated with biomarkers and risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids (PUFAs) and variants of fatty acid desaturase (FADS). We investigated the interactions between dietary PUFAs and FADS1 rs174550 variant.
Methods and results
Participants (n = 118), homozygous for FADS1 rs174550 variant (TT and CC) followed a high alpha‐linolenic acid (ALA, 5 percent of energy (E‐%)) or a high linoleic acid (LA, 10 E‐%) diet during an 8‐week randomized controlled intervention. Fatty acid composition of plasma lipids and PUFA‐derived lipid mediators were quantified by gas and liquid chromatography mass spectrometry, respectively. The high‐LA diet increased the concentration of plasma LA, but not its lipid mediators. The concentration of plasma arachidonic acid decreased in carriers of CC and remained unchanged in the TT genotype. The high‐ALA diet increased the concentration of plasma ALA and its cytochrome P450‐derived epoxides and dihydroxys, and cyclooxygenase‐derived monohydroxys. Concentrations of plasma eicosapentaenoic acid and its mono‐ and dihydroxys increased only in TT genotype carriers.
Conclusions
These findings suggest the potential for genotype‐based recommendations for PUFA consumption, resulting in modulation of bioactive lipid mediators which can exert beneficial effects in maintaining health.
This study aimed to explore the differences in the plasma fatty acid and lipid mediator concentrations in response to dietary polyunsaturated fatty acids (PUFA) between carriers of the FADS1 rs174550 TT and CC genotypes. Plasma concentrations of long‐chain PUFAs and their derived bioactive lipid mediators changed in a genotype dependent manner in response to linoleic and alpha‐linolenic acid enriched diets.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36367234</pmid><doi>10.1002/mnfr.202200351</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9158-283X</orcidid><orcidid>https://orcid.org/0000-0002-8856-0680</orcidid><orcidid>https://orcid.org/0000-0003-3414-6983</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | alpha-Linolenic Acid Arachidonic acid Biomarkers Composition Cytochrome Cytochrome P450 Cytochromes P450 Desaturase Diet eicosanoid Eicosapentaenoic acid Epoxides FADS Fatty acid composition Fatty Acid Desaturases - genetics Fatty Acids Fatty Acids, Unsaturated Genotype Genotype & phenotype Genotypes Health risks Humans Linoleic Acid Linolenic acid Lipids Liquid chromatography Mass spectrometry Mass spectroscopy octadecanoid Plasma Polymorphism, Single Nucleotide Polyunsaturated fatty acids Prostaglandin endoperoxide synthase |
| title | The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets |
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