A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19
Background Several studies have investigated associations between ABO blood group and risk of COVID‐19, with inconsistent results. Objective To study associations between ABO blood group and risk of different stages of COVID‐19. Methods The study was based on nationwide registers encompassing all bl...
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| Veröffentlicht in: | Journal of internal medicine 2023-03, Vol.293 (3), p.398-402 |
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| creator | Dahlén, Torsten Li, Huiqi Nyberg, Fredrik Edgren, Gustaf |
| description | Background
Several studies have investigated associations between ABO blood group and risk of COVID‐19, with inconsistent results.
Objective
To study associations between ABO blood group and risk of different stages of COVID‐19.
Methods
The study was based on nationwide registers encompassing all blood‐grouped persons in Sweden, and all of their COVID‐19‐related outcomes. Associations between ABO blood group and COVID‐19 outcomes were estimated using Poisson regression models. Analyses were conducted overall and stratified by vaccination status.
Results
A total of 4,986,878 individuals were included. The incidence rate ratios of testing positive for COVID‐19 were 1.08 (95% confidence interval [CI], 1.07–1.08), 1.06 (95% CI, 1.05–1.07), and 1.01 (95% CI, 1.00–1.01) for blood groups A, AB, and B, respectively, as compared to O. Similar associations were seen for risk of hospital admissions, intensive care unit admissions, and risk of death. For most outcomes, associations with ABO blood group were much attenuated or even reversed in vaccinated individuals.
Conclusions
Individuals with blood groups A, AB, and B are at increased risk of contracting COVID‐19 as well as developing more severe forms of the disease. |
| doi_str_mv | 10.1111/joim.13588 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_449619</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2771499901</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5248-96d3f41cacb81100bf7214e4791e668b5b9405f0206dfa70bdcd5d133a4d62af3</originalsourceid><addsrcrecordid>eNp9ks2O0zAQxy0EYkvhwgMgS1wQIos_Yie-IJXyVbSoF-BqOfGkTTeNg51s1RuPwDPyJDibsmI5rA_2aPybv0eeP0JPKTmncb3euXp_TrnI83toRrkUCcuUvI9mRIk0kTkjZ-hRCDtCKCeSPERnXPKMKSFmyC9w57qhMX3t2t8_fxUmgH2FPfTehQ7Kvr4CXLqt8z0O_WCP2FW43wI2Ibiyvi7DBfQHgBYv3q5x0Thn8ca7ocOmtdjX4XKsWa6_r97FB6h6jB5Upgnw5HTO0bcP778uPyUX64-r5eIiKQVL80RJy6uUlqYsckoJKaqM0RTSTFGQMi9EoVIiKsKItJXJSGFLKyzl3KRWMlPxOUom3XCAbih05-u98UftTK1PqcsYgU5TJam6k98MnY6pzTDynFHGaeTfTHyE92BLaHtvmltlt2_aeqs37kqrPMuynESBFycB734MEHq9r0MJTWNacEPQLItzIkLGfY6e_4fu3ODb-H2RymiqlCJjRy8nqozDCx6qm2Yo0aNV9GgVfW2VCD_7t_0b9K83IkAn4FA3cLxDSn9er75Mon8AQtHNIQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2771499901</pqid></control><display><type>article</type><title>A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SWEPUB Freely available online</source><creator>Dahlén, Torsten ; Li, Huiqi ; Nyberg, Fredrik ; Edgren, Gustaf</creator><creatorcontrib>Dahlén, Torsten ; Li, Huiqi ; Nyberg, Fredrik ; Edgren, Gustaf</creatorcontrib><description>Background
Several studies have investigated associations between ABO blood group and risk of COVID‐19, with inconsistent results.
Objective
To study associations between ABO blood group and risk of different stages of COVID‐19.
Methods
The study was based on nationwide registers encompassing all blood‐grouped persons in Sweden, and all of their COVID‐19‐related outcomes. Associations between ABO blood group and COVID‐19 outcomes were estimated using Poisson regression models. Analyses were conducted overall and stratified by vaccination status.
Results
A total of 4,986,878 individuals were included. The incidence rate ratios of testing positive for COVID‐19 were 1.08 (95% confidence interval [CI], 1.07–1.08), 1.06 (95% CI, 1.05–1.07), and 1.01 (95% CI, 1.00–1.01) for blood groups A, AB, and B, respectively, as compared to O. Similar associations were seen for risk of hospital admissions, intensive care unit admissions, and risk of death. For most outcomes, associations with ABO blood group were much attenuated or even reversed in vaccinated individuals.
Conclusions
Individuals with blood groups A, AB, and B are at increased risk of contracting COVID‐19 as well as developing more severe forms of the disease.</description><identifier>ISSN: 0954-6820</identifier><identifier>ISSN: 1365-2796</identifier><identifier>EISSN: 1365-2796</identifier><identifier>DOI: 10.1111/joim.13588</identifier><identifier>PMID: 36372955</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>ABO blood group ; ABO Blood-Group System ; ABO system ; Blood groups ; Brief Report ; cause of death ; Cohort analysis ; Confidence intervals ; COVID-19 ; COVID-19 - epidemiology ; Folkhälsovetenskap, global hälsa och socialmedicin ; Humans ; Incidence ; Infectious Medicine ; Infektionsmedicin ; intensive care ; Population studies ; Population-based studies ; Public Health, Global Health and Social Medicine ; Regression analysis ; Regression models ; Retrospective Studies ; Risk ; Statistical analysis ; Sweden - epidemiology ; Vaccination</subject><ispartof>Journal of internal medicine, 2023-03, Vol.293 (3), p.398-402</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.</rights><rights>2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5248-96d3f41cacb81100bf7214e4791e668b5b9405f0206dfa70bdcd5d133a4d62af3</citedby><cites>FETCH-LOGICAL-c5248-96d3f41cacb81100bf7214e4791e668b5b9405f0206dfa70bdcd5d133a4d62af3</cites><orcidid>0000-0002-2198-4745 ; 0000-0002-3856-7227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjoim.13588$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjoim.13588$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36372955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/321231$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:151356574$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Dahlén, Torsten</creatorcontrib><creatorcontrib>Li, Huiqi</creatorcontrib><creatorcontrib>Nyberg, Fredrik</creatorcontrib><creatorcontrib>Edgren, Gustaf</creatorcontrib><title>A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19</title><title>Journal of internal medicine</title><addtitle>J Intern Med</addtitle><description>Background
Several studies have investigated associations between ABO blood group and risk of COVID‐19, with inconsistent results.
Objective
To study associations between ABO blood group and risk of different stages of COVID‐19.
Methods
The study was based on nationwide registers encompassing all blood‐grouped persons in Sweden, and all of their COVID‐19‐related outcomes. Associations between ABO blood group and COVID‐19 outcomes were estimated using Poisson regression models. Analyses were conducted overall and stratified by vaccination status.
Results
A total of 4,986,878 individuals were included. The incidence rate ratios of testing positive for COVID‐19 were 1.08 (95% confidence interval [CI], 1.07–1.08), 1.06 (95% CI, 1.05–1.07), and 1.01 (95% CI, 1.00–1.01) for blood groups A, AB, and B, respectively, as compared to O. Similar associations were seen for risk of hospital admissions, intensive care unit admissions, and risk of death. For most outcomes, associations with ABO blood group were much attenuated or even reversed in vaccinated individuals.
Conclusions
Individuals with blood groups A, AB, and B are at increased risk of contracting COVID‐19 as well as developing more severe forms of the disease.</description><subject>ABO blood group</subject><subject>ABO Blood-Group System</subject><subject>ABO system</subject><subject>Blood groups</subject><subject>Brief Report</subject><subject>cause of death</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>COVID-19</subject><subject>COVID-19 - epidemiology</subject><subject>Folkhälsovetenskap, global hälsa och socialmedicin</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious Medicine</subject><subject>Infektionsmedicin</subject><subject>intensive care</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Public Health, Global Health and Social Medicine</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Statistical analysis</subject><subject>Sweden - epidemiology</subject><subject>Vaccination</subject><issn>0954-6820</issn><issn>1365-2796</issn><issn>1365-2796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9ks2O0zAQxy0EYkvhwgMgS1wQIos_Yie-IJXyVbSoF-BqOfGkTTeNg51s1RuPwDPyJDibsmI5rA_2aPybv0eeP0JPKTmncb3euXp_TrnI83toRrkUCcuUvI9mRIk0kTkjZ-hRCDtCKCeSPERnXPKMKSFmyC9w57qhMX3t2t8_fxUmgH2FPfTehQ7Kvr4CXLqt8z0O_WCP2FW43wI2Ibiyvi7DBfQHgBYv3q5x0Thn8ca7ocOmtdjX4XKsWa6_r97FB6h6jB5Upgnw5HTO0bcP778uPyUX64-r5eIiKQVL80RJy6uUlqYsckoJKaqM0RTSTFGQMi9EoVIiKsKItJXJSGFLKyzl3KRWMlPxOUom3XCAbih05-u98UftTK1PqcsYgU5TJam6k98MnY6pzTDynFHGaeTfTHyE92BLaHtvmltlt2_aeqs37kqrPMuynESBFycB734MEHq9r0MJTWNacEPQLItzIkLGfY6e_4fu3ODb-H2RymiqlCJjRy8nqozDCx6qm2Yo0aNV9GgVfW2VCD_7t_0b9K83IkAn4FA3cLxDSn9er75Mon8AQtHNIQ</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Dahlén, Torsten</creator><creator>Li, Huiqi</creator><creator>Nyberg, Fredrik</creator><creator>Edgren, Gustaf</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-2198-4745</orcidid><orcidid>https://orcid.org/0000-0002-3856-7227</orcidid></search><sort><creationdate>202303</creationdate><title>A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19</title><author>Dahlén, Torsten ; Li, Huiqi ; Nyberg, Fredrik ; Edgren, Gustaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5248-96d3f41cacb81100bf7214e4791e668b5b9405f0206dfa70bdcd5d133a4d62af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ABO blood group</topic><topic>ABO Blood-Group System</topic><topic>ABO system</topic><topic>Blood groups</topic><topic>Brief Report</topic><topic>cause of death</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>COVID-19</topic><topic>COVID-19 - epidemiology</topic><topic>Folkhälsovetenskap, global hälsa och socialmedicin</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious Medicine</topic><topic>Infektionsmedicin</topic><topic>intensive care</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Public Health, Global Health and Social Medicine</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Statistical analysis</topic><topic>Sweden - epidemiology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dahlén, Torsten</creatorcontrib><creatorcontrib>Li, Huiqi</creatorcontrib><creatorcontrib>Nyberg, Fredrik</creatorcontrib><creatorcontrib>Edgren, Gustaf</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dahlén, Torsten</au><au>Li, Huiqi</au><au>Nyberg, Fredrik</au><au>Edgren, Gustaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19</atitle><jtitle>Journal of internal medicine</jtitle><addtitle>J Intern Med</addtitle><date>2023-03</date><risdate>2023</risdate><volume>293</volume><issue>3</issue><spage>398</spage><epage>402</epage><pages>398-402</pages><issn>0954-6820</issn><issn>1365-2796</issn><eissn>1365-2796</eissn><abstract>Background
Several studies have investigated associations between ABO blood group and risk of COVID‐19, with inconsistent results.
Objective
To study associations between ABO blood group and risk of different stages of COVID‐19.
Methods
The study was based on nationwide registers encompassing all blood‐grouped persons in Sweden, and all of their COVID‐19‐related outcomes. Associations between ABO blood group and COVID‐19 outcomes were estimated using Poisson regression models. Analyses were conducted overall and stratified by vaccination status.
Results
A total of 4,986,878 individuals were included. The incidence rate ratios of testing positive for COVID‐19 were 1.08 (95% confidence interval [CI], 1.07–1.08), 1.06 (95% CI, 1.05–1.07), and 1.01 (95% CI, 1.00–1.01) for blood groups A, AB, and B, respectively, as compared to O. Similar associations were seen for risk of hospital admissions, intensive care unit admissions, and risk of death. For most outcomes, associations with ABO blood group were much attenuated or even reversed in vaccinated individuals.
Conclusions
Individuals with blood groups A, AB, and B are at increased risk of contracting COVID‐19 as well as developing more severe forms of the disease.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>36372955</pmid><doi>10.1111/joim.13588</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2198-4745</orcidid><orcidid>https://orcid.org/0000-0002-3856-7227</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | ABO blood group ABO Blood-Group System ABO system Blood groups Brief Report cause of death Cohort analysis Confidence intervals COVID-19 COVID-19 - epidemiology Folkhälsovetenskap, global hälsa och socialmedicin Humans Incidence Infectious Medicine Infektionsmedicin intensive care Population studies Population-based studies Public Health, Global Health and Social Medicine Regression analysis Regression models Retrospective Studies Risk Statistical analysis Sweden - epidemiology Vaccination |
| title | A population‐based, retrospective cohort study of the association between ABO blood group and risk of COVID‐19 |
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