Vaccination induces HIV broadly neutralizing antibody precursors in humans
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine-primi...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2022-12, Vol.378 (6623), p.eadd6502-eadd6502 |
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| creator | Leggat, David J Cohen, Kristen W Willis, Jordan R Fulp, William J deCamp, Allan C Kalyuzhniy, Oleksandr Cottrell, Christopher A Menis, Sergey Finak, Greg Ballweber-Fleming, Lamar Srikanth, Abhinaya Plyler, Jason R Schiffner, Torben Liguori, Alessia Rahaman, Farhad Lombardo, Angela Philiponis, Vincent Whaley, Rachael E Seese, Aaron Brand, Joshua Ruppel, Alexis M Hoyland, Wesley Yates, Nicole L Williams, LaTonya D Greene, Kelli Gao, Hongmei Mahoney, Celia R Corcoran, Martin M Cagigi, Alberto Taylor, Alison Brown, David M Ambrozak, David R Sincomb, Troy Hu, Xiaozhen Tingle, Ryan Georgeson, Erik Eskandarzadeh, Saman Alavi, Nushin Lu, Danny Mullen, Tina-Marie Kubitz, Michael Groschel, Bettina Maenza, Janine Kolokythas, Orpheus Khati, Nadia Bethony, Jeffrey Crotty, Shane Roederer, Mario Karlsson Hedestam, Gunilla B Tomaras, Georgia D Montefiori, David Diemert, David Koup, Richard A Laufer, Dagna S McElrath, M Juliana McDermott, Adrian B Schief, William R |
| description | Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine-priming candidate eOD-GT8 60mer adjuvanted with AS01
had a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens. |
| doi_str_mv | 10.1126/science.add6502 |
| format | Article |
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had a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 1095-9203</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.add6502</identifier><identifier>PMID: 36454825</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Adjuvants, Immunologic ; Adult ; Affinity ; AIDS Vaccines - immunology ; Amino acids ; Antibodies ; Antigens ; B-cell receptor ; B-Lymphocytes - immunology ; Binding ; Blood ; Broadly Neutralizing Antibodies - genetics ; Broadly Neutralizing Antibodies - immunology ; Chains ; Clinical trials ; Complementarity ; Complementarity-determining region 3 ; Epitopes ; Female ; Germ Cells - immunology ; Glycoproteins ; Hemopoiesis ; Hepatitis C ; HIV ; HIV Antibodies - genetics ; HIV Antibodies - immunology ; HIV Infections - prevention & control ; Human immunodeficiency virus ; Humans ; IgG antibody ; Immune system ; Immunity ; Immunoglobulin G ; Immunoglobulin Heavy Chains - genetics ; Immunoglobulin Heavy Chains - immunology ; Immunoglobulin Light Chains - genetics ; Immunoglobulin Light Chains - immunology ; Immunological memory ; Influenza ; Lymph nodes ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Male ; Maturation ; Membrane glycoproteins ; Memory cells ; Monoclonal antibodies ; Mutation ; Nanoparticles ; Neutralizing ; Pathogens ; Precursors ; Priming ; Public health ; Safety ; Somatic hypermutation ; Statistical analysis ; Vaccination ; Vaccines</subject><ispartof>Science (American Association for the Advancement of Science), 2022-12, Vol.378 (6623), p.eadd6502-eadd6502</ispartof><rights>Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-45f9ba8eef336cb88a1ba842e91918cc016edbf379e24b6f84c9183ce5e3d9cf3</citedby><cites>FETCH-LOGICAL-c460t-45f9ba8eef336cb88a1ba842e91918cc016edbf379e24b6f84c9183ce5e3d9cf3</cites><orcidid>0000-0002-8901-9941 ; 0000-0002-4578-4860 ; 0000-0003-0182-133X ; 0000-0003-3890-0533 ; 0000-0003-0856-6319 ; 0000-0002-2319-8481 ; 0000-0002-6180-5545 ; 0000-0002-2468-8589 ; 0000-0003-1404-4322 ; 0000-0001-6707-9962 ; 0000-0001-6150-8084 ; 0000-0002-6484-6262 ; 0000-0001-7448-7040 ; 0000-0003-4463-8316 ; 0000-0003-4556-649X ; 0000-0003-4069-4580 ; 0000-0002-8606-574X ; 0000-0003-3848-6280 ; 0000-0001-7255-9047 ; 0000-0003-2874-7010 ; 0000-0002-3992-4193 ; 0000-0002-2340-3377 ; 0000-0001-8064-8533 ; 0000-0002-3567-9514 ; 0000-0002-3090-7282 ; 0000-0003-3127-5448 ; 0000-0002-3364-3083 ; 0000-0002-5273-1951 ; 0000-0003-4341-9090 ; 0000-0002-0135-5263 ; 0000-0002-0671-0770 ; 0000-0003-2276-7117 ; 0000-0001-5411-7333 ; 0000-0002-5877-6229 ; 0000-0002-0747-0625 ; 0000-0002-2789-0512 ; 0000-0003-4019-7170 ; 0000-0001-5137-4625 ; 0000-0002-1120-0150 ; 0000-0001-8076-1931 ; 0000-0003-2678-1311 ; 0000-0001-6772-8870 ; 0000-0003-0616-9117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,2871,2872,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36454825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:151565566$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Leggat, David J</creatorcontrib><creatorcontrib>Cohen, Kristen W</creatorcontrib><creatorcontrib>Willis, Jordan R</creatorcontrib><creatorcontrib>Fulp, William J</creatorcontrib><creatorcontrib>deCamp, Allan C</creatorcontrib><creatorcontrib>Kalyuzhniy, Oleksandr</creatorcontrib><creatorcontrib>Cottrell, Christopher A</creatorcontrib><creatorcontrib>Menis, Sergey</creatorcontrib><creatorcontrib>Finak, Greg</creatorcontrib><creatorcontrib>Ballweber-Fleming, Lamar</creatorcontrib><creatorcontrib>Srikanth, Abhinaya</creatorcontrib><creatorcontrib>Plyler, Jason R</creatorcontrib><creatorcontrib>Schiffner, Torben</creatorcontrib><creatorcontrib>Liguori, Alessia</creatorcontrib><creatorcontrib>Rahaman, Farhad</creatorcontrib><creatorcontrib>Lombardo, Angela</creatorcontrib><creatorcontrib>Philiponis, Vincent</creatorcontrib><creatorcontrib>Whaley, Rachael E</creatorcontrib><creatorcontrib>Seese, Aaron</creatorcontrib><creatorcontrib>Brand, Joshua</creatorcontrib><creatorcontrib>Ruppel, Alexis M</creatorcontrib><creatorcontrib>Hoyland, Wesley</creatorcontrib><creatorcontrib>Yates, Nicole L</creatorcontrib><creatorcontrib>Williams, LaTonya D</creatorcontrib><creatorcontrib>Greene, Kelli</creatorcontrib><creatorcontrib>Gao, Hongmei</creatorcontrib><creatorcontrib>Mahoney, Celia R</creatorcontrib><creatorcontrib>Corcoran, Martin M</creatorcontrib><creatorcontrib>Cagigi, Alberto</creatorcontrib><creatorcontrib>Taylor, Alison</creatorcontrib><creatorcontrib>Brown, David M</creatorcontrib><creatorcontrib>Ambrozak, David R</creatorcontrib><creatorcontrib>Sincomb, Troy</creatorcontrib><creatorcontrib>Hu, Xiaozhen</creatorcontrib><creatorcontrib>Tingle, Ryan</creatorcontrib><creatorcontrib>Georgeson, Erik</creatorcontrib><creatorcontrib>Eskandarzadeh, Saman</creatorcontrib><creatorcontrib>Alavi, Nushin</creatorcontrib><creatorcontrib>Lu, Danny</creatorcontrib><creatorcontrib>Mullen, Tina-Marie</creatorcontrib><creatorcontrib>Kubitz, Michael</creatorcontrib><creatorcontrib>Groschel, Bettina</creatorcontrib><creatorcontrib>Maenza, Janine</creatorcontrib><creatorcontrib>Kolokythas, Orpheus</creatorcontrib><creatorcontrib>Khati, Nadia</creatorcontrib><creatorcontrib>Bethony, Jeffrey</creatorcontrib><creatorcontrib>Crotty, Shane</creatorcontrib><creatorcontrib>Roederer, Mario</creatorcontrib><creatorcontrib>Karlsson Hedestam, Gunilla B</creatorcontrib><creatorcontrib>Tomaras, Georgia D</creatorcontrib><creatorcontrib>Montefiori, David</creatorcontrib><creatorcontrib>Diemert, David</creatorcontrib><creatorcontrib>Koup, Richard A</creatorcontrib><creatorcontrib>Laufer, Dagna S</creatorcontrib><creatorcontrib>McElrath, M Juliana</creatorcontrib><creatorcontrib>McDermott, Adrian B</creatorcontrib><creatorcontrib>Schief, William R</creatorcontrib><title>Vaccination induces HIV broadly neutralizing antibody precursors in humans</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine-priming candidate eOD-GT8 60mer adjuvanted with AS01
had a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.</description><subject>Adjuvants, Immunologic</subject><subject>Adult</subject><subject>Affinity</subject><subject>AIDS Vaccines - immunology</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>B-cell receptor</subject><subject>B-Lymphocytes - immunology</subject><subject>Binding</subject><subject>Blood</subject><subject>Broadly Neutralizing Antibodies - genetics</subject><subject>Broadly Neutralizing Antibodies - immunology</subject><subject>Chains</subject><subject>Clinical trials</subject><subject>Complementarity</subject><subject>Complementarity-determining region 3</subject><subject>Epitopes</subject><subject>Female</subject><subject>Germ Cells - immunology</subject><subject>Glycoproteins</subject><subject>Hemopoiesis</subject><subject>Hepatitis C</subject><subject>HIV</subject><subject>HIV Antibodies - genetics</subject><subject>HIV Antibodies - immunology</subject><subject>HIV Infections - prevention & control</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin Heavy Chains - genetics</subject><subject>Immunoglobulin Heavy Chains - immunology</subject><subject>Immunoglobulin Light Chains - genetics</subject><subject>Immunoglobulin Light Chains - immunology</subject><subject>Immunological memory</subject><subject>Influenza</subject><subject>Lymph nodes</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Maturation</subject><subject>Membrane glycoproteins</subject><subject>Memory cells</subject><subject>Monoclonal antibodies</subject><subject>Mutation</subject><subject>Nanoparticles</subject><subject>Neutralizing</subject><subject>Pathogens</subject><subject>Precursors</subject><subject>Priming</subject><subject>Public health</subject><subject>Safety</subject><subject>Somatic hypermutation</subject><subject>Statistical analysis</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>0036-8075</issn><issn>1095-9203</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNpdkc1PGzEQxa2KqoS0Z25oJS69LPg76xNCqECqSL20uVpe72xi2NjB3qVK_3ocZYuanmzP-72RZx5C5wRfEULldbIOvIUr0zRSYPoBTQhWolQUsxM0wZjJssIzcYrOUnrCOGuKfUKnTHLBKyom6PvSWOu86V3whfPNYCEVj_NlUcdgmm5XeBj6aDr3x_lVYXzv6tDsim0EO8QUYsqmYj1sjE-f0cfWdAm-jOcU_br_9vPusVz8eJjf3S5KyyXuSy5aVZsKoGVM2rqqDMlPTkERRSprMZHQ1C2bKaC8lm3Fba4zCwJYo2zLpqg89E2_YTvUehvdxsSdDsbpsfScb6A5V1TMMn9z4LOygcaC3w90ZDtWvFvrVXjVhBDMaN7YFH0dO8TwMkDq9cYlC11nPIQhaTrjkikpqMzo5X_oUxiiz_vYU4IQTinL1PWBsjGkFKF9_w3Beh-sHoPVY7DZcfHvEO_83yTZG8muo5Q</recordid><startdate>20221202</startdate><enddate>20221202</enddate><creator>Leggat, David J</creator><creator>Cohen, Kristen W</creator><creator>Willis, Jordan R</creator><creator>Fulp, William 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induces HIV broadly neutralizing antibody precursors in humans</title><author>Leggat, David J ; Cohen, Kristen W ; Willis, Jordan R ; Fulp, William J ; deCamp, Allan C ; Kalyuzhniy, Oleksandr ; Cottrell, Christopher A ; Menis, Sergey ; Finak, Greg ; Ballweber-Fleming, Lamar ; Srikanth, Abhinaya ; Plyler, Jason R ; Schiffner, Torben ; Liguori, Alessia ; Rahaman, Farhad ; Lombardo, Angela ; Philiponis, Vincent ; Whaley, Rachael E ; Seese, Aaron ; Brand, Joshua ; Ruppel, Alexis M ; Hoyland, Wesley ; Yates, Nicole L ; Williams, LaTonya D ; Greene, Kelli ; Gao, Hongmei ; Mahoney, Celia R ; Corcoran, Martin M ; Cagigi, Alberto ; Taylor, Alison ; Brown, David M ; Ambrozak, David R ; Sincomb, Troy ; Hu, Xiaozhen ; Tingle, Ryan ; Georgeson, Erik ; Eskandarzadeh, Saman ; Alavi, Nushin ; Lu, Danny ; Mullen, Tina-Marie ; Kubitz, Michael ; Groschel, Bettina ; Maenza, Janine ; Kolokythas, Orpheus ; Khati, Nadia ; Bethony, Jeffrey ; Crotty, Shane ; Roederer, Mario ; Karlsson Hedestam, Gunilla B ; Tomaras, Georgia D ; Montefiori, David ; Diemert, David ; Koup, Richard A ; Laufer, Dagna S ; McElrath, M Juliana ; McDermott, Adrian B ; Schief, William R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-45f9ba8eef336cb88a1ba842e91918cc016edbf379e24b6f84c9183ce5e3d9cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adjuvants, Immunologic</topic><topic>Adult</topic><topic>Affinity</topic><topic>AIDS Vaccines - immunology</topic><topic>Amino acids</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>B-cell receptor</topic><topic>B-Lymphocytes - immunology</topic><topic>Binding</topic><topic>Blood</topic><topic>Broadly Neutralizing Antibodies - genetics</topic><topic>Broadly Neutralizing Antibodies - immunology</topic><topic>Chains</topic><topic>Clinical trials</topic><topic>Complementarity</topic><topic>Complementarity-determining region 3</topic><topic>Epitopes</topic><topic>Female</topic><topic>Germ Cells - immunology</topic><topic>Glycoproteins</topic><topic>Hemopoiesis</topic><topic>Hepatitis C</topic><topic>HIV</topic><topic>HIV Antibodies - genetics</topic><topic>HIV Antibodies - immunology</topic><topic>HIV Infections - prevention & control</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>IgG antibody</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin Heavy Chains - genetics</topic><topic>Immunoglobulin Heavy Chains - immunology</topic><topic>Immunoglobulin Light Chains - genetics</topic><topic>Immunoglobulin Light Chains - immunology</topic><topic>Immunological memory</topic><topic>Influenza</topic><topic>Lymph nodes</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Maturation</topic><topic>Membrane glycoproteins</topic><topic>Memory cells</topic><topic>Monoclonal antibodies</topic><topic>Mutation</topic><topic>Nanoparticles</topic><topic>Neutralizing</topic><topic>Pathogens</topic><topic>Precursors</topic><topic>Priming</topic><topic>Public health</topic><topic>Safety</topic><topic>Somatic hypermutation</topic><topic>Statistical analysis</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leggat, David J</creatorcontrib><creatorcontrib>Cohen, Kristen W</creatorcontrib><creatorcontrib>Willis, Jordan R</creatorcontrib><creatorcontrib>Fulp, William J</creatorcontrib><creatorcontrib>deCamp, Allan C</creatorcontrib><creatorcontrib>Kalyuzhniy, Oleksandr</creatorcontrib><creatorcontrib>Cottrell, Christopher A</creatorcontrib><creatorcontrib>Menis, Sergey</creatorcontrib><creatorcontrib>Finak, Greg</creatorcontrib><creatorcontrib>Ballweber-Fleming, Lamar</creatorcontrib><creatorcontrib>Srikanth, 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text</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leggat, David J</au><au>Cohen, Kristen W</au><au>Willis, Jordan R</au><au>Fulp, William J</au><au>deCamp, Allan C</au><au>Kalyuzhniy, Oleksandr</au><au>Cottrell, Christopher A</au><au>Menis, Sergey</au><au>Finak, Greg</au><au>Ballweber-Fleming, Lamar</au><au>Srikanth, Abhinaya</au><au>Plyler, Jason R</au><au>Schiffner, Torben</au><au>Liguori, Alessia</au><au>Rahaman, Farhad</au><au>Lombardo, Angela</au><au>Philiponis, Vincent</au><au>Whaley, Rachael E</au><au>Seese, Aaron</au><au>Brand, Joshua</au><au>Ruppel, Alexis M</au><au>Hoyland, Wesley</au><au>Yates, Nicole L</au><au>Williams, LaTonya D</au><au>Greene, Kelli</au><au>Gao, Hongmei</au><au>Mahoney, Celia R</au><au>Corcoran, Martin M</au><au>Cagigi, Alberto</au><au>Taylor, Alison</au><au>Brown, David M</au><au>Ambrozak, David R</au><au>Sincomb, Troy</au><au>Hu, Xiaozhen</au><au>Tingle, Ryan</au><au>Georgeson, Erik</au><au>Eskandarzadeh, Saman</au><au>Alavi, Nushin</au><au>Lu, Danny</au><au>Mullen, Tina-Marie</au><au>Kubitz, Michael</au><au>Groschel, Bettina</au><au>Maenza, Janine</au><au>Kolokythas, Orpheus</au><au>Khati, Nadia</au><au>Bethony, Jeffrey</au><au>Crotty, Shane</au><au>Roederer, Mario</au><au>Karlsson Hedestam, Gunilla B</au><au>Tomaras, Georgia D</au><au>Montefiori, David</au><au>Diemert, David</au><au>Koup, Richard A</au><au>Laufer, Dagna S</au><au>McElrath, M Juliana</au><au>McDermott, Adrian B</au><au>Schief, William R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccination induces HIV broadly neutralizing antibody precursors in humans</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2022-12-02</date><risdate>2022</risdate><volume>378</volume><issue>6623</issue><spage>eadd6502</spage><epage>eadd6502</epage><pages>eadd6502-eadd6502</pages><issn>0036-8075</issn><issn>1095-9203</issn><eissn>1095-9203</eissn><abstract>Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine-priming candidate eOD-GT8 60mer adjuvanted with AS01
had a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>36454825</pmid><doi>10.1126/science.add6502</doi><orcidid>https://orcid.org/0000-0002-8901-9941</orcidid><orcidid>https://orcid.org/0000-0002-4578-4860</orcidid><orcidid>https://orcid.org/0000-0003-0182-133X</orcidid><orcidid>https://orcid.org/0000-0003-3890-0533</orcidid><orcidid>https://orcid.org/0000-0003-0856-6319</orcidid><orcidid>https://orcid.org/0000-0002-2319-8481</orcidid><orcidid>https://orcid.org/0000-0002-6180-5545</orcidid><orcidid>https://orcid.org/0000-0002-2468-8589</orcidid><orcidid>https://orcid.org/0000-0003-1404-4322</orcidid><orcidid>https://orcid.org/0000-0001-6707-9962</orcidid><orcidid>https://orcid.org/0000-0001-6150-8084</orcidid><orcidid>https://orcid.org/0000-0002-6484-6262</orcidid><orcidid>https://orcid.org/0000-0001-7448-7040</orcidid><orcidid>https://orcid.org/0000-0003-4463-8316</orcidid><orcidid>https://orcid.org/0000-0003-4556-649X</orcidid><orcidid>https://orcid.org/0000-0003-4069-4580</orcidid><orcidid>https://orcid.org/0000-0002-8606-574X</orcidid><orcidid>https://orcid.org/0000-0003-3848-6280</orcidid><orcidid>https://orcid.org/0000-0001-7255-9047</orcidid><orcidid>https://orcid.org/0000-0003-2874-7010</orcidid><orcidid>https://orcid.org/0000-0002-3992-4193</orcidid><orcidid>https://orcid.org/0000-0002-2340-3377</orcidid><orcidid>https://orcid.org/0000-0001-8064-8533</orcidid><orcidid>https://orcid.org/0000-0002-3567-9514</orcidid><orcidid>https://orcid.org/0000-0002-3090-7282</orcidid><orcidid>https://orcid.org/0000-0003-3127-5448</orcidid><orcidid>https://orcid.org/0000-0002-3364-3083</orcidid><orcidid>https://orcid.org/0000-0002-5273-1951</orcidid><orcidid>https://orcid.org/0000-0003-4341-9090</orcidid><orcidid>https://orcid.org/0000-0002-0135-5263</orcidid><orcidid>https://orcid.org/0000-0002-0671-0770</orcidid><orcidid>https://orcid.org/0000-0003-2276-7117</orcidid><orcidid>https://orcid.org/0000-0001-5411-7333</orcidid><orcidid>https://orcid.org/0000-0002-5877-6229</orcidid><orcidid>https://orcid.org/0000-0002-0747-0625</orcidid><orcidid>https://orcid.org/0000-0002-2789-0512</orcidid><orcidid>https://orcid.org/0000-0003-4019-7170</orcidid><orcidid>https://orcid.org/0000-0001-5137-4625</orcidid><orcidid>https://orcid.org/0000-0002-1120-0150</orcidid><orcidid>https://orcid.org/0000-0001-8076-1931</orcidid><orcidid>https://orcid.org/0000-0003-2678-1311</orcidid><orcidid>https://orcid.org/0000-0001-6772-8870</orcidid><orcidid>https://orcid.org/0000-0003-0616-9117</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2022-12, Vol.378 (6623), p.eadd6502-eadd6502 |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_449257 |
| source | American Association for the Advancement of Science; MEDLINE; SWEPUB Freely available online |
| subjects | Adjuvants, Immunologic Adult Affinity AIDS Vaccines - immunology Amino acids Antibodies Antigens B-cell receptor B-Lymphocytes - immunology Binding Blood Broadly Neutralizing Antibodies - genetics Broadly Neutralizing Antibodies - immunology Chains Clinical trials Complementarity Complementarity-determining region 3 Epitopes Female Germ Cells - immunology Glycoproteins Hemopoiesis Hepatitis C HIV HIV Antibodies - genetics HIV Antibodies - immunology HIV Infections - prevention & control Human immunodeficiency virus Humans IgG antibody Immune system Immunity Immunoglobulin G Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology Immunoglobulin Light Chains - genetics Immunoglobulin Light Chains - immunology Immunological memory Influenza Lymph nodes Lymphocytes Lymphocytes B Lymphocytes T Male Maturation Membrane glycoproteins Memory cells Monoclonal antibodies Mutation Nanoparticles Neutralizing Pathogens Precursors Priming Public health Safety Somatic hypermutation Statistical analysis Vaccination Vaccines |
| title | Vaccination induces HIV broadly neutralizing antibody precursors in humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T12%3A24%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vaccination%20induces%20HIV%20broadly%20neutralizing%20antibody%20precursors%20in%20humans&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Leggat,%20David%20J&rft.date=2022-12-02&rft.volume=378&rft.issue=6623&rft.spage=eadd6502&rft.epage=eadd6502&rft.pages=eadd6502-eadd6502&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.add6502&rft_dat=%3Cproquest_swepu%3E2745114223%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2745114223&rft_id=info:pmid/36454825&rfr_iscdi=true |