In silico model of atherosclerosis with individual patient calibration to enable precision medicine for cardiovascular disease

Guidance for preventing myocardial infarction and ischemic stroke by tailoring treatment for individual patients with atherosclerosis is an unmet need. Such development may be possible with computational modeling. Given the multifactorial biology of atherosclerosis, modeling must be based on complet...

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Veröffentlicht in:	Computers in biology and medicine 2023-01, Vol.152, p.106364, Article 106364
Hauptverfasser:	Buckler, Andrew J., Marlevi, David, Skenteris, Nikolaos T., Lengquist, Mariette, Kronqvist, Malin, Matic, Ljubica, Hedin, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis Atherosclerosis Atherosclerosis - drug therapy Biobanks Biology Biomarkers Biomechanics Biopsy Calibration Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - drug therapy Cerebral infarction Computer applications Computer Simulation Diabetes mellitus Drug therapy Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Gene expression Humans Inflammation Information technology Instability Ischemia Lipids Lymphocytes Macrophages Medicin och hälsovetenskap Morphology Muscles Myocardial infarction Patients Peptides Pharmacology Pilot Projects Plaque, Atherosclerotic Plaques Polypharmacy Precision Medicine Protein interaction Proteins Proteomics Scale models Simulation Smooth muscle Stability Stability analysis Stroke Systems biology
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