Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integr...

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Veröffentlicht in:	Nature genetics 2023, Vol.55 (1), p.89-99
Hauptverfasser:	Fernandez-Rozadilla, Ceres, Chen, Zhishan, Law, Philip, Thomas, Minta, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Lu, Yingchang, Broderick, Peter, Conti, David, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Shin, Min-Ho, Shin, Aesun, Kim, Dong-Hyun, Oze, Isao, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jenkins, Mark, Figueiredo, Jane, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Maughan, Timothy, Kerr, Rachel, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Aaltonen, Lauri, Rissanen, Harri, Eriksson, Johan, Cajuso, Tatiana, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Albanes, Demetrius, Weinstein, Stephanie, Platz, Elizabeth, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Castellví-Bel, Sergi, Arndt, Volker, Bishop, Timothy, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Lejbkowicz, Flavio, Offit, Kenneth, Steinfelder, Robert, van Guelpen, Bethany, Hudson, Thomas, Berndt, Sonja, Hayes, Richard, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Pugh, Elizabeth, Cruz-Correa, Marcia, Hunter, David, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Edlund, Chistopher, Gauderman, William, Shibata, David, van Duijnhoven, Franzel, Feskens, Edith, Wolk, Alicja, Naccarati, Alessio, Lee, Soo Chin, Bien, Stephanie, Lin, Yi, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Sawada, Norie, Iwasaki, Motoki, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Zheng, Wei, Peters, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/177 631/208/205/2138 631/337/2019 692/699/67/1504/1885 Agriculture Animal Genetics and Genomics Asian people Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell adhesion Cell migration Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics DNA methylation East Asian People - genetics European People - genetics Gene expression Gene Function Genes Genetic Predisposition to Disease Genetics Genome-wide association studies Genome-Wide Association Study Genomes Growth factors Homeostasis Human Genetics Humans Microorganisms Mucosa Multiomics Polymorphism, Single Nucleotide - genetics Risk analysis Transcriptomes Transcriptomics Tumorigenesis
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