A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans

Cholestasis is characterized by intrahepatic accumulation of bile constituents, including bile acids (BAs), which promote liver damage. The apical sodium-dependent BA transporter (ASBT) plays an important role in BA reabsorption and signaling in ileum, bile ducts, and kidneys. Our aim was to investi...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2023-09, Vol.78 (3), p.709-726
Hauptverfasser:	Caballero-Camino, Francisco J, Rodrigues, Pedro M, Wångsell, Fredrik, Agirre-Lizaso, Aloña, Olaizola, Paula, Izquierdo-Sanchez, Laura, Perugorria, Maria J, Bujanda, Luis, Angelin, Bo, Straniero, Sara, Wallebäck, Anna, Starke, Ingemar, Gillberg, Per-Göran, Strängberg, Ellen, Bonn, Britta, Mattsson, Jan P, Madsen, Martin R, Hansen, Henrik H, Lindström, Erik, Åkerblad, Peter, Banales, Jesus M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Bile Acids and Salts - therapeutic use Bile Ducts Cholestasis - drug therapy Humans Liver Membrane Transport Proteins Mice Organic Anion Transporters, Sodium-Dependent Original : Immune-Mediated Diseases, DILI, and Biliary Tract Disease Rats Symporters
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