Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer
Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillo...
Gespeichert in:
| Veröffentlicht in: | Cancers 2023-03, Vol.15 (7), p.1959 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | 1959 |
| container_title | Cancers |
| container_volume | 15 |
| creator | Saba, Nabil F Pamulapati, Saagar Patel, Bhamini Mody, Mayur Strojan, Primož Takes, Robert Mäkitie, Antti A Cohen, Oded Pace-Asciak, Pia Vermorken, Jan B Bradford, Carol Forastiere, Arlene Teng, Yong Wieland, Andreas Ferlito, Alfio |
| description | Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillomavirus (HPV) is increasing rapidly. The treatment for OPSCC is multifaceted, with a recently emerging focus on immunotherapeutic approaches. With the increased incidence of HPV-related OPSCC and the approval of immunotherapy in the management of recurrent and metastatic HNC, there has been rising interest in exploring the role of immunotherapy in the treatment of HPV-related OPSCC specifically. The immune microenvironment in HPV-related disease is distinct from that in HPV-negative OPSCC, which has prompted further research into various immunotherapeutics. This review focuses on HPV-related OPSCC, its immune characteristics, and current challenges and future opportunities for immunotherapeutic applications in this virus-driven cancer. |
| doi_str_mv | 10.3390/cancers15071959 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_446543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A746926051</galeid><sourcerecordid>A746926051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-69d404e875027b463385574a7e5c072cf4fc35b1390f404f8f67be9287ad813</originalsourceid><addsrcrecordid>eNptkt9LHDEQx4O0qFiffSsLfenLajY_N0_lOGxPEC2t-Bpy2dm76G6yTXYt_e-b612tJ00gGSaf72RmGITOKnxOqcIX1ngLMVUcy0pxdYCOCZakFEKxNy_sI3Sa0gPOi9JKCnmIjqjETAhSHaPbm_AEXXHV95MP4xqiGWAanS1mwxCDsWtIxRiKuwhmdH5VLL7el9-gMyM0xQJMUxjfFDdgH4v5n2zeobet6RKc7u4T9P3z5d18UV7ffrmaz65Ly4kcS6EahhnUkmMil0xQWnMumZHAbc7btqy1lC-rXGabwbZuhVyCIrU0TV3RE1Ruo6afMExLPUTXm_hLB-P0zvWYLdCMCc5o5j9t-fzSQ2PBj9F0e7L9F-_WehWedIWxIqoWOcLHXYQYfkyQRt27ZKHrjIcwJU1qjEU-iMroh1foQ5iiz93QRCrFuRCY_KNWpgPtfBvyx3YTVM8kE4oIzDeFnv-HyruB3tngoXXZvye42ApsDClFaJ-LrLDeTI1-NTVZ8f5lb575vzNCfwOXyLxe</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2799556602</pqid></control><display><type>article</type><title>Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>PubMed Central Open Access</source><creator>Saba, Nabil F ; Pamulapati, Saagar ; Patel, Bhamini ; Mody, Mayur ; Strojan, Primož ; Takes, Robert ; Mäkitie, Antti A ; Cohen, Oded ; Pace-Asciak, Pia ; Vermorken, Jan B ; Bradford, Carol ; Forastiere, Arlene ; Teng, Yong ; Wieland, Andreas ; Ferlito, Alfio</creator><creatorcontrib>Saba, Nabil F ; Pamulapati, Saagar ; Patel, Bhamini ; Mody, Mayur ; Strojan, Primož ; Takes, Robert ; Mäkitie, Antti A ; Cohen, Oded ; Pace-Asciak, Pia ; Vermorken, Jan B ; Bradford, Carol ; Forastiere, Arlene ; Teng, Yong ; Wieland, Andreas ; Ferlito, Alfio</creatorcontrib><description>Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillomavirus (HPV) is increasing rapidly. The treatment for OPSCC is multifaceted, with a recently emerging focus on immunotherapeutic approaches. With the increased incidence of HPV-related OPSCC and the approval of immunotherapy in the management of recurrent and metastatic HNC, there has been rising interest in exploring the role of immunotherapy in the treatment of HPV-related OPSCC specifically. The immune microenvironment in HPV-related disease is distinct from that in HPV-negative OPSCC, which has prompted further research into various immunotherapeutics. This review focuses on HPV-related OPSCC, its immune characteristics, and current challenges and future opportunities for immunotherapeutic applications in this virus-driven cancer.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15071959</identifier><identifier>PMID: 37046621</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alcohol use ; Antigens ; Apoptosis ; Care and treatment ; Cell cycle ; Cell division ; Complications and side effects ; Cytotoxicity ; Disease prevention ; Head & neck cancer ; Head and neck cancer ; Human papillomavirus ; Immunology ; Immunotherapy ; Lymphocytes ; Malignancy ; Medical prognosis ; Metastases ; Methods ; Microenvironments ; Papillomavirus infections ; Proteins ; Radiation therapy ; Review ; Squamous cell carcinoma ; Surgery ; Tobacco ; Tumors</subject><ispartof>Cancers, 2023-03, Vol.15 (7), p.1959</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-69d404e875027b463385574a7e5c072cf4fc35b1390f404f8f67be9287ad813</citedby><cites>FETCH-LOGICAL-c527t-69d404e875027b463385574a7e5c072cf4fc35b1390f404f8f67be9287ad813</cites><orcidid>0000-0002-2245-6645 ; 0000-0003-4972-1477 ; 0000-0001-9648-7922 ; 0000-0002-0445-112X ; 0000-0002-0451-2404 ; 0000-0002-1856-7289 ; 0000-0002-8247-8002 ; 0000-0001-8515-7848</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092986/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092986/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37046621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:152497714$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Saba, Nabil F</creatorcontrib><creatorcontrib>Pamulapati, Saagar</creatorcontrib><creatorcontrib>Patel, Bhamini</creatorcontrib><creatorcontrib>Mody, Mayur</creatorcontrib><creatorcontrib>Strojan, Primož</creatorcontrib><creatorcontrib>Takes, Robert</creatorcontrib><creatorcontrib>Mäkitie, Antti A</creatorcontrib><creatorcontrib>Cohen, Oded</creatorcontrib><creatorcontrib>Pace-Asciak, Pia</creatorcontrib><creatorcontrib>Vermorken, Jan B</creatorcontrib><creatorcontrib>Bradford, Carol</creatorcontrib><creatorcontrib>Forastiere, Arlene</creatorcontrib><creatorcontrib>Teng, Yong</creatorcontrib><creatorcontrib>Wieland, Andreas</creatorcontrib><creatorcontrib>Ferlito, Alfio</creatorcontrib><title>Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillomavirus (HPV) is increasing rapidly. The treatment for OPSCC is multifaceted, with a recently emerging focus on immunotherapeutic approaches. With the increased incidence of HPV-related OPSCC and the approval of immunotherapy in the management of recurrent and metastatic HNC, there has been rising interest in exploring the role of immunotherapy in the treatment of HPV-related OPSCC specifically. The immune microenvironment in HPV-related disease is distinct from that in HPV-negative OPSCC, which has prompted further research into various immunotherapeutics. This review focuses on HPV-related OPSCC, its immune characteristics, and current challenges and future opportunities for immunotherapeutic applications in this virus-driven cancer.</description><subject>Alcohol use</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Care and treatment</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Complications and side effects</subject><subject>Cytotoxicity</subject><subject>Disease prevention</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Human papillomavirus</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Lymphocytes</subject><subject>Malignancy</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Methods</subject><subject>Microenvironments</subject><subject>Papillomavirus infections</subject><subject>Proteins</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Tobacco</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>D8T</sourceid><recordid>eNptkt9LHDEQx4O0qFiffSsLfenLajY_N0_lOGxPEC2t-Bpy2dm76G6yTXYt_e-b612tJ00gGSaf72RmGITOKnxOqcIX1ngLMVUcy0pxdYCOCZakFEKxNy_sI3Sa0gPOi9JKCnmIjqjETAhSHaPbm_AEXXHV95MP4xqiGWAanS1mwxCDsWtIxRiKuwhmdH5VLL7el9-gMyM0xQJMUxjfFDdgH4v5n2zeobet6RKc7u4T9P3z5d18UV7ffrmaz65Ly4kcS6EahhnUkmMil0xQWnMumZHAbc7btqy1lC-rXGabwbZuhVyCIrU0TV3RE1Ruo6afMExLPUTXm_hLB-P0zvWYLdCMCc5o5j9t-fzSQ2PBj9F0e7L9F-_WehWedIWxIqoWOcLHXYQYfkyQRt27ZKHrjIcwJU1qjEU-iMroh1foQ5iiz93QRCrFuRCY_KNWpgPtfBvyx3YTVM8kE4oIzDeFnv-HyruB3tngoXXZvye42ApsDClFaJ-LrLDeTI1-NTVZ8f5lb575vzNCfwOXyLxe</recordid><startdate>20230324</startdate><enddate>20230324</enddate><creator>Saba, Nabil F</creator><creator>Pamulapati, Saagar</creator><creator>Patel, Bhamini</creator><creator>Mody, Mayur</creator><creator>Strojan, Primož</creator><creator>Takes, Robert</creator><creator>Mäkitie, Antti A</creator><creator>Cohen, Oded</creator><creator>Pace-Asciak, Pia</creator><creator>Vermorken, Jan B</creator><creator>Bradford, Carol</creator><creator>Forastiere, Arlene</creator><creator>Teng, Yong</creator><creator>Wieland, Andreas</creator><creator>Ferlito, Alfio</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-2245-6645</orcidid><orcidid>https://orcid.org/0000-0003-4972-1477</orcidid><orcidid>https://orcid.org/0000-0001-9648-7922</orcidid><orcidid>https://orcid.org/0000-0002-0445-112X</orcidid><orcidid>https://orcid.org/0000-0002-0451-2404</orcidid><orcidid>https://orcid.org/0000-0002-1856-7289</orcidid><orcidid>https://orcid.org/0000-0002-8247-8002</orcidid><orcidid>https://orcid.org/0000-0001-8515-7848</orcidid></search><sort><creationdate>20230324</creationdate><title>Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer</title><author>Saba, Nabil F ; Pamulapati, Saagar ; Patel, Bhamini ; Mody, Mayur ; Strojan, Primož ; Takes, Robert ; Mäkitie, Antti A ; Cohen, Oded ; Pace-Asciak, Pia ; Vermorken, Jan B ; Bradford, Carol ; Forastiere, Arlene ; Teng, Yong ; Wieland, Andreas ; Ferlito, Alfio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-69d404e875027b463385574a7e5c072cf4fc35b1390f404f8f67be9287ad813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alcohol use</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>Care and treatment</topic><topic>Cell cycle</topic><topic>Cell division</topic><topic>Complications and side effects</topic><topic>Cytotoxicity</topic><topic>Disease prevention</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Human papillomavirus</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Lymphocytes</topic><topic>Malignancy</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Methods</topic><topic>Microenvironments</topic><topic>Papillomavirus infections</topic><topic>Proteins</topic><topic>Radiation therapy</topic><topic>Review</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Tobacco</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saba, Nabil F</creatorcontrib><creatorcontrib>Pamulapati, Saagar</creatorcontrib><creatorcontrib>Patel, Bhamini</creatorcontrib><creatorcontrib>Mody, Mayur</creatorcontrib><creatorcontrib>Strojan, Primož</creatorcontrib><creatorcontrib>Takes, Robert</creatorcontrib><creatorcontrib>Mäkitie, Antti A</creatorcontrib><creatorcontrib>Cohen, Oded</creatorcontrib><creatorcontrib>Pace-Asciak, Pia</creatorcontrib><creatorcontrib>Vermorken, Jan B</creatorcontrib><creatorcontrib>Bradford, Carol</creatorcontrib><creatorcontrib>Forastiere, Arlene</creatorcontrib><creatorcontrib>Teng, Yong</creatorcontrib><creatorcontrib>Wieland, Andreas</creatorcontrib><creatorcontrib>Ferlito, Alfio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saba, Nabil F</au><au>Pamulapati, Saagar</au><au>Patel, Bhamini</au><au>Mody, Mayur</au><au>Strojan, Primož</au><au>Takes, Robert</au><au>Mäkitie, Antti A</au><au>Cohen, Oded</au><au>Pace-Asciak, Pia</au><au>Vermorken, Jan B</au><au>Bradford, Carol</au><au>Forastiere, Arlene</au><au>Teng, Yong</au><au>Wieland, Andreas</au><au>Ferlito, Alfio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-03-24</date><risdate>2023</risdate><volume>15</volume><issue>7</issue><spage>1959</spage><pages>1959-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Head and neck cancer (HNC) is the seventh most common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) accounting for a majority of cases in the western world. While HNC accounts for only 5% of all cancers in the United States, the incidence of a subset of OPSCC caused by human papillomavirus (HPV) is increasing rapidly. The treatment for OPSCC is multifaceted, with a recently emerging focus on immunotherapeutic approaches. With the increased incidence of HPV-related OPSCC and the approval of immunotherapy in the management of recurrent and metastatic HNC, there has been rising interest in exploring the role of immunotherapy in the treatment of HPV-related OPSCC specifically. The immune microenvironment in HPV-related disease is distinct from that in HPV-negative OPSCC, which has prompted further research into various immunotherapeutics. This review focuses on HPV-related OPSCC, its immune characteristics, and current challenges and future opportunities for immunotherapeutic applications in this virus-driven cancer.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37046621</pmid><doi>10.3390/cancers15071959</doi><orcidid>https://orcid.org/0000-0002-2245-6645</orcidid><orcidid>https://orcid.org/0000-0003-4972-1477</orcidid><orcidid>https://orcid.org/0000-0001-9648-7922</orcidid><orcidid>https://orcid.org/0000-0002-0445-112X</orcidid><orcidid>https://orcid.org/0000-0002-0451-2404</orcidid><orcidid>https://orcid.org/0000-0002-1856-7289</orcidid><orcidid>https://orcid.org/0000-0002-8247-8002</orcidid><orcidid>https://orcid.org/0000-0001-8515-7848</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2023-03, Vol.15 (7), p.1959 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_446543 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access |
| subjects | Alcohol use Antigens Apoptosis Care and treatment Cell cycle Cell division Complications and side effects Cytotoxicity Disease prevention Head & neck cancer Head and neck cancer Human papillomavirus Immunology Immunotherapy Lymphocytes Malignancy Medical prognosis Metastases Methods Microenvironments Papillomavirus infections Proteins Radiation therapy Review Squamous cell carcinoma Surgery Tobacco Tumors |
| title | Novel Immunotherapeutic Approaches to Treating HPV-Related Head and Neck Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T17%3A45%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20Immunotherapeutic%20Approaches%20to%20Treating%20HPV-Related%20Head%20and%20Neck%20Cancer&rft.jtitle=Cancers&rft.au=Saba,%20Nabil%20F&rft.date=2023-03-24&rft.volume=15&rft.issue=7&rft.spage=1959&rft.pages=1959-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers15071959&rft_dat=%3Cgale_swepu%3EA746926051%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2799556602&rft_id=info:pmid/37046621&rft_galeid=A746926051&rfr_iscdi=true |