Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome

The transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female progeny are being revealed. As there is evidence that a male equivalent of PCOS may exists, we ask whether sons born to mothers with PCOS (PCOS-sons) transmit reproductive and metabolic phenotypes to their male prog...

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Veröffentlicht in:	Cell reports. Medicine 2023-05, Vol.4 (5), p.101035-101035, Article 101035
Hauptverfasser:	Risal, Sanjiv, Li, Congru, Luo, Qing, Fornes, Romina, Lu, Haojiang, Eriksson, Gustaw, Manti, Maria, Ohlsson, Claes, Lindgren, Eva, Crisosto, Nicolas, Maliqueo, Manuel, Echiburú, Barbara, Recabarren, Sergio, Petermann, Teresa Sir, Benrick, Anna, Brusselaers, Nele, Qiao, Jie, Deng, Qiaolin, Stener-Victorin, Elisabet
Format:	Artikel
Sprache:	eng
Schlagworte:	adipose tissue animal animal experiment animal model animal tissue Animals brothers case control study Case-Control Studies Cell Biology childhood obesity Clinical Medicine cohort analysis controlled study differential gene expression disease dyslipidemia Female fetus outcome fetus risk gene locus genetic risk genetics genital system disease germ line high risk infant high risk patient human Humans hyperandrogenism inheritance Klinisk medicin Male male offspring male offspring to male germline maternal fetal transmission maternal hyperandrogenism maternal obesity metabolic disorder Mice micrornas mouse nonhuman Obesity Obesity - genetics ovary polycystic disease pathway polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Pregnancy prenatal androgen exposure prenatal exposure progeny Reproduction Reproduction - genetics Research & Experimental Medicine risk assessment RNA analysis Semen small non-coding RNAs small untranslated RNA sons sperm susceptibility transgenerational transmission Translational Medicine TRIM Translationell medicin TRIM vertical transmission women
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