Modeling the Inflammatory Response of Traumatic Brain Injury Using Human Induced Pluripotent Stem Cell Derived Microglia

The neuroinflammatory response after traumatic brain injury (TBI) is implicated as a key mediator of secondary injury in both the acute and chronic periods after primary injury. Microglia are the key innate immune cell in the central nervous system, responding to injury with the release of cytokines...

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Veröffentlicht in:	Journal of neurotrauma 2023-10, Vol.40 (19-20), p.2164-2173
Hauptverfasser:	Alam, Aftab, Singh, Tanya, Kayhanian, Saeed, Tjerkaski, Jonathan, Garcia, Núria Marcó, Carpenter, Keri L H, Patani, Rickie, Lindblad, Caroline, Thelin, Eric P, Syed, Yasir Ahmed, Helmy, Adel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Injuries - complications Brain Injuries, Traumatic - complications cytokine Cytokines Disease Models, Animal Humans Induced Pluripotent Stem Cells inflammation Interleukin-10 Interleukin-4 Interleukin-6 Medicin och hälsovetenskap microdialysis microglia Microglia - pathology neuroinflammation traumatic brain injury Tumor Necrosis Factor-alpha
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