COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study
To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data. All people aged ≥18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sw...
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| Veröffentlicht in: | HIV medicine 2023-10, Vol.24 (10), p.1045-1055 |
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| creator | Möller, Isabela Killander Gisslén, Magnus Wagner, Philippe Sparén, Pär Carlander, Christina |
| description | To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data.
All people aged ≥18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors.
Data from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p |
| doi_str_mv | 10.1111/hiv.13515 |
| format | Article |
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All people aged ≥18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors.
Data from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p < 0.001), and larger proportions were men (p = 0.014) and migrants (p < 0.001). Almost all PWH had undetectable HIV-RNA (93%) and high CD4 T-cell counts (median = 560 cells/μL, interquartile range: 376-780). In an unadjusted model, PWH had statistically significant lower odds of severe COVID-19 compared with patients without HIV [odds ratio (OR) = 0.6, 95% confidence interval (CI): 0.34-0.94], but there was no significant difference after adjusting for age and comorbidity (adjusted OR = 0.7, 95% CI: 0.43-1.26). A statistically significant lower proportion of PWH (8%, 95% CI: 5-15%) died within 90 days compared with those without HIV (16%, 95% CI: 15-16%, p = 0.024). There was no statistically significant difference in days in hospital and complications during the hospital stay between PWH and patients without HIV.
In this nationwide study including well-treated PWH, HIV was not a risk factor in hospitalized patients for developing severe COVID-19.</description><identifier>ISSN: 1464-2662</identifier><identifier>ISSN: 1468-1293</identifier><identifier>EISSN: 1468-1293</identifier><identifier>DOI: 10.1111/hiv.13515</identifier><identifier>PMID: 37286199</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>CD4 antigen ; Clinical Medicine ; cohort ; comorbidities ; Comorbidity ; Complications ; Confidence intervals ; coronavirus disease 2019 ; COVID-19 ; death ; Health risks ; HIV ; Hospitalization ; Hospitals ; Human immunodeficiency virus ; infection ; Infectious Diseases ; Infectious Medicine ; Infektionsmedicin ; Klinisk medicin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; mortality ; Public health ; Regression analysis ; Risk factors ; SARS-CoV-2 ; Statistical analysis ; Statistical significance</subject><ispartof>HIV medicine, 2023-10, Vol.24 (10), p.1045-1055</ispartof><rights>2023 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c646t-5cad548e48eb81325b0d69959c8313cc5612ad1d86b5f5f994e99f869649738d3</citedby><cites>FETCH-LOGICAL-c646t-5cad548e48eb81325b0d69959c8313cc5612ad1d86b5f5f994e99f869649738d3</cites><orcidid>0000-0002-4105-2902 ; 0000-0001-9962-5964</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,552,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37286199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520161$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/327429$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/22e2ea1a-e16c-41a8-bc82-a9d97ae25ab0$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:153003106$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Möller, Isabela Killander</creatorcontrib><creatorcontrib>Gisslén, Magnus</creatorcontrib><creatorcontrib>Wagner, Philippe</creatorcontrib><creatorcontrib>Sparén, Pär</creatorcontrib><creatorcontrib>Carlander, Christina</creatorcontrib><title>COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study</title><title>HIV medicine</title><addtitle>HIV Med</addtitle><description>To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data.
All people aged ≥18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors.
Data from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p < 0.001), and larger proportions were men (p = 0.014) and migrants (p < 0.001). Almost all PWH had undetectable HIV-RNA (93%) and high CD4 T-cell counts (median = 560 cells/μL, interquartile range: 376-780). In an unadjusted model, PWH had statistically significant lower odds of severe COVID-19 compared with patients without HIV [odds ratio (OR) = 0.6, 95% confidence interval (CI): 0.34-0.94], but there was no significant difference after adjusting for age and comorbidity (adjusted OR = 0.7, 95% CI: 0.43-1.26). A statistically significant lower proportion of PWH (8%, 95% CI: 5-15%) died within 90 days compared with those without HIV (16%, 95% CI: 15-16%, p = 0.024). There was no statistically significant difference in days in hospital and complications during the hospital stay between PWH and patients without HIV.
In this nationwide study including well-treated PWH, HIV was not a risk factor in hospitalized patients for developing severe COVID-19.</description><subject>CD4 antigen</subject><subject>Clinical Medicine</subject><subject>cohort</subject><subject>comorbidities</subject><subject>Comorbidity</subject><subject>Complications</subject><subject>Confidence intervals</subject><subject>coronavirus disease 2019</subject><subject>COVID-19</subject><subject>death</subject><subject>Health risks</subject><subject>HIV</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>infection</subject><subject>Infectious Diseases</subject><subject>Infectious Medicine</subject><subject>Infektionsmedicin</subject><subject>Klinisk medicin</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>mortality</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>SARS-CoV-2</subject><subject>Statistical analysis</subject><subject>Statistical significance</subject><issn>1464-2662</issn><issn>1468-1293</issn><issn>1468-1293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>D8T</sourceid><recordid>eNp9kl1rFDEUhgdRbLt64R-QAW8UnJqTr0nwqmzVLiz0RvdOQr5mmzo7s51MLNtfb_ajFYQ15JDD4XlfziGnKN4AOod8Pt2E3-dAGLBnxSlQLirAkjzf5bTCnOOT4izGW4SgJhK9LE5IjQUHKU-Ln9PrxeyyAlne9HEdRt2GBz2Gviv7NNp-5WMZulK71I6xNJvyarYo46jHFD-Xuux2aHUfnC8Hvwxx9ENldPQuQ8ltXhUvGt1G__rwToofX798n15V8-tvs-nFvLKc8rFiVjtGhc_XCCCYGeS4lExaQYBYyzhg7cAJbljDGimpl7IRXHIqayIcmRTV3jfe-3Uyaj2ElR42qtdBHUq_cuYVpazGkHl5lF8PvfsrehQCIwgRQDxr50e1bVrnMDm2Gow99hq08sCtoqCFMlZgpaWTtfaYaYP-2_oy2-XScudGcE3zt06Kj0f5y7C4UP2wVCkphhHw7aTv93ge6y75OKpViNa3re58n6LCAhMpoYYt-u4f9LZPQ5f_LVM1ZkLSWmTqw56yQx_j4JunDgCp7TaqvI1qt42ZfXtwTGbl3RP5uH7kD6P62sE</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Möller, Isabela Killander</creator><creator>Gisslén, Magnus</creator><creator>Wagner, Philippe</creator><creator>Sparén, Pär</creator><creator>Carlander, Christina</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>ACNBI</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DF2</scope><scope>ZZAVC</scope><scope>F1U</scope><scope>AGCHP</scope><scope>D95</scope><orcidid>https://orcid.org/0000-0002-4105-2902</orcidid><orcidid>https://orcid.org/0000-0001-9962-5964</orcidid></search><sort><creationdate>20231001</creationdate><title>COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study</title><author>Möller, Isabela Killander ; Gisslén, Magnus ; Wagner, Philippe ; Sparén, Pär ; Carlander, Christina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c646t-5cad548e48eb81325b0d69959c8313cc5612ad1d86b5f5f994e99f869649738d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>CD4 antigen</topic><topic>Clinical Medicine</topic><topic>cohort</topic><topic>comorbidities</topic><topic>Comorbidity</topic><topic>Complications</topic><topic>Confidence intervals</topic><topic>coronavirus disease 2019</topic><topic>COVID-19</topic><topic>death</topic><topic>Health risks</topic><topic>HIV</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>infection</topic><topic>Infectious Diseases</topic><topic>Infectious Medicine</topic><topic>Infektionsmedicin</topic><topic>Klinisk medicin</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>mortality</topic><topic>Public health</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>SARS-CoV-2</topic><topic>Statistical analysis</topic><topic>Statistical significance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Möller, Isabela Killander</creatorcontrib><creatorcontrib>Gisslén, Magnus</creatorcontrib><creatorcontrib>Wagner, Philippe</creatorcontrib><creatorcontrib>Sparén, Pär</creatorcontrib><creatorcontrib>Carlander, Christina</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SWEPUB Lunds universitet</collection><jtitle>HIV medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Möller, Isabela Killander</au><au>Gisslén, Magnus</au><au>Wagner, Philippe</au><au>Sparén, Pär</au><au>Carlander, Christina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study</atitle><jtitle>HIV medicine</jtitle><addtitle>HIV Med</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>24</volume><issue>10</issue><spage>1045</spage><epage>1055</epage><pages>1045-1055</pages><issn>1464-2662</issn><issn>1468-1293</issn><eissn>1468-1293</eissn><abstract>To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data.
All people aged ≥18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors.
Data from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p < 0.001), and larger proportions were men (p = 0.014) and migrants (p < 0.001). Almost all PWH had undetectable HIV-RNA (93%) and high CD4 T-cell counts (median = 560 cells/μL, interquartile range: 376-780). In an unadjusted model, PWH had statistically significant lower odds of severe COVID-19 compared with patients without HIV [odds ratio (OR) = 0.6, 95% confidence interval (CI): 0.34-0.94], but there was no significant difference after adjusting for age and comorbidity (adjusted OR = 0.7, 95% CI: 0.43-1.26). A statistically significant lower proportion of PWH (8%, 95% CI: 5-15%) died within 90 days compared with those without HIV (16%, 95% CI: 15-16%, p = 0.024). There was no statistically significant difference in days in hospital and complications during the hospital stay between PWH and patients without HIV.
In this nationwide study including well-treated PWH, HIV was not a risk factor in hospitalized patients for developing severe COVID-19.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37286199</pmid><doi>10.1111/hiv.13515</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4105-2902</orcidid><orcidid>https://orcid.org/0000-0001-9962-5964</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Journals; SWEPUB Freely available online |
| subjects | CD4 antigen Clinical Medicine cohort comorbidities Comorbidity Complications Confidence intervals coronavirus disease 2019 COVID-19 death Health risks HIV Hospitalization Hospitals Human immunodeficiency virus infection Infectious Diseases Infectious Medicine Infektionsmedicin Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap mortality Public health Regression analysis Risk factors SARS-CoV-2 Statistical analysis Statistical significance |
| title | COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study |
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