Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism

Adult stem cells are long-lived and quiescent with unique metabolic requirements. Macroautophagy/autophagy is a fundamental survival mechanism that allows cells to adapt to metabolic changes by degrading and recycling intracellular components. Here we address why autophagy depletion leads to a drast...

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Veröffentlicht in:	Autophagy 2024, Vol.20 (1), p.45-57
Hauptverfasser:	Borsa, Mariana, Obba, Sandrine, Richter, Felix C., Zhang, Hanlin, Riffelmacher, Thomas, Carrelha, Joana, Alsaleh, Ghada, Jacobsen, Sten Eirik W., Simon, Anna Katharina
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Animals Autophagy hematopoietic stem cells Hematopoietic Stem Cells - metabolism Mechanistic Target of Rapamycin Complex 1 - metabolism Mechanistic Target of Rapamycin Complex 2 - metabolism Medicin och hälsovetenskap Mice MTOR Phosphatidylinositol 3-Kinases - metabolism rapamycin Research Paper Signal Transduction Sirolimus - pharmacology translation
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