Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8

Mice lacking CD4 and/or CD8 gene expression, generated by embryonic stem-cell technology, were used to study the role of CD4 + and CD8 + cells in the resistance to the acute infection with virulent (Tulahuén and RA) or mild (CA-I) strains of Trypanosoma cruzi. The presence of both CD4 + and CD8 + ce...

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Veröffentlicht in:	Immunology letters 1995-02, Vol.45 (1), p.53-60
Hauptverfasser:	Rottenberg, Martín E., Riarte, Adelina, Sporrong, Lena, Altcheh, Jaime, Petray, Patricia, Ruiz, Andrés M., Wigzell, Hans, Örn, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Animals Antigens, Protozoan - immunology CD4 CD4 Antigens - genetics CD4 Antigens - physiology CD4-Positive T-Lymphocytes - immunology CD8 CD8 Antigens - genetics CD8 Antigens - physiology CD8-Positive T-Lymphocytes - immunology Chagas Disease - complications Chagas Disease - immunology Chagas' disease H-2 Antigens - immunology Immunoglobulin G - immunology Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - immunology Mice Mice, Knockout Molecular Sequence Data Resistance T cell Trypanosoma cruzi Trypanosoma cruzi - immunology Trypanosoma cruzi - pathogenicity Virulence
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