The Relationship Between Proliferating Cell Nuclear Antigen (PCNA), Nuclear DNA Content and Mutant p53 During Genesis of Cervical Carcinoma
Proliferating cell nuclear antigen (PCNA), nuclear DNA content and mutant p53 overexpression were studied by means of image cytometry and immunohistochemistry respectively in normal mucosa (n = 10), in mild (n = 16), moderate (n = 9) and severe (n = 17) atypical lesions, as well as in squamous cell...
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| Veröffentlicht in: | Acta oncologica 1995, Vol.34 (2), p.171-176 |
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| container_title | Acta oncologica |
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| creator | Steinbeck, Rüdiger G. Heselmeyer, Kerstin M. Moberger, H. Birgitta Auer, Gert U. |
| description | Proliferating cell nuclear antigen (PCNA), nuclear DNA content and mutant p53 overexpression were studied by means of image cytometry and immunohistochemistry respectively in normal mucosa (n = 10), in mild (n = 16), moderate (n = 9) and severe (n = 17) atypical lesions, as well as in squamous cell carcinomas (n = 36) of the cervix uteri. The results show that increasing histopathological atypia in the cervical mucosa was correlated to an initial increase of PCNA followed by distinct aneuploidy and p53 overexpression. The data are suggested to contribute to a better understanding of the genesis of cervical carcinoma, and to indicate that the coexistence of both distinct aneuploidy and p53 immunoreactivity can be used to decide if a cell population is neoplastic, whereas the absence of p53 overexpression does not necessarily exclude neoplasia. This diagnostic procedure can be suggested to improve early detection of intraepithelial squamous neoplasia. |
| doi_str_mv | 10.3109/02841869509093952 |
| format | Article |
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Birgitta ; Auer, Gert U.</creator><creatorcontrib>Steinbeck, Rüdiger G. ; Heselmeyer, Kerstin M. ; Moberger, H. Birgitta ; Auer, Gert U.</creatorcontrib><description>Proliferating cell nuclear antigen (PCNA), nuclear DNA content and mutant p53 overexpression were studied by means of image cytometry and immunohistochemistry respectively in normal mucosa (n = 10), in mild (n = 16), moderate (n = 9) and severe (n = 17) atypical lesions, as well as in squamous cell carcinomas (n = 36) of the cervix uteri. The results show that increasing histopathological atypia in the cervical mucosa was correlated to an initial increase of PCNA followed by distinct aneuploidy and p53 overexpression. The data are suggested to contribute to a better understanding of the genesis of cervical carcinoma, and to indicate that the coexistence of both distinct aneuploidy and p53 immunoreactivity can be used to decide if a cell population is neoplastic, whereas the absence of p53 overexpression does not necessarily exclude neoplasia. This diagnostic procedure can be suggested to improve early detection of intraepithelial squamous neoplasia.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/02841869509093952</identifier><identifier>PMID: 7718254</identifier><identifier>CODEN: ACTOEL</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Aneuploidy ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Cell Transformation, Neoplastic ; DNA, Neoplasm - analysis ; Female ; Female genital diseases ; Gene Expression ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Medicin och hälsovetenskap ; Proliferating Cell Nuclear Antigen - analysis ; Tumor Suppressor Protein p53 - analysis ; Tumors ; Uterine Cervical Dysplasia - diagnosis ; Uterine Cervical Dysplasia - pathology ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Acta oncologica, 1995, Vol.34 (2), p.171-176</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-8061b98fd4209662cfb10acd3f84ff106aa9089d261fb144de70acdf8a4414283</citedby><cites>FETCH-LOGICAL-c529t-8061b98fd4209662cfb10acd3f84ff106aa9089d261fb144de70acdf8a4414283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02841869509093952$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02841869509093952$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3491285$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7718254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1928582$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinbeck, Rüdiger G.</creatorcontrib><creatorcontrib>Heselmeyer, Kerstin M.</creatorcontrib><creatorcontrib>Moberger, H. Birgitta</creatorcontrib><creatorcontrib>Auer, Gert U.</creatorcontrib><title>The Relationship Between Proliferating Cell Nuclear Antigen (PCNA), Nuclear DNA Content and Mutant p53 During Genesis of Cervical Carcinoma</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Proliferating cell nuclear antigen (PCNA), nuclear DNA content and mutant p53 overexpression were studied by means of image cytometry and immunohistochemistry respectively in normal mucosa (n = 10), in mild (n = 16), moderate (n = 9) and severe (n = 17) atypical lesions, as well as in squamous cell carcinomas (n = 36) of the cervix uteri. The results show that increasing histopathological atypia in the cervical mucosa was correlated to an initial increase of PCNA followed by distinct aneuploidy and p53 overexpression. The data are suggested to contribute to a better understanding of the genesis of cervical carcinoma, and to indicate that the coexistence of both distinct aneuploidy and p53 immunoreactivity can be used to decide if a cell population is neoplastic, whereas the absence of p53 overexpression does not necessarily exclude neoplasia. This diagnostic procedure can be suggested to improve early detection of intraepithelial squamous neoplasia.</description><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Transformation, Neoplastic</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gene Expression</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Proliferating Cell Nuclear Antigen - analysis</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><subject>Tumors</subject><subject>Uterine Cervical Dysplasia - diagnosis</subject><subject>Uterine Cervical Dysplasia - pathology</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhiMEKkvhATgg-YAQSARsx05s9bSkUJDKUqEi9RZ5nXHXJbGDnVDxDLw0jjYsBwQnj-b__vFo_ix7TPCrgmD5GlPBiCglxxLLQnJ6J1uRkpOc0vLqbraa9TwBV_ezBzHeYIxpUfGj7KiqiKCcrbKflztAn6FTo_Uu7uyA3sB4C-DQRfCdNRCS4q5RDV2HNpPuQAW0dqO9Tsjzi3qzfvHy0D_drFHt3QhuRMq16OM0qlQOvECnU5jHnIGDaCPyJk0M361WHapV0Nb5Xj3M7hnVRXi0vMfZl3dvL-v3-fmnsw_1-jzXnMoxF7gkWylMyyiWZUm12RKsdFsYwYwhuFRKYiFbWpKkMNZCNctGKMYIo6I4zvL93HgLw7RthmB7FX40XtlmaX1NFTSMFbysEl_9kx-Cb_-YfhuJpIILmpzP9s6EfZsgjk1vo06nVA78FJuqoqSkfAbJHtTBxxjAHD4huJmjbv6KOnmeLMOnbQ_twbFkm_Sni65iurMJymkbD1jBJElbJuxkj1lnfOjVDlQ37rQK0Nz4KbiUxH-W-AW9YMQ7</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Steinbeck, Rüdiger G.</creator><creator>Heselmeyer, Kerstin M.</creator><creator>Moberger, H. Birgitta</creator><creator>Auer, Gert U.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>1995</creationdate><title>The Relationship Between Proliferating Cell Nuclear Antigen (PCNA), Nuclear DNA Content and Mutant p53 During Genesis of Cervical Carcinoma</title><author>Steinbeck, Rüdiger G. ; Heselmeyer, Kerstin M. ; Moberger, H. Birgitta ; Auer, Gert U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-8061b98fd4209662cfb10acd3f84ff106aa9089d261fb144de70acdf8a4414283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Transformation, Neoplastic</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gene Expression</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Proliferating Cell Nuclear Antigen - analysis</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><topic>Tumors</topic><topic>Uterine Cervical Dysplasia - diagnosis</topic><topic>Uterine Cervical Dysplasia - pathology</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinbeck, Rüdiger G.</creatorcontrib><creatorcontrib>Heselmeyer, Kerstin M.</creatorcontrib><creatorcontrib>Moberger, H. Birgitta</creatorcontrib><creatorcontrib>Auer, Gert U.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinbeck, Rüdiger G.</au><au>Heselmeyer, Kerstin M.</au><au>Moberger, H. Birgitta</au><au>Auer, Gert U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship Between Proliferating Cell Nuclear Antigen (PCNA), Nuclear DNA Content and Mutant p53 During Genesis of Cervical Carcinoma</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>1995</date><risdate>1995</risdate><volume>34</volume><issue>2</issue><spage>171</spage><epage>176</epage><pages>171-176</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><coden>ACTOEL</coden><abstract>Proliferating cell nuclear antigen (PCNA), nuclear DNA content and mutant p53 overexpression were studied by means of image cytometry and immunohistochemistry respectively in normal mucosa (n = 10), in mild (n = 16), moderate (n = 9) and severe (n = 17) atypical lesions, as well as in squamous cell carcinomas (n = 36) of the cervix uteri. The results show that increasing histopathological atypia in the cervical mucosa was correlated to an initial increase of PCNA followed by distinct aneuploidy and p53 overexpression. The data are suggested to contribute to a better understanding of the genesis of cervical carcinoma, and to indicate that the coexistence of both distinct aneuploidy and p53 immunoreactivity can be used to decide if a cell population is neoplastic, whereas the absence of p53 overexpression does not necessarily exclude neoplasia. This diagnostic procedure can be suggested to improve early detection of intraepithelial squamous neoplasia.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>7718254</pmid><doi>10.3109/02841869509093952</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Acta oncologica, 1995, Vol.34 (2), p.171-176 |
| issn | 0284-186X 1651-226X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Taylor & Francis Journals Complete |
| subjects | Aneuploidy Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Transformation, Neoplastic DNA, Neoplasm - analysis Female Female genital diseases Gene Expression Gynecology. Andrology. Obstetrics Humans Medical sciences Medicin och hälsovetenskap Proliferating Cell Nuclear Antigen - analysis Tumor Suppressor Protein p53 - analysis Tumors Uterine Cervical Dysplasia - diagnosis Uterine Cervical Dysplasia - pathology Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology |
| title | The Relationship Between Proliferating Cell Nuclear Antigen (PCNA), Nuclear DNA Content and Mutant p53 During Genesis of Cervical Carcinoma |
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