Increased cerebrospinal fluid concentration of nitrite in Parkinsonʼs disease
The concentration of nitrite, a metabolite of nitric oxide (NO), was increased in the cerebrospinal fluid (CSF) of untreated patients with Parkinsonʼs disease and in patients treated with L-DOPA in comparison with a group of patients without dopaminergic dysfunction. There was no difference in the c...
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| Veröffentlicht in: | Neuroreport 1995, Vol.6 (12), p.1642-1644 |
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| container_title | Neuroreport |
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| creator | Qureshi, G A Baig, S Bednar, I Södersten, P Forsberg, G Siden, A |
| description | The concentration of nitrite, a metabolite of nitric oxide (NO), was increased in the cerebrospinal fluid (CSF) of untreated patients with Parkinsonʼs disease and in patients treated with L-DOPA in comparison with a group of patients without dopaminergic dysfunction. There was no difference in the concentration of L- arginine (ARG), a precursor of NO, between the groups. There was a highly significant, linear relationship between the concentration of nitrite and ARG in the CSF suggesting that the production of NO is dependent on the availability of ARG. The results support the possibility thatproduction of NO is increased in the brain in Parkinsonʼs disease. |
| doi_str_mv | 10.1097/00001756-199508000-00013 |
| format | Article |
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Prion diseases ; Female ; Humans ; Levodopa - metabolism ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Neurology ; Nitric Oxide - metabolism ; Nitrites - cerebrospinal fluid ; Parkinson Disease - cerebrospinal fluid ; Parkinson Disease - metabolism ; Treatment Outcome</subject><ispartof>Neuroreport, 1995, Vol.6 (12), p.1642-1644</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5503-9c06e5a017d755f7fcc95947834fbea933c63d53c25441530d7526f10967abc93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3648788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8527732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1930576$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:28527732$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Qureshi, G A</creatorcontrib><creatorcontrib>Baig, S</creatorcontrib><creatorcontrib>Bednar, I</creatorcontrib><creatorcontrib>Södersten, P</creatorcontrib><creatorcontrib>Forsberg, G</creatorcontrib><creatorcontrib>Siden, A</creatorcontrib><title>Increased cerebrospinal fluid concentration of nitrite in Parkinsonʼs disease</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>The concentration of nitrite, a metabolite of nitric oxide (NO), was increased in the cerebrospinal fluid (CSF) of untreated patients with Parkinsonʼs disease and in patients treated with L-DOPA in comparison with a group of patients without dopaminergic dysfunction. 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Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Levodopa - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitrites - cerebrospinal fluid</subject><subject>Parkinson Disease - cerebrospinal fluid</subject><subject>Parkinson Disease - metabolism</subject><subject>Treatment Outcome</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkstu1DAUhi0EKkPhEZCyQOwCdnxfoopLpQpYUKk7y3FOVDMZZ7ATjXi3PkGfijNMOrOqENkkOf4-28f-CakYfceo1e8pPkxLVTNrJTX4V-8r_AlZMaF5LaW5eUpW1EpbC6vkc_KilJ-IWMrMGTkzstGaNyvy9TKFDL5AVwXI0OaxbGPyQ9UPc8TamAKkKfspjqka-yrFKccJqpiq7z6vYypjur8rVRfLfpaX5FnvhwKvlvc5uf708cfFl_rq2-fLiw9XdZCS8toGqkB6bKHTUva6DwF3KrThom_BW86D4p3koZFCMMkpYo3qsXWlfRssPyf1Yd6yg-3cum2OG59_u9FHt5TW-AVOiAZV5M2j_DaP3Ul6EJvliFDV_6kyy6nUCs23BxOxXzOUyW1iCTAMPsE4F6e1ElTjIv8CmTKS4T2f2gh4TyVDf9wNo24fDPcQDHcMhvsbDFRfL2vM7Qa6o3hq880y7kvwQ599CrEcMa6E0cYgJg7YbhwmyGU9zDvI7hb8MN26x2LJ_wDe39K7</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Qureshi, G A</creator><creator>Baig, S</creator><creator>Bednar, I</creator><creator>Södersten, P</creator><creator>Forsberg, G</creator><creator>Siden, A</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>1995</creationdate><title>Increased cerebrospinal fluid concentration of nitrite in Parkinsonʼs disease</title><author>Qureshi, G A ; Baig, S ; Bednar, I ; Södersten, P ; Forsberg, G ; Siden, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5503-9c06e5a017d755f7fcc95947834fbea933c63d53c25441530d7526f10967abc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Arginine - cerebrospinal fluid</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Levodopa - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitrites - cerebrospinal fluid</topic><topic>Parkinson Disease - cerebrospinal fluid</topic><topic>Parkinson Disease - metabolism</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qureshi, G A</creatorcontrib><creatorcontrib>Baig, S</creatorcontrib><creatorcontrib>Bednar, I</creatorcontrib><creatorcontrib>Södersten, P</creatorcontrib><creatorcontrib>Forsberg, G</creatorcontrib><creatorcontrib>Siden, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qureshi, G A</au><au>Baig, S</au><au>Bednar, I</au><au>Södersten, P</au><au>Forsberg, G</au><au>Siden, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased cerebrospinal fluid concentration of nitrite in Parkinsonʼs disease</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1995</date><risdate>1995</risdate><volume>6</volume><issue>12</issue><spage>1642</spage><epage>1644</epage><pages>1642-1644</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>The concentration of nitrite, a metabolite of nitric oxide (NO), was increased in the cerebrospinal fluid (CSF) of untreated patients with Parkinsonʼs disease and in patients treated with L-DOPA in comparison with a group of patients without dopaminergic dysfunction. 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| ispartof | Neuroreport, 1995, Vol.6 (12), p.1642-1644 |
| issn | 0959-4965 1473-558X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Arginine - cerebrospinal fluid Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Levodopa - metabolism Male Medical sciences Medicin och hälsovetenskap Middle Aged Neurology Nitric Oxide - metabolism Nitrites - cerebrospinal fluid Parkinson Disease - cerebrospinal fluid Parkinson Disease - metabolism Treatment Outcome |
| title | Increased cerebrospinal fluid concentration of nitrite in Parkinsonʼs disease |
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