Activation by Attention of the Human Reticular Formation and Thalamic Intralaminar Nuclei
It has been known for over 45 years that electrical stimulation of the midbrain reticular formation and of the thalamic intralaminar nuclei of the brain alerts animals. However, lesions of these sectors fail to impair arousal and vigilance in some cases, making the role of the ascending activating r...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-01, Vol.271 (5248), p.512-515 |
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| creator | Kinomura, Shigeo Larsson, Jonas Gulyás, Balázs Roland, Per E. |
| description | It has been known for over 45 years that electrical stimulation of the midbrain reticular formation and of the thalamic intralaminar nuclei of the brain alerts animals. However, lesions of these sectors fail to impair arousal and vigilance in some cases, making the role of the ascending activating reticular system controversial. Here, a positron emission tomographic study showed activation of the midbrain reticular formation and of thalamic intralaminar nuclei when human participants went from a relaxed awake state to an attention-demanding reaction-time task. These results confirm the role of these areas of the brain and brainstem in arousal and vigilance. |
| doi_str_mv | 10.1126/science.271.5248.512 |
| format | Article |
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However, lesions of these sectors fail to impair arousal and vigilance in some cases, making the role of the ascending activating reticular system controversial. Here, a positron emission tomographic study showed activation of the midbrain reticular formation and of thalamic intralaminar nuclei when human participants went from a relaxed awake state to an attention-demanding reaction-time task. 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Psychology ; Humans ; Intralaminar thalamic nuclei ; Localization (Brain function) ; Localization of functions ; Male ; Mesencephalon ; Mesencephalon - blood supply ; Mesencephalon - diagnostic imaging ; Mesencephalon - physiology ; Midbrain ; Midbrain tegmentum ; Neurons ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Reaction Time ; Regional Blood Flow ; Reticular formation ; Reticular Formation - blood supply ; Reticular Formation - diagnostic imaging ; Reticular Formation - physiology ; Stimulation ; Stimuli ; Thalamic Nuclei - blood supply ; Thalamic Nuclei - diagnostic imaging ; Thalamic Nuclei - physiology ; Thalamus ; Tomography, Emission-Computed ; Volunteers</subject><ispartof>Science (American Association for the Advancement of Science), 1996-01, Vol.271 (5248), p.512-515</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 26, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c819t-44661cd7868b867646cbd70fc95d80c20beb0c1ab7f1b7e67d4bbb47ed4fe97f3</citedby><cites>FETCH-LOGICAL-c819t-44661cd7868b867646cbd70fc95d80c20beb0c1ab7f1b7e67d4bbb47ed4fe97f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2890157$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2890157$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,777,781,800,882,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2984074$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8560267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1951411$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinomura, Shigeo</creatorcontrib><creatorcontrib>Larsson, Jonas</creatorcontrib><creatorcontrib>Gulyás, Balázs</creatorcontrib><creatorcontrib>Roland, Per E.</creatorcontrib><title>Activation by Attention of the Human Reticular Formation and Thalamic Intralaminar Nuclei</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>It has been known for over 45 years that electrical stimulation of the midbrain reticular formation and of the thalamic intralaminar nuclei of the brain alerts animals. However, lesions of these sectors fail to impair arousal and vigilance in some cases, making the role of the ascending activating reticular system controversial. Here, a positron emission tomographic study showed activation of the midbrain reticular formation and of thalamic intralaminar nuclei when human participants went from a relaxed awake state to an attention-demanding reaction-time task. These results confirm the role of these areas of the brain and brainstem in arousal and vigilance.</description><subject>Adult</subject><subject>Anatomical correlates of behavior</subject><subject>Anatomy</subject><subject>Arousal (Physiology)</subject><subject>Arousal (Psychophysiology)</subject><subject>Attention - physiology</subject><subject>Behavior</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Brain stem</subject><subject>Coordinate systems</subject><subject>Electroencephalography</subject><subject>Feedback (Response)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Intralaminar thalamic nuclei</subject><subject>Localization (Brain function)</subject><subject>Localization of functions</subject><subject>Male</subject><subject>Mesencephalon</subject><subject>Mesencephalon - blood supply</subject><subject>Mesencephalon - diagnostic imaging</subject><subject>Mesencephalon - physiology</subject><subject>Midbrain</subject><subject>Midbrain tegmentum</subject><subject>Neurons</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Reaction Time</subject><subject>Regional Blood Flow</subject><subject>Reticular formation</subject><subject>Reticular Formation - blood supply</subject><subject>Reticular Formation - diagnostic imaging</subject><subject>Reticular Formation - physiology</subject><subject>Stimulation</subject><subject>Stimuli</subject><subject>Thalamic Nuclei - blood supply</subject><subject>Thalamic Nuclei - diagnostic imaging</subject><subject>Thalamic Nuclei - physiology</subject><subject>Thalamus</subject><subject>Tomography, Emission-Computed</subject><subject>Volunteers</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN01Fr2zAQAGAzNrqs2z_owIwx9lBnki1Z8mMW1jQQGti6wZ6EJJ9TZY6UWva2_vsptUnJKDToQbLuk8B3uig6w2iMcZp_8tqA1TBOGR7TlPAxxemzaIRRQZMiRdnzaIRQliccMfoyeuX9GqEQK7KT6ITTHKU5G0U_J7o1v2VrnI3VXTxpW7D3H66K2xuIL7uNtPFXaI3uatnEF67Z9FraMr6-kbXcGB3PbdvcL20wV52uwbyOXlSy9vBmmE-j7xdfrqeXyWI5m08ni0RzXLQJIXmOdcl4zhXPWU5yrUqGKl3QkiOdIgUKaSwVq7BikLOSKKUIg5JUULAqO42S_l7_B7adEtvGbGRzJ5w0Ytj6FVYgCElpxoP_0Ptt42478K3YGK-hrqUF13nBWMExoumTMAv5pjlHT0LMEM5CEQJ89x9cu66xITsixRlliHIS0HmPVrIGYWzlQmr1CiyEDDsLlQnbE8wKirMCP_z-AQ-jhFCYx_zHAx9IC3_bley8F_NvV0fT5Y-j6efZsZTPFgf0_DGqXV3DCkR4RtPlASc9143zvoFq_xYwEruWEUPLiNAyYtcyIpQwHHs7VKVTGyj3h4YeCfH3Q1x6LeuqkVYbv2dpwQliu7qd9WztW9c8hHmBMGXZPzv0JQQ</recordid><startdate>19960126</startdate><enddate>19960126</enddate><creator>Kinomura, Shigeo</creator><creator>Larsson, Jonas</creator><creator>Gulyás, Balázs</creator><creator>Roland, Per E.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19960126</creationdate><title>Activation by Attention of the Human Reticular Formation and Thalamic Intralaminar Nuclei</title><author>Kinomura, Shigeo ; 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Psychology</topic><topic>Humans</topic><topic>Intralaminar thalamic nuclei</topic><topic>Localization (Brain function)</topic><topic>Localization of functions</topic><topic>Male</topic><topic>Mesencephalon</topic><topic>Mesencephalon - blood supply</topic><topic>Mesencephalon - diagnostic imaging</topic><topic>Mesencephalon - physiology</topic><topic>Midbrain</topic><topic>Midbrain tegmentum</topic><topic>Neurons</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. 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However, lesions of these sectors fail to impair arousal and vigilance in some cases, making the role of the ascending activating reticular system controversial. Here, a positron emission tomographic study showed activation of the midbrain reticular formation and of thalamic intralaminar nuclei when human participants went from a relaxed awake state to an attention-demanding reaction-time task. These results confirm the role of these areas of the brain and brainstem in arousal and vigilance.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8560267</pmid><doi>10.1126/science.271.5248.512</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-01, Vol.271 (5248), p.512-515 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_442538 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Adult Anatomical correlates of behavior Anatomy Arousal (Physiology) Arousal (Psychophysiology) Attention - physiology Behavior Behavioral psychophysiology Biological and medical sciences Brain Brain Mapping Brain stem Coordinate systems Electroencephalography Feedback (Response) Fundamental and applied biological sciences. Psychology Humans Intralaminar thalamic nuclei Localization (Brain function) Localization of functions Male Mesencephalon Mesencephalon - blood supply Mesencephalon - diagnostic imaging Mesencephalon - physiology Midbrain Midbrain tegmentum Neurons Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reaction Time Regional Blood Flow Reticular formation Reticular Formation - blood supply Reticular Formation - diagnostic imaging Reticular Formation - physiology Stimulation Stimuli Thalamic Nuclei - blood supply Thalamic Nuclei - diagnostic imaging Thalamic Nuclei - physiology Thalamus Tomography, Emission-Computed Volunteers |
| title | Activation by Attention of the Human Reticular Formation and Thalamic Intralaminar Nuclei |
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