Nomenclature for human CYP2D6 alleles
To standardize CYP2D6 allele nomenclature, and to conform with international human gene nomenclature guidelines, an alternative to the current arbitrary system is described. Based on recommendations for human genome nomenclature, we propose that alleles be designated by CYP2D6 followed by an asteris...
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| Veröffentlicht in: | Pharmacogenetics (London) 1996-06, Vol.6 (3), p.193-201 |
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| container_title | Pharmacogenetics (London) |
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| creator | DALY, A. K BROCKMÖLLER, J JACQZ-AIGRAIN, E MEYER, U. A NEBERT, D. W STEEN, V. M WOLF, C. R ZANGER, U. M BROLY, F EICHELBAUM, M EVANS, W. E GONZALEZ, F. J HUANG, J.-D IDLE, J. R INGELMAN-SUNDBERG, M ISHIZAKI, T |
| description | To standardize CYP2D6 allele nomenclature, and to conform with international human gene nomenclature guidelines, an alternative to the current arbitrary system is described. Based on recommendations for human genome nomenclature, we propose that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations. Criteria for classification as a separate allele and protein nomenclature are also presented. |
| doi_str_mv | 10.1097/00008571-199606000-00001 |
| format | Article |
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K ; BROCKMÖLLER, J ; JACQZ-AIGRAIN, E ; MEYER, U. A ; NEBERT, D. W ; STEEN, V. M ; WOLF, C. R ; ZANGER, U. M ; BROLY, F ; EICHELBAUM, M ; EVANS, W. E ; GONZALEZ, F. J ; HUANG, J.-D ; IDLE, J. R ; INGELMAN-SUNDBERG, M ; ISHIZAKI, T</creator><creatorcontrib>DALY, A. K ; BROCKMÖLLER, J ; JACQZ-AIGRAIN, E ; MEYER, U. A ; NEBERT, D. W ; STEEN, V. M ; WOLF, C. R ; ZANGER, U. M ; BROLY, F ; EICHELBAUM, M ; EVANS, W. E ; GONZALEZ, F. J ; HUANG, J.-D ; IDLE, J. R ; INGELMAN-SUNDBERG, M ; ISHIZAKI, T</creatorcontrib><description>To standardize CYP2D6 allele nomenclature, and to conform with international human gene nomenclature guidelines, an alternative to the current arbitrary system is described. Based on recommendations for human genome nomenclature, we propose that alleles be designated by CYP2D6 followed by an asterisk and a combination of roman letters and arabic numerals distinct for each allele with the number specifying the key mutation and, where appropriate, a letter specifying additional mutations. Criteria for classification as a separate allele and protein nomenclature are also presented.</description><identifier>ISSN: 0960-314X</identifier><identifier>DOI: 10.1097/00008571-199606000-00001</identifier><identifier>PMID: 8807658</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams and Wilkins</publisher><subject>Alleles ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; Cytochrome P-450 CYP2D6 - genetics ; Cytochrome P-450 CYP2D6 - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Amplification ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Guidelines as Topic ; Human ; Humans ; Multigene Family ; Mutation ; Terminology as Topic</subject><ispartof>Pharmacogenetics (London), 1996-06, Vol.6 (3), p.193-201</ispartof><rights>1996 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-b88be6943884a4d48db4a6f3e08d544cc40f503e55a6dea9564b490b879ab2743</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27913,27914</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3128970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8807658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1938484$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>DALY, A. 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Criteria for classification as a separate allele and protein nomenclature are also presented.</description><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cytochrome P-450 CYP2D6 - genetics</subject><subject>Cytochrome P-450 CYP2D6 - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Amplification</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Guidelines as Topic</subject><subject>Human</subject><subject>Humans</subject><subject>Multigene Family</subject><subject>Mutation</subject><subject>Terminology as Topic</subject><issn>0960-314X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRb0AlVL4BKQsgF3Ajt9LVJ4SAhYgwcqyk4kIOEmxGyH-HpeGeDOeM3fuSBehjOAzgrU8x-kpLklOtBZYpC7fILKD5jiBnBL2uof2Y_xIkFNazNBMKSwFV3N08tC30JXerocAWd2H7H1obZct356KS5FZ78FDPEC7tfURDse6QC_XV8_L2_z-8eZueXGflwwX69wp5UBoRpVillVMVY5ZUVPAquKMlUlVc0yBcysqsJoL5pjGTkltXSEZXaB86xu_YTU4swpNa8OP6W1jRvSZfmAYw5KqpD_d6leh_xogrk3bxBK8tx30QzRS0ULrYmOstsIy9DEGqCdrgs0mRfOfoplS_EMkrR6NNwbXQjUtjhGm-fE4t7G0vg62K5s4ySgplJaY_gLgMHnx</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>DALY, A. 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| ispartof | Pharmacogenetics (London), 1996-06, Vol.6 (3), p.193-201 |
| issn | 0960-314X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Alleles Biological and medical sciences Classical genetics, quantitative genetics, hybrids Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Fundamental and applied biological sciences. Psychology Gene Amplification Genetics of eukaryotes. Biological and molecular evolution Genotype Guidelines as Topic Human Humans Multigene Family Mutation Terminology as Topic |
| title | Nomenclature for human CYP2D6 alleles |
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