Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β

Experimental autoimmune encephalomyelitis (EAE) in rats is typically a brief and monophasic disease with sparse demyelination. However, inbred DA rats develop a demyelinating, prolonged and relapsing encephalomyelitis after immunization with rat spinal cord in incomplete Freund's adjuvant. This...

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Veröffentlicht in:	Journal of neuroimmunology 1996-09, Vol.69 (1), p.103-115
Hauptverfasser:	Issazadeh, Shohreh, Lorentzen, Johnny C., Mustafa, Maha I., Höjeberg, Bo, Miissener, Åsa, Olsson, Tomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal Cytokines - genetics Cytokines - metabolism Cytolysin Encephalomyelitis, Autoimmune, Experimental - immunology Gene Expression Immunohistochemistry Interferon-γ Interleukin-1 Interleukin-10 Interleukin-10 - genetics Interleukin-12 Interleukin-1β Male Medicin och hälsovetenskap Molecular Sequence Data Multiple sclerosis Myelin Basic Protein - chemistry Myelin Basic Protein - immunology Peptide Fragments - chemistry Peptide Fragments - immunology Rats Rats, Inbred Lew Rats, Inbred Strains RNA, Messenger - genetics Spinal Cord - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factor-β Tumor necrosis factor-α Tumor necrosis factor-β
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