Shift from anti-to proinflammatory cytokine profiles in microglia through LPS-or IFN-γ-mediated pathways

In this study, cytokine mRNA profiles in microglia from newborn rats were detected by in situ hybridization. Under natural culture conditions, microglia expressed the immunosuppressive transforming growth factor-β1 (TGF-β1) and interleukin (IL) 10 to a greater degree than the pro-inflammatory cytoki...

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Veröffentlicht in:	Neuroreport 1996-08, Vol.7 (12), p.1893-1898
Hauptverfasser:	Xiao, Bao-Guo, Bai, Xue-Feng, Zhang, Guang-Xian, Höjeberg, Bo, Link, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - metabolism Biological and medical sciences Cell Count - drug effects Cytokines - metabolism Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology In Situ Hybridization Interferon-gamma - pharmacology Isolated neuron and nerve. Neuroglia Lipopolysaccharides - pharmacology Medicin och hälsovetenskap Microglia - drug effects Microglia - metabolism Rats Rats, Inbred Lew Vertebrates: nervous system and sense organs
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