Subacute toluene exposure increases DA dysfunction in the 6-OH dopamine lesioned nigrostriatal dopaminergic system of the rat

The potential neurotoxicity of the solvent toluene to the nigrostriatal dopaminergic system was assessed in a rat model of Parkinson's disease. Rats, 1 day after a unilateral injection of 6-hydroxydopamine (6-OH DA) into the substantia nigra, inhaled air or different concentrations of toluene (...

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Veröffentlicht in:	Neuroscience letters 1996, Vol.217 (1), p.61-65
Hauptverfasser:	Cintra, A., Andbjer, B., Finnman, U.-B., Hagman, M., Agnati, L.F., Höglund, G., Fuxe, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism 6-Hydroxydopamine Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Dopamine - metabolism Dopamine - physiology Drug Administration Schedule Drug Synergism Male Medical sciences Medicin och hälsovetenskap Neostriatum Neurotoxicity Neurotoxins - toxicity Norepinephrine - metabolism Oxidopamine - toxicity Parkinson Disease, Secondary - chemically induced Parkinson's disease Rat Rats Rats, Sprague-Dawley Solvents Substantia nigra Substantia Nigra - drug effects Substantia Nigra - metabolism Toluene Toluene - toxicity Toxicology
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