A search for association between schizophrenia and dopamine-related alleles
Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic patients and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significan...
Gespeichert in:
| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 1996, Vol.246 (6), p.297-304 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 304 |
|---|---|
| container_issue | 6 |
| container_start_page | 297 |
| container_title | European archives of psychiatry and clinical neuroscience |
| container_volume | 246 |
| creator | Jönsson, E Brené, S Geijer, T Terenius, L Tylec, A Persson, M L Sedvall, G |
| description | Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic patients and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparisons. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizophrenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia. |
| doi_str_mv | 10.1007/bf02189022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_439895</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78522542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-b509531bed902f81b8293a1c7a88c822f8263d84a45928f26737cb200fcb446d3</originalsourceid><addsrcrecordid>eNp1kc1Lw0AQxRdRaq1evAt78iBE9yvN5liLVbHgRc_LfkxoNM3G3YSif70pTevJ0wzD77038BC6pOSWEpLdmYIwKnPC2BEaU8F5IkVOj9GY5IIklHNxis5i_CCE0JSRERr1sBSUjtHLDEfQwa5w4QPWMXpb6rb0NTbQbgBqHO2q_PHNKkBdaqxrh51v9LqsIQlQ6RYc1lUFFcRzdFLoKsLFMCfoffHwNn9Klq-Pz_PZMrGCizYxKclTTg24_uNCUiNZzjW1mZbSStaf2JQ7KbRIcyYLNs14Zg0jpLBGiKnjE5TsfOMGms6oJpRrHb6V16UaTp_9BkrwXPZRE5T9yzfBuz_RXkhzngmyVV7vlD321UFs1bqMFqpK1-C7qDKZMpYK1oM3O9AGH2OA4hBCidp2pO4X-456-Gpw7cwa3AEdSuG_4DqMug</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78522542</pqid></control><display><type>article</type><title>A search for association between schizophrenia and dopamine-related alleles</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jönsson, E ; Brené, S ; Geijer, T ; Terenius, L ; Tylec, A ; Persson, M L ; Sedvall, G</creator><creatorcontrib>Jönsson, E ; Brené, S ; Geijer, T ; Terenius, L ; Tylec, A ; Persson, M L ; Sedvall, G</creatorcontrib><description>Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic patients and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparisons. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizophrenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/bf02189022</identifier><identifier>PMID: 8908411</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Alleles ; Brain - enzymology ; Brain - physiopathology ; Female ; Genotype ; Humans ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Receptors, Dopamine D2 - physiology ; Schizophrenia - genetics ; Schizophrenia - physiopathology ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>European archives of psychiatry and clinical neuroscience, 1996, Vol.246 (6), p.297-304</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-b509531bed902f81b8293a1c7a88c822f8263d84a45928f26737cb200fcb446d3</citedby><cites>FETCH-LOGICAL-c434t-b509531bed902f81b8293a1c7a88c822f8263d84a45928f26737cb200fcb446d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8908411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1937405$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jönsson, E</creatorcontrib><creatorcontrib>Brené, S</creatorcontrib><creatorcontrib>Geijer, T</creatorcontrib><creatorcontrib>Terenius, L</creatorcontrib><creatorcontrib>Tylec, A</creatorcontrib><creatorcontrib>Persson, M L</creatorcontrib><creatorcontrib>Sedvall, G</creatorcontrib><title>A search for association between schizophrenia and dopamine-related alleles</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic patients and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparisons. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizophrenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Brain - enzymology</subject><subject>Brain - physiopathology</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Receptors, Dopamine D2 - physiology</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - physiopathology</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1Lw0AQxRdRaq1evAt78iBE9yvN5liLVbHgRc_LfkxoNM3G3YSif70pTevJ0wzD77038BC6pOSWEpLdmYIwKnPC2BEaU8F5IkVOj9GY5IIklHNxis5i_CCE0JSRERr1sBSUjtHLDEfQwa5w4QPWMXpb6rb0NTbQbgBqHO2q_PHNKkBdaqxrh51v9LqsIQlQ6RYc1lUFFcRzdFLoKsLFMCfoffHwNn9Klq-Pz_PZMrGCizYxKclTTg24_uNCUiNZzjW1mZbSStaf2JQ7KbRIcyYLNs14Zg0jpLBGiKnjE5TsfOMGms6oJpRrHb6V16UaTp_9BkrwXPZRE5T9yzfBuz_RXkhzngmyVV7vlD321UFs1bqMFqpK1-C7qDKZMpYK1oM3O9AGH2OA4hBCidp2pO4X-456-Gpw7cwa3AEdSuG_4DqMug</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Jönsson, E</creator><creator>Brené, S</creator><creator>Geijer, T</creator><creator>Terenius, L</creator><creator>Tylec, A</creator><creator>Persson, M L</creator><creator>Sedvall, G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>1996</creationdate><title>A search for association between schizophrenia and dopamine-related alleles</title><author>Jönsson, E ; Brené, S ; Geijer, T ; Terenius, L ; Tylec, A ; Persson, M L ; Sedvall, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-b509531bed902f81b8293a1c7a88c822f8263d84a45928f26737cb200fcb446d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Brain - enzymology</topic><topic>Brain - physiopathology</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Receptors, Dopamine D2 - physiology</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - physiopathology</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jönsson, E</creatorcontrib><creatorcontrib>Brené, S</creatorcontrib><creatorcontrib>Geijer, T</creatorcontrib><creatorcontrib>Terenius, L</creatorcontrib><creatorcontrib>Tylec, A</creatorcontrib><creatorcontrib>Persson, M L</creatorcontrib><creatorcontrib>Sedvall, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jönsson, E</au><au>Brené, S</au><au>Geijer, T</au><au>Terenius, L</au><au>Tylec, A</au><au>Persson, M L</au><au>Sedvall, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A search for association between schizophrenia and dopamine-related alleles</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><date>1996</date><risdate>1996</risdate><volume>246</volume><issue>6</issue><spage>297</spage><epage>304</epage><pages>297-304</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic patients and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparisons. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizophrenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.</abstract><cop>Germany</cop><pmid>8908411</pmid><doi>10.1007/bf02189022</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-1334 |
| ispartof | European archives of psychiatry and clinical neuroscience, 1996, Vol.246 (6), p.297-304 |
| issn | 0940-1334 1433-8491 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_439895 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Alleles Brain - enzymology Brain - physiopathology Female Genotype Humans Male Medicin och hälsovetenskap Middle Aged Receptors, Dopamine D2 - physiology Schizophrenia - genetics Schizophrenia - physiopathology Tyrosine 3-Monooxygenase - metabolism |
| title | A search for association between schizophrenia and dopamine-related alleles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T03%3A11%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20search%20for%20association%20between%20schizophrenia%20and%20dopamine-related%20alleles&rft.jtitle=European%20archives%20of%20psychiatry%20and%20clinical%20neuroscience&rft.au=J%C3%B6nsson,%20E&rft.date=1996&rft.volume=246&rft.issue=6&rft.spage=297&rft.epage=304&rft.pages=297-304&rft.issn=0940-1334&rft.eissn=1433-8491&rft_id=info:doi/10.1007/bf02189022&rft_dat=%3Cproquest_swepu%3E78522542%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78522542&rft_id=info:pmid/8908411&rfr_iscdi=true |