Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells

The effect of chronic treatment with the cholinesterase inhibitor tacrine on alpha 4 beta 2 nicotinic acetylcholine receptors (nAChRs) was investigated in a transfected fibroblast cell line, M10. Tacrine significantly increased (+46%; 5 x 10(-8) to 10(-5) M) and decreased (-74%; 2 x 10(-5) to 10(-4)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroreport 1996-09, Vol.7 (13), p.2201-2205
Hauptverfasser:	Svensson, A L, Nordberg, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - metabolism Allosteric Site Animals Azocines Cells, Cultured Chickens Cycloheximide - pharmacology Fibroblasts Gene Expression - drug effects Kinetics Macromolecular Substances Mecamylamine - pharmacology Mice Nicotine - pharmacology Quinolizines Receptors, Nicotinic - biosynthesis Receptors, Nicotinic - chemistry Receptors, Nicotinic - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - metabolism Tacrine - metabolism Tacrine - pharmacology Transfection Tubocurarine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!