Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae
1 Haartman Institute, Department of Virology, POB 21, FIN-00014 University of Helsinki, Finland 2 Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden 3 Regional Hygienic Institute of South Moravia, Brno, Czech Republic 4 Finnish Forest Research Institute, FIN-01301 Vantaa, F...
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| Veröffentlicht in: | Journal of general virology 1996-12, Vol.77 (12), p.3063-3067 |
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| container_title | Journal of general virology |
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| creator | Vapalahti, Olli Lundkvist, Ake Kukkonen, Sami K. J Cheng, Ying Gilljam, Mari Kanerva, Mari Manni, Tytti Pejcoch, Milan Niemimaa, Jukka Kaikusalo, Asko Henttonen, Heikki Vaheri, Antti Plyusnin, Alexander |
| description | 1 Haartman Institute, Department of Virology, POB 21, FIN-00014 University of Helsinki, Finland
2 Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden
3 Regional Hygienic Institute of South Moravia, Brno, Czech Republic
4 Finnish Forest Research Institute, FIN-01301 Vantaa, Finland
A Vero E6 cell culture isolate of Tula virus (TUL), a hantavirus first detected in European common voles ( Microtus arvalis and M. rossiaemeridionalis ) by RT-PCR was obtained after initial passaging of TUL-infected vole lung samples in laboratory-colonized M. arvalis . TUL was defined as a classical serotype by a cross-focus-reduction neutralization test (FRNT) and was also shown to be distinct from other hantaviruses by haemagglutination inhibition assay. The sequences of S, M and partial L genome segments of the isolate were determined: the S segment was 99·9% identical to the original rodent-derived sequence. Serological evidence for a previous TUL infection was obtained from the serum of a blood donor living near a TUL focus in Moravia, Czech Republic, showing at least a 16-fold higher FRNT titre to TUL as compared to Puumala or other hantaviruses.
Received 7 June 1996;
accepted 12 August 1996. |
| doi_str_mv | 10.1099/0022-1317-77-12-3063 |
| format | Article |
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2 Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden
3 Regional Hygienic Institute of South Moravia, Brno, Czech Republic
4 Finnish Forest Research Institute, FIN-01301 Vantaa, Finland
A Vero E6 cell culture isolate of Tula virus (TUL), a hantavirus first detected in European common voles ( Microtus arvalis and M. rossiaemeridionalis ) by RT-PCR was obtained after initial passaging of TUL-infected vole lung samples in laboratory-colonized M. arvalis . TUL was defined as a classical serotype by a cross-focus-reduction neutralization test (FRNT) and was also shown to be distinct from other hantaviruses by haemagglutination inhibition assay. The sequences of S, M and partial L genome segments of the isolate were determined: the S segment was 99·9% identical to the original rodent-derived sequence. Serological evidence for a previous TUL infection was obtained from the serum of a blood donor living near a TUL focus in Moravia, Czech Republic, showing at least a 16-fold higher FRNT titre to TUL as compared to Puumala or other hantaviruses.
Received 7 June 1996;
accepted 12 August 1996.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-77-12-3063</identifier><identifier>PMID: 9000098</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Animals ; Antibodies, Viral - blood ; Arvicolinae - virology ; Base Sequence ; Cercopithecus aethiops ; Hantavirus - genetics ; Hantavirus - immunology ; Hantavirus - isolation & purification ; Hantavirus Infections - immunology ; Hantavirus Infections - pathology ; Hantavirus Infections - virology ; Medicin och hälsovetenskap ; Microtus arvalis ; Molecular Sequence Data ; Rabbits ; RNA, Viral - analysis ; Serotyping ; Tula virus ; Vero Cells</subject><ispartof>Journal of general virology, 1996-12, Vol.77 (12), p.3063-3067</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-4d26cad2dfde232bb1a74dd32af07e0b119b0ad8946a71f86f02d2f006616c093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3746,3747,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9000098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:114286972$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Vapalahti, Olli</creatorcontrib><creatorcontrib>Lundkvist, Ake</creatorcontrib><creatorcontrib>Kukkonen, Sami K. J</creatorcontrib><creatorcontrib>Cheng, Ying</creatorcontrib><creatorcontrib>Gilljam, Mari</creatorcontrib><creatorcontrib>Kanerva, Mari</creatorcontrib><creatorcontrib>Manni, Tytti</creatorcontrib><creatorcontrib>Pejcoch, Milan</creatorcontrib><creatorcontrib>Niemimaa, Jukka</creatorcontrib><creatorcontrib>Kaikusalo, Asko</creatorcontrib><creatorcontrib>Henttonen, Heikki</creatorcontrib><creatorcontrib>Vaheri, Antti</creatorcontrib><creatorcontrib>Plyusnin, Alexander</creatorcontrib><title>Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>1 Haartman Institute, Department of Virology, POB 21, FIN-00014 University of Helsinki, Finland
2 Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden
3 Regional Hygienic Institute of South Moravia, Brno, Czech Republic
4 Finnish Forest Research Institute, FIN-01301 Vantaa, Finland
A Vero E6 cell culture isolate of Tula virus (TUL), a hantavirus first detected in European common voles ( Microtus arvalis and M. rossiaemeridionalis ) by RT-PCR was obtained after initial passaging of TUL-infected vole lung samples in laboratory-colonized M. arvalis . TUL was defined as a classical serotype by a cross-focus-reduction neutralization test (FRNT) and was also shown to be distinct from other hantaviruses by haemagglutination inhibition assay. The sequences of S, M and partial L genome segments of the isolate were determined: the S segment was 99·9% identical to the original rodent-derived sequence. Serological evidence for a previous TUL infection was obtained from the serum of a blood donor living near a TUL focus in Moravia, Czech Republic, showing at least a 16-fold higher FRNT titre to TUL as compared to Puumala or other hantaviruses.
Received 7 June 1996;
accepted 12 August 1996.</description><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Arvicolinae - virology</subject><subject>Base Sequence</subject><subject>Cercopithecus aethiops</subject><subject>Hantavirus - genetics</subject><subject>Hantavirus - immunology</subject><subject>Hantavirus - isolation & purification</subject><subject>Hantavirus Infections - immunology</subject><subject>Hantavirus Infections - pathology</subject><subject>Hantavirus Infections - virology</subject><subject>Medicin och hälsovetenskap</subject><subject>Microtus arvalis</subject><subject>Molecular Sequence Data</subject><subject>Rabbits</subject><subject>RNA, Viral - analysis</subject><subject>Serotyping</subject><subject>Tula virus</subject><subject>Vero Cells</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCPwDJJyQkAh7HseMjVNBWqsSlnK1JbHcN-VjshGr59ThKWLggfLE187wzlh5CXgB7C0zrd4xxXkAJqlCqAF6UTJaPyA6ErAqegcdkd0KekvOUvjIGQlTqjJxplo-ud2S4SWOHUxgHioOl7R4jtpOL4edaHD29mzukP0Kc0xuK1IY0haGdaHJxnI4HR8NAp72j926YE73GYcIN9tiH7kg_zMNxKQWL7hl54rFL7vl2X5Avnz7eXV4Xt5-vbi7f3xZtxWAqhOWyRcutt46XvGkAlbC25OiZcqwB0A1DW2shUYGvpWfccs-YlCBbpssLUqxz04M7zI05xNBjPJoRg9lK3_LLGVFqznjm9T_5Qxztn9DvIIDgtdRqyb5asxn8Prs0mT6k1nUdDm6ck1G1VAqU-C8IVV1VmtUZFCvYxjGl6PzpP8DM4t4sYs0i1ihlgJvFfY693ObPTe_sKbTJzv3Xa38f7vcPITqTnfUhL2nCaLKhv2b9Api-uvI</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Vapalahti, Olli</creator><creator>Lundkvist, Ake</creator><creator>Kukkonen, Sami K. 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J ; Cheng, Ying ; Gilljam, Mari ; Kanerva, Mari ; Manni, Tytti ; Pejcoch, Milan ; Niemimaa, Jukka ; Kaikusalo, Asko ; Henttonen, Heikki ; Vaheri, Antti ; Plyusnin, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-4d26cad2dfde232bb1a74dd32af07e0b119b0ad8946a71f86f02d2f006616c093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Arvicolinae - virology</topic><topic>Base Sequence</topic><topic>Cercopithecus aethiops</topic><topic>Hantavirus - genetics</topic><topic>Hantavirus - immunology</topic><topic>Hantavirus - isolation & purification</topic><topic>Hantavirus Infections - immunology</topic><topic>Hantavirus Infections - pathology</topic><topic>Hantavirus Infections - virology</topic><topic>Medicin och hälsovetenskap</topic><topic>Microtus arvalis</topic><topic>Molecular Sequence Data</topic><topic>Rabbits</topic><topic>RNA, Viral - analysis</topic><topic>Serotyping</topic><topic>Tula virus</topic><topic>Vero Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vapalahti, Olli</creatorcontrib><creatorcontrib>Lundkvist, Ake</creatorcontrib><creatorcontrib>Kukkonen, Sami K. 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J</au><au>Cheng, Ying</au><au>Gilljam, Mari</au><au>Kanerva, Mari</au><au>Manni, Tytti</au><au>Pejcoch, Milan</au><au>Niemimaa, Jukka</au><au>Kaikusalo, Asko</au><au>Henttonen, Heikki</au><au>Vaheri, Antti</au><au>Plyusnin, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>77</volume><issue>12</issue><spage>3063</spage><epage>3067</epage><pages>3063-3067</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>1 Haartman Institute, Department of Virology, POB 21, FIN-00014 University of Helsinki, Finland
2 Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden
3 Regional Hygienic Institute of South Moravia, Brno, Czech Republic
4 Finnish Forest Research Institute, FIN-01301 Vantaa, Finland
A Vero E6 cell culture isolate of Tula virus (TUL), a hantavirus first detected in European common voles ( Microtus arvalis and M. rossiaemeridionalis ) by RT-PCR was obtained after initial passaging of TUL-infected vole lung samples in laboratory-colonized M. arvalis . TUL was defined as a classical serotype by a cross-focus-reduction neutralization test (FRNT) and was also shown to be distinct from other hantaviruses by haemagglutination inhibition assay. The sequences of S, M and partial L genome segments of the isolate were determined: the S segment was 99·9% identical to the original rodent-derived sequence. Serological evidence for a previous TUL infection was obtained from the serum of a blood donor living near a TUL focus in Moravia, Czech Republic, showing at least a 16-fold higher FRNT titre to TUL as compared to Puumala or other hantaviruses.
Received 7 June 1996;
accepted 12 August 1996.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>9000098</pmid><doi>10.1099/0022-1317-77-12-3063</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of general virology, 1996-12, Vol.77 (12), p.3063-3067 |
| issn | 0022-1317 1465-2099 |
| language | eng |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antibodies, Viral - blood Arvicolinae - virology Base Sequence Cercopithecus aethiops Hantavirus - genetics Hantavirus - immunology Hantavirus - isolation & purification Hantavirus Infections - immunology Hantavirus Infections - pathology Hantavirus Infections - virology Medicin och hälsovetenskap Microtus arvalis Molecular Sequence Data Rabbits RNA, Viral - analysis Serotyping Tula virus Vero Cells |
| title | Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae |
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