Leishmania aethiopica Derived from Diffuse Leishmaniasis Patients Preferentially Induce mRNA for Interleukin-10 while Those from Localized Leishmaniasis Patients Induce Interferon-γ
Exposure of peripheral blood mononuclear cells to promastigotes of Leishmania aethiopica derived from patients with the self-limiting, localized form of the disease (local cutaneous leishmaniasis; LCL) preferentially induced mRNA for interferon (IFN)-³ but little for interleukin (IL)-IO. In contrast...
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| Veröffentlicht in: | The Journal of infectious diseases 1997-03, Vol.175 (3), p.737-741 |
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| creator | Akuffo, Hannah Maasho, Kerima Blostedt, Maine H±jeberg, Bo Britton, Sven Bakhiet, Moiz |
| description | Exposure of peripheral blood mononuclear cells to promastigotes of Leishmania aethiopica derived from patients with the self-limiting, localized form of the disease (local cutaneous leishmaniasis; LCL) preferentially induced mRNA for interferon (IFN)-³ but little for interleukin (IL)-IO. In contrast, stimulation of the same cells with promastigotes derived from patients with the persistent, disseminated form of the disease (diffuse cutaneous leishmaniasis; DCL) stimulated the expression of IL-10 rather than IFN-³. In general, parasites derived from LCL patients induced more expression of other cytokines tested, including IL-4, IL-6, and transforming growth factor-², although tumor necrosis factor-± was equivalent in cultures stimulated with LCL or DCL promastigotes. The results suggest that the antigen-specific immunosuppression observed in DCL patients and the resulting clinical picture could in part be due to the properties of the infecting parasite to induce more IL10 than IFN-³. |
| doi_str_mv | 10.1093/infdis/175.3.737 |
| format | Article |
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In contrast, stimulation of the same cells with promastigotes derived from patients with the persistent, disseminated form of the disease (diffuse cutaneous leishmaniasis; DCL) stimulated the expression of IL-10 rather than IFN-³. In general, parasites derived from LCL patients induced more expression of other cytokines tested, including IL-4, IL-6, and transforming growth factor-², although tumor necrosis factor-± was equivalent in cultures stimulated with LCL or DCL promastigotes. The results suggest that the antigen-specific immunosuppression observed in DCL patients and the resulting clinical picture could in part be due to the properties of the infecting parasite to induce more IL10 than IFN-³.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/175.3.737</identifier><identifier>PMID: 9041358</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Animals ; Antigens ; Biological and medical sciences ; Cells, Cultured ; Concise Communications ; Cytokines ; Gene Expression ; Human protozoal diseases ; Humans ; In Situ Hybridization ; Infections ; Infectious diseases ; Interferon-gamma - genetics ; Interleukin-10 - genetics ; Leishmania - immunology ; Leishmaniasis ; Leishmaniasis, Cutaneous - genetics ; Leishmaniasis, Cutaneous - immunology ; Leishmaniasis, Cutaneous - pathology ; Leshmaniasis ; Lesions ; Medical sciences ; Medicin och hälsovetenskap ; Messenger RNA ; Natural killer cells ; Parasites ; Parasitic diseases ; Promastigotes ; Protozoal diseases ; RNA, Messenger - genetics ; T lymphocytes ; Time Factors ; Tropical medicine</subject><ispartof>The Journal of infectious diseases, 1997-03, Vol.175 (3), p.737-741</ispartof><rights>Copyright 1997 The University of Chicago</rights><rights>1997 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Mar 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30130069$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30130069$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2612614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9041358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1940255$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Akuffo, Hannah</creatorcontrib><creatorcontrib>Maasho, Kerima</creatorcontrib><creatorcontrib>Blostedt, Maine</creatorcontrib><creatorcontrib>H±jeberg, Bo</creatorcontrib><creatorcontrib>Britton, Sven</creatorcontrib><creatorcontrib>Bakhiet, Moiz</creatorcontrib><title>Leishmania aethiopica Derived from Diffuse Leishmaniasis Patients Preferentially Induce mRNA for Interleukin-10 while Those from Localized Leishmaniasis Patients Induce Interferon-γ</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Exposure of peripheral blood mononuclear cells to promastigotes of Leishmania aethiopica derived from patients with the self-limiting, localized form of the disease (local cutaneous leishmaniasis; LCL) preferentially induced mRNA for interferon (IFN)-³ but little for interleukin (IL)-IO. In contrast, stimulation of the same cells with promastigotes derived from patients with the persistent, disseminated form of the disease (diffuse cutaneous leishmaniasis; DCL) stimulated the expression of IL-10 rather than IFN-³. In general, parasites derived from LCL patients induced more expression of other cytokines tested, including IL-4, IL-6, and transforming growth factor-², although tumor necrosis factor-± was equivalent in cultures stimulated with LCL or DCL promastigotes. The results suggest that the antigen-specific immunosuppression observed in DCL patients and the resulting clinical picture could in part be due to the properties of the infecting parasite to induce more IL10 than IFN-³.</description><subject>Animals</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Concise Communications</subject><subject>Cytokines</subject><subject>Gene Expression</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin-10 - genetics</subject><subject>Leishmania - immunology</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis, Cutaneous - genetics</subject><subject>Leishmaniasis, Cutaneous - immunology</subject><subject>Leishmaniasis, Cutaneous - pathology</subject><subject>Leshmaniasis</subject><subject>Lesions</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Messenger RNA</subject><subject>Natural killer cells</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Promastigotes</subject><subject>Protozoal diseases</subject><subject>RNA, Messenger - genetics</subject><subject>T lymphocytes</subject><subject>Time Factors</subject><subject>Tropical medicine</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEKqVw54JkIcQt25nYie1j1fKn0goQKufIm4y13ibxYietymsh8Rg8E9Y27EpIFQfLM57f9401dpa9RFggaH7qBtu6eIqyXPCF5PJRdowll3lVIX-cHQMURY5K66fZsxg3ACB4JY-yIw0CeamOs19LcnHdm8EZZmhcO791jWEXFNwNtcwG37MLZ-0UiR3Q6CL7YkZHw5iCQJZCCp3pujt2ObRTQ6z_-umMWR9SPlLoaLp2Q47AbteuI3a19slw5770jencj9TsAf_ZcOeTGvkh__3zefbEmi7Si3k_yb69f3d1_jFffv5weX62zDcCcMwNEShpsKhK0arGVByx4WAVWtC2xbRAUCtJl4UUFqSsZIG0qoRutUHgJ1l-7xtvaTut6m1wvQl3tTeuno-uU0S14ErvePkgvw2-PYj-ClELKMoyKd_eKxP2faI41r2LDXWdGchPsZZKFSUo-C-IpUatlEjg63_AjZ_CkMZVFwVPkOAyQa9maFr11O4vPH-QVH8z101M72SDGRoX91hRpdmiONhs4ujDvswBOUCl-R8kD9kL</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Akuffo, Hannah</creator><creator>Maasho, Kerima</creator><creator>Blostedt, Maine</creator><creator>H±jeberg, Bo</creator><creator>Britton, Sven</creator><creator>Bakhiet, Moiz</creator><general>University of Chicago Press</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19970301</creationdate><title>Leishmania aethiopica Derived from Diffuse Leishmaniasis Patients Preferentially Induce mRNA for Interleukin-10 while Those from Localized Leishmaniasis Patients Induce Interferon-γ</title><author>Akuffo, Hannah ; Maasho, Kerima ; Blostedt, Maine ; H±jeberg, Bo ; Britton, Sven ; Bakhiet, Moiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j401t-aee087a12654d8ca6311c30f81f09fd19fd04ed7e95274f0776721eb649d9a103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Concise Communications</topic><topic>Cytokines</topic><topic>Gene Expression</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-10 - genetics</topic><topic>Leishmania - immunology</topic><topic>Leishmaniasis</topic><topic>Leishmaniasis, Cutaneous - genetics</topic><topic>Leishmaniasis, Cutaneous - immunology</topic><topic>Leishmaniasis, Cutaneous - pathology</topic><topic>Leshmaniasis</topic><topic>Lesions</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Messenger RNA</topic><topic>Natural killer cells</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Promastigotes</topic><topic>Protozoal diseases</topic><topic>RNA, Messenger - genetics</topic><topic>T lymphocytes</topic><topic>Time Factors</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akuffo, Hannah</creatorcontrib><creatorcontrib>Maasho, Kerima</creatorcontrib><creatorcontrib>Blostedt, Maine</creatorcontrib><creatorcontrib>H±jeberg, Bo</creatorcontrib><creatorcontrib>Britton, Sven</creatorcontrib><creatorcontrib>Bakhiet, Moiz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akuffo, Hannah</au><au>Maasho, Kerima</au><au>Blostedt, Maine</au><au>H±jeberg, Bo</au><au>Britton, Sven</au><au>Bakhiet, Moiz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leishmania aethiopica Derived from Diffuse Leishmaniasis Patients Preferentially Induce mRNA for Interleukin-10 while Those from Localized Leishmaniasis Patients Induce Interferon-γ</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>175</volume><issue>3</issue><spage>737</spage><epage>741</epage><pages>737-741</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Exposure of peripheral blood mononuclear cells to promastigotes of Leishmania aethiopica derived from patients with the self-limiting, localized form of the disease (local cutaneous leishmaniasis; LCL) preferentially induced mRNA for interferon (IFN)-³ but little for interleukin (IL)-IO. In contrast, stimulation of the same cells with promastigotes derived from patients with the persistent, disseminated form of the disease (diffuse cutaneous leishmaniasis; DCL) stimulated the expression of IL-10 rather than IFN-³. In general, parasites derived from LCL patients induced more expression of other cytokines tested, including IL-4, IL-6, and transforming growth factor-², although tumor necrosis factor-± was equivalent in cultures stimulated with LCL or DCL promastigotes. The results suggest that the antigen-specific immunosuppression observed in DCL patients and the resulting clinical picture could in part be due to the properties of the infecting parasite to induce more IL10 than IFN-³.</abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>9041358</pmid><doi>10.1093/infdis/175.3.737</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Antigens Biological and medical sciences Cells, Cultured Concise Communications Cytokines Gene Expression Human protozoal diseases Humans In Situ Hybridization Infections Infectious diseases Interferon-gamma - genetics Interleukin-10 - genetics Leishmania - immunology Leishmaniasis Leishmaniasis, Cutaneous - genetics Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - pathology Leshmaniasis Lesions Medical sciences Medicin och hälsovetenskap Messenger RNA Natural killer cells Parasites Parasitic diseases Promastigotes Protozoal diseases RNA, Messenger - genetics T lymphocytes Time Factors Tropical medicine |
| title | Leishmania aethiopica Derived from Diffuse Leishmaniasis Patients Preferentially Induce mRNA for Interleukin-10 while Those from Localized Leishmaniasis Patients Induce Interferon-γ |
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