Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats
The role of cytochrome P450 metabolism of fatty acids and lipid peroxidation in the alterations of the fatty acid composition of the liver and liver pathology was investigated. The CYP2E1 inhibitors partially prevented CYP2E1 induction by ethanol and completely blocked lipid peroxidation. However, t...
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| Veröffentlicht in: | The Journal of nutrition 1997-05, Vol.127 (5 Suppl), p.907S-911S |
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| container_issue | 5 Suppl |
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| container_title | The Journal of nutrition |
| container_volume | 127 |
| creator | French, S W Morimoto, M Reitz, R C Koop, D Klopfenstein, B Estes, K Clot, P Ingelman-Sundberg, M Albano, E |
| description | The role of cytochrome P450 metabolism of fatty acids and lipid peroxidation in the alterations of the fatty acid composition of the liver and liver pathology was investigated. The CYP2E1 inhibitors partially prevented CYP2E1 induction by ethanol and completely blocked lipid peroxidation. However, the liver pathology induced by ethanol was only partially prevented as was the decrease in arachidonic acid in total liver lipid, triglycerides and cholesterol esters. This means that liver peroxidation induced by ethanol can not completely account for the liver pathology or the decrease in arachidonic acid caused by ethanol. Lauric acid omega-1 hydroxidation by the liver microsomes in vitro was increased by ethanol and partially blocked by CYP2E1 inhibitors. However, although ethanol feeding increased the total hydroxidation and epoxidation of arachidonic acid, these were not inhibited by CYP2E1 inhibitors. Thus the ethanol-induced arachidonic acid depletion is not likely due to CYP2E1 metabolism of arachidonic acid, since the severity of liver pathology correlated negatively with the decrease in arachidonic acid in the ethanol-fed rats. The increase in its metabolism by microsomes and decrease in synthesis may be an important mechanism of ethanol-induced liver injury. |
| doi_str_mv | 10.1093/jn/127.5.907S |
| format | Article |
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The CYP2E1 inhibitors partially prevented CYP2E1 induction by ethanol and completely blocked lipid peroxidation. However, the liver pathology induced by ethanol was only partially prevented as was the decrease in arachidonic acid in total liver lipid, triglycerides and cholesterol esters. This means that liver peroxidation induced by ethanol can not completely account for the liver pathology or the decrease in arachidonic acid caused by ethanol. Lauric acid omega-1 hydroxidation by the liver microsomes in vitro was increased by ethanol and partially blocked by CYP2E1 inhibitors. However, although ethanol feeding increased the total hydroxidation and epoxidation of arachidonic acid, these were not inhibited by CYP2E1 inhibitors. Thus the ethanol-induced arachidonic acid depletion is not likely due to CYP2E1 metabolism of arachidonic acid, since the severity of liver pathology correlated negatively with the decrease in arachidonic acid in the ethanol-fed rats. The increase in its metabolism by microsomes and decrease in synthesis may be an important mechanism of ethanol-induced liver injury.</description><identifier>ISSN: 0022-3166</identifier><identifier>DOI: 10.1093/jn/127.5.907S</identifier><identifier>PMID: 9164261</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arachidonic Acid - metabolism ; Cholesterol Esters - metabolism ; Cytochrome P-450 CYP2E1 - metabolism ; Ethanol - administration & dosage ; Ethanol - pharmacology ; Fatty Acids - metabolism ; Lipid Peroxidation ; Liver - metabolism ; Liver Diseases, Alcoholic - metabolism ; Male ; Medicin och hälsovetenskap ; Microsomes, Liver - enzymology ; Rats ; Rats, Wistar</subject><ispartof>The Journal of nutrition, 1997-05, Vol.127 (5 Suppl), p.907S-911S</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-4ccbc2ff6e2eb18f9d9b5bfedd0c459b12d1847f9c8eba6ef96814098d325c483</citedby><cites>FETCH-LOGICAL-c483t-4ccbc2ff6e2eb18f9d9b5bfedd0c459b12d1847f9c8eba6ef96814098d325c483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,309,310,314,552,780,784,789,790,885,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9164261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1941552$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>French, S W</creatorcontrib><creatorcontrib>Morimoto, M</creatorcontrib><creatorcontrib>Reitz, R C</creatorcontrib><creatorcontrib>Koop, D</creatorcontrib><creatorcontrib>Klopfenstein, B</creatorcontrib><creatorcontrib>Estes, K</creatorcontrib><creatorcontrib>Clot, P</creatorcontrib><creatorcontrib>Ingelman-Sundberg, M</creatorcontrib><creatorcontrib>Albano, E</creatorcontrib><title>Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The role of cytochrome P450 metabolism of fatty acids and lipid peroxidation in the alterations of the fatty acid composition of the liver and liver pathology was investigated. The CYP2E1 inhibitors partially prevented CYP2E1 induction by ethanol and completely blocked lipid peroxidation. However, the liver pathology induced by ethanol was only partially prevented as was the decrease in arachidonic acid in total liver lipid, triglycerides and cholesterol esters. This means that liver peroxidation induced by ethanol can not completely account for the liver pathology or the decrease in arachidonic acid caused by ethanol. Lauric acid omega-1 hydroxidation by the liver microsomes in vitro was increased by ethanol and partially blocked by CYP2E1 inhibitors. However, although ethanol feeding increased the total hydroxidation and epoxidation of arachidonic acid, these were not inhibited by CYP2E1 inhibitors. Thus the ethanol-induced arachidonic acid depletion is not likely due to CYP2E1 metabolism of arachidonic acid, since the severity of liver pathology correlated negatively with the decrease in arachidonic acid in the ethanol-fed rats. The increase in its metabolism by microsomes and decrease in synthesis may be an important mechanism of ethanol-induced liver injury.</description><subject>Animals</subject><subject>Arachidonic Acid - metabolism</subject><subject>Cholesterol Esters - metabolism</subject><subject>Cytochrome P-450 CYP2E1 - metabolism</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - pharmacology</subject><subject>Fatty Acids - metabolism</subject><subject>Lipid Peroxidation</subject><subject>Liver - metabolism</subject><subject>Liver Diseases, Alcoholic - metabolism</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Microsomes, Liver - enzymology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0022-3166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kTtPwzAUhT2ASimMjEj-AaS1HSexR1SVh1QJJGBgQJafqksaR3Z4_XsStbQT031959zhAHCB0RQjns_WzQyTalpMOaqejsAYIUKyHJflCThNaY0QwpSzERhxXFJS4jF4W_rWG9jaGL69kZ0PzRWcvz6SBYayMVBGqVfehMZrKHVPbmwnVah92kDfQFnrsOonDWv_aSM0PlmZ7HCKsktn4NjJOtnzXZ2Al5vF8_wuWz7c3s-vl5mmLO8yqrXSxLnSEqswc9xwVShnjUGaFlxhYjCjleOaWSVL63jJMEWcmZwUg8UEZFvf9GXbDyXa6Dcy_oggvdit3vvOCpozhHnPV__ybQzmIPoTYk5xUZDDJx1DStG6vRYjMWQg1o3oMxCFGDLo-cst39ttrNnTuwDyX21RhyU</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>French, S W</creator><creator>Morimoto, M</creator><creator>Reitz, R C</creator><creator>Koop, D</creator><creator>Klopfenstein, B</creator><creator>Estes, K</creator><creator>Clot, P</creator><creator>Ingelman-Sundberg, M</creator><creator>Albano, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><scope>BNKNJ</scope><scope>BVBDO</scope></search><sort><creationdate>19970501</creationdate><title>Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats</title><author>French, S W ; Morimoto, M ; Reitz, R C ; Koop, D ; Klopfenstein, B ; Estes, K ; Clot, P ; Ingelman-Sundberg, M ; Albano, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-4ccbc2ff6e2eb18f9d9b5bfedd0c459b12d1847f9c8eba6ef96814098d325c483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Arachidonic Acid - metabolism</topic><topic>Cholesterol Esters - metabolism</topic><topic>Cytochrome P-450 CYP2E1 - metabolism</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - pharmacology</topic><topic>Fatty Acids - metabolism</topic><topic>Lipid Peroxidation</topic><topic>Liver - metabolism</topic><topic>Liver Diseases, Alcoholic - metabolism</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Microsomes, Liver - enzymology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>French, S W</creatorcontrib><creatorcontrib>Morimoto, M</creatorcontrib><creatorcontrib>Reitz, R C</creatorcontrib><creatorcontrib>Koop, D</creatorcontrib><creatorcontrib>Klopfenstein, B</creatorcontrib><creatorcontrib>Estes, K</creatorcontrib><creatorcontrib>Clot, P</creatorcontrib><creatorcontrib>Ingelman-Sundberg, M</creatorcontrib><creatorcontrib>Albano, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><collection>SwePub Conference</collection><collection>SwePub Conference full text</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>French, S W</au><au>Morimoto, M</au><au>Reitz, R C</au><au>Koop, D</au><au>Klopfenstein, B</au><au>Estes, K</au><au>Clot, P</au><au>Ingelman-Sundberg, M</au><au>Albano, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>127</volume><issue>5 Suppl</issue><spage>907S</spage><epage>911S</epage><pages>907S-911S</pages><issn>0022-3166</issn><abstract>The role of cytochrome P450 metabolism of fatty acids and lipid peroxidation in the alterations of the fatty acid composition of the liver and liver pathology was investigated. The CYP2E1 inhibitors partially prevented CYP2E1 induction by ethanol and completely blocked lipid peroxidation. However, the liver pathology induced by ethanol was only partially prevented as was the decrease in arachidonic acid in total liver lipid, triglycerides and cholesterol esters. This means that liver peroxidation induced by ethanol can not completely account for the liver pathology or the decrease in arachidonic acid caused by ethanol. Lauric acid omega-1 hydroxidation by the liver microsomes in vitro was increased by ethanol and partially blocked by CYP2E1 inhibitors. However, although ethanol feeding increased the total hydroxidation and epoxidation of arachidonic acid, these were not inhibited by CYP2E1 inhibitors. Thus the ethanol-induced arachidonic acid depletion is not likely due to CYP2E1 metabolism of arachidonic acid, since the severity of liver pathology correlated negatively with the decrease in arachidonic acid in the ethanol-fed rats. The increase in its metabolism by microsomes and decrease in synthesis may be an important mechanism of ethanol-induced liver injury.</abstract><cop>United States</cop><pmid>9164261</pmid><doi>10.1093/jn/127.5.907S</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Alma/SFX Local Collection |
| subjects | Animals Arachidonic Acid - metabolism Cholesterol Esters - metabolism Cytochrome P-450 CYP2E1 - metabolism Ethanol - administration & dosage Ethanol - pharmacology Fatty Acids - metabolism Lipid Peroxidation Liver - metabolism Liver Diseases, Alcoholic - metabolism Male Medicin och hälsovetenskap Microsomes, Liver - enzymology Rats Rats, Wistar |
| title | Lipid peroxidation, CYP2E1 and arachidonic acid metabolism in alcoholic liver disease in rats |
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