Intratumoral infusion of the monoclonal antibody, mAb 425, against the epidermal-growth-factor receptor in patients with advanced malignant glioma

Malignant glioblastoma may over-express the epidermal-growth-factor receptor (EGF-R). Normal brain cells show a low or no expression of EGF-R. A mouse monoclonal antibody (IgG2A) (mAb 425) (EMD55900) (Merck KGaA, Bernstadt, Germany) directed against EGF-R was produced for therapeutic use. Eight pati...

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Veröffentlicht in:	CANCER IMMUNOLOGY, IMMUNOTHERAPY IMMUNOTHERAPY, 1997-05, Vol.44 (3), p.157-164
Hauptverfasser:	WERSÄLL, P, OHLSSON, I, BIBERFELD, P, COLLINS, V. P, VON KRUSENSTJERNA, S, LARSSON, S, MELLSTEDT, H, BOETHIUS, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibodies, Monoclonal - administration & dosage Antineoplastic agents Biological and medical sciences ErbB Receptors - immunology Female Glioblastoma - drug therapy Glioblastoma - immunology Glioblastoma - pathology Humans Immunotherapy Injections, Intralesional Male Medical sciences Medicin och hälsovetenskap Mice Middle Aged Original Pharmacology. Drug treatments Recurrence
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