How does interferon exert its cell growth inhibitory effect?
: The interferons (IFNs) have become accepted therapy in a range of haematological and non‐haematological malignancies. The mechanism behind IFN's antitumour action is, however, unclear. Interferons (IFNs) are capable of modulating a variety of cellular responses. One prominent effect of IFNs i...
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| Veröffentlicht in: | European journal of haematology 1997-09, Vol.59 (3), p.129-135 |
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| container_title | European journal of haematology |
| container_volume | 59 |
| creator | Grandér, Dan Sangfelt, Olle Erickson, Sven |
| description | : The interferons (IFNs) have become accepted therapy in a range of haematological and non‐haematological malignancies. The mechanism behind IFN's antitumour action is, however, unclear. Interferons (IFNs) are capable of modulating a variety of cellular responses. One prominent effect of IFNs is their cell growth inhibitory activity, which has also been suggested to be of major importance in their antitumour action. In the present review we will discuss the cellular events leading to a decreased number of cells following IFN treatment, the molecular mechanisms underlying these phenomena, and the importance of these effects in a clinical perspective. |
| doi_str_mv | 10.1111/j.1600-0609.1997.tb00965.x |
| format | Article |
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The mechanism behind IFN's antitumour action is, however, unclear. Interferons (IFNs) are capable of modulating a variety of cellular responses. One prominent effect of IFNs is their cell growth inhibitory activity, which has also been suggested to be of major importance in their antitumour action. In the present review we will discuss the cellular events leading to a decreased number of cells following IFN treatment, the molecular mechanisms underlying these phenomena, and the importance of these effects in a clinical perspective.</description><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Cycle - physiology</subject><subject>Cell Cycle Proteins - drug effects</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Division - drug effects</subject><subject>cyclin-dependent kinase inhibitors</subject><subject>Eukaryotic Cells - physiology</subject><subject>Gene Expression Regulation</subject><subject>Immunotherapy</subject><subject>interferon</subject><subject>Interferons - pharmacology</subject><subject>Interferons - physiology</subject><subject>Medical sciences</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0902-4441 |
| ispartof | European journal of haematology, 1997-09, Vol.59 (3), p.129-135 |
| issn | 0902-4441 1600-0609 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antineoplastic agents Apoptosis Biological and medical sciences cell cycle Cell Cycle - drug effects Cell Cycle - physiology Cell Cycle Proteins - drug effects Cell Cycle Proteins - genetics Cell Division - drug effects cyclin-dependent kinase inhibitors Eukaryotic Cells - physiology Gene Expression Regulation Immunotherapy interferon Interferons - pharmacology Interferons - physiology Medical sciences Pharmacology. Drug treatments |
| title | How does interferon exert its cell growth inhibitory effect? |
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