Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins
HYPOTHERMIA applied after hypoxia offers neuroprotection in neonatal animals, but the mechanisms involved remain unknown. Hypoxia was induced in newborn piglets and changes in excitatory amino acids (EAAs) and the citrulline:arginine ratio (CAR) were followed by microdialysis for 5 h. After the 45 m...
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| Veröffentlicht in: | Neuroreport 1997-10, Vol.8 (15), p.3359-3362 |
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| creator | Thoresen, Marianne Satas, Saulius Puka-Sundvall, Malgorzata Whitelaw, Andrew Hallström, Åse Løberg, Else-Marit Ungerstedt, Urban Steen, Petter Andreas Hagberg, Henrik |
| description | HYPOTHERMIA applied after hypoxia offers neuroprotection in neonatal animals, but the mechanisms involved remain unknown. Hypoxia was induced in newborn piglets and changes in excitatory amino acids (EAAs) and the citrulline:arginine ratio (CAR) were followed by microdialysis for 5 h. After the 45 min hypoxic insult, the animals were randomized to receive normothermia (39°C; n = 7) or hypothermia (35°C; n = 7). After reoxygenation, extracellular glutamate, aspartate and the excitotoxic index were significantly lower in the cerebral cortex of hypothermic animals than in normothermic animals. A progressive rise of the CAR occurred during reoxygenation in the normothermic group whereas the ratio tended to decrease in the hypothermic group. In conclusion, post-hypoxic hypothermia attenuated NO production and overflow of EAAs. |
| doi_str_mv | 10.1097/00001756-199710200-00033 |
| format | Article |
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Hypoxia was induced in newborn piglets and changes in excitatory amino acids (EAAs) and the citrulline:arginine ratio (CAR) were followed by microdialysis for 5 h. After the 45 min hypoxic insult, the animals were randomized to receive normothermia (39°C; n = 7) or hypothermia (35°C; n = 7). After reoxygenation, extracellular glutamate, aspartate and the excitotoxic index were significantly lower in the cerebral cortex of hypothermic animals than in normothermic animals. A progressive rise of the CAR occurred during reoxygenation in the normothermic group whereas the ratio tended to decrease in the hypothermic group. In conclusion, post-hypoxic hypothermia attenuated NO production and overflow of EAAs.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199710200-00033</identifier><identifier>PMID: 9351672</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Arginine - metabolism ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Cerebral Cortex - metabolism ; Citrulline - metabolism ; Electroencephalography ; Excitatory Amino Acids - metabolism ; Fundamental and applied biological sciences. Psychology ; Hypothermia - metabolism ; Hypoxia, Brain - metabolism ; Medicin och hälsovetenskap ; Microdialysis ; Nitric Oxide - metabolism ; Swine ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1997-10, Vol.8 (15), p.3359-3362</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5013-21f1bad6738f2842c92bc9e0742d4d927c7699c916664f8cf4fe5828b0041bfc3</citedby><cites>FETCH-LOGICAL-c5013-21f1bad6738f2842c92bc9e0742d4d927c7699c916664f8cf4fe5828b0041bfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2847286$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9351672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1958451$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Thoresen, Marianne</creatorcontrib><creatorcontrib>Satas, Saulius</creatorcontrib><creatorcontrib>Puka-Sundvall, Malgorzata</creatorcontrib><creatorcontrib>Whitelaw, Andrew</creatorcontrib><creatorcontrib>Hallström, Åse</creatorcontrib><creatorcontrib>Løberg, Else-Marit</creatorcontrib><creatorcontrib>Ungerstedt, Urban</creatorcontrib><creatorcontrib>Steen, Petter Andreas</creatorcontrib><creatorcontrib>Hagberg, Henrik</creatorcontrib><title>Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>HYPOTHERMIA applied after hypoxia offers neuroprotection in neonatal animals, but the mechanisms involved remain unknown. Hypoxia was induced in newborn piglets and changes in excitatory amino acids (EAAs) and the citrulline:arginine ratio (CAR) were followed by microdialysis for 5 h. After the 45 min hypoxic insult, the animals were randomized to receive normothermia (39°C; n = 7) or hypothermia (35°C; n = 7). After reoxygenation, extracellular glutamate, aspartate and the excitotoxic index were significantly lower in the cerebral cortex of hypothermic animals than in normothermic animals. A progressive rise of the CAR occurred during reoxygenation in the normothermic group whereas the ratio tended to decrease in the hypothermic group. In conclusion, post-hypoxic hypothermia attenuated NO production and overflow of EAAs.</description><subject>Animals</subject><subject>Arginine - metabolism</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - metabolism</subject><subject>Citrulline - metabolism</subject><subject>Electroencephalography</subject><subject>Excitatory Amino Acids - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothermia - metabolism</subject><subject>Hypoxia, Brain - metabolism</subject><subject>Medicin och hälsovetenskap</subject><subject>Microdialysis</subject><subject>Nitric Oxide - metabolism</subject><subject>Swine</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1vEzEQhq0KVELoT0DaA-Jm8PfHEVWUVqoIBypxs7zesbJ0Ewd7V2n_PU6zDacKHzzWzPOOR36NUEPJJ0qs_kzqoloqTK3VlDBCcM1wfoYWVGiOpTS_XqEFsdJiYZV8g96W8rsillBzjs4tl1RptkCrH6mMeP24Sw99aA5xXEPe9L7J0E0BShMgQ5tTSHnsgx9qfgBfoEmx-b5q_LZr4CH0Yxprh215h15HPxS4mOMS3V19_Xl5jW9X324uv9ziIAnlmNFIW98pzU1kRrBgWRssEC1YJzrLdNDK2mCpUkpEE6KIIA0zLSGCtjHwJcLHvmUPu6l1u9xvfH50yfduTt3XEzjBlWK08vpFfpdT90_0LKRWGiEPyo9HZcX-TFBGt-lLgGHwW0hTcdpyZbjW_wWp4oTpui-ROYIhp1IyxNM0lLiDve7ZXney1z3ZW6Xv5zumdgPdSTj7Wesf5rov1ayY_Tb05YTVp9bMHCYQR2yfhhFyuR-mPWS3Bj-Ma_fS5-J_AbLKvgM</recordid><startdate>19971020</startdate><enddate>19971020</enddate><creator>Thoresen, Marianne</creator><creator>Satas, Saulius</creator><creator>Puka-Sundvall, Malgorzata</creator><creator>Whitelaw, Andrew</creator><creator>Hallström, Åse</creator><creator>Løberg, Else-Marit</creator><creator>Ungerstedt, Urban</creator><creator>Steen, Petter Andreas</creator><creator>Hagberg, Henrik</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19971020</creationdate><title>Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins</title><author>Thoresen, Marianne ; Satas, Saulius ; Puka-Sundvall, Malgorzata ; Whitelaw, Andrew ; Hallström, Åse ; Løberg, Else-Marit ; Ungerstedt, Urban ; Steen, Petter Andreas ; Hagberg, Henrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5013-21f1bad6738f2842c92bc9e0742d4d927c7699c916664f8cf4fe5828b0041bfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Arginine - metabolism</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - metabolism</topic><topic>Citrulline - metabolism</topic><topic>Electroencephalography</topic><topic>Excitatory Amino Acids - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothermia - metabolism</topic><topic>Hypoxia, Brain - metabolism</topic><topic>Medicin och hälsovetenskap</topic><topic>Microdialysis</topic><topic>Nitric Oxide - metabolism</topic><topic>Swine</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thoresen, Marianne</creatorcontrib><creatorcontrib>Satas, Saulius</creatorcontrib><creatorcontrib>Puka-Sundvall, Malgorzata</creatorcontrib><creatorcontrib>Whitelaw, Andrew</creatorcontrib><creatorcontrib>Hallström, Åse</creatorcontrib><creatorcontrib>Løberg, Else-Marit</creatorcontrib><creatorcontrib>Ungerstedt, Urban</creatorcontrib><creatorcontrib>Steen, Petter Andreas</creatorcontrib><creatorcontrib>Hagberg, Henrik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thoresen, Marianne</au><au>Satas, Saulius</au><au>Puka-Sundvall, Malgorzata</au><au>Whitelaw, Andrew</au><au>Hallström, Åse</au><au>Løberg, Else-Marit</au><au>Ungerstedt, Urban</au><au>Steen, Petter Andreas</au><au>Hagberg, Henrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1997-10-20</date><risdate>1997</risdate><volume>8</volume><issue>15</issue><spage>3359</spage><epage>3362</epage><pages>3359-3362</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>HYPOTHERMIA applied after hypoxia offers neuroprotection in neonatal animals, but the mechanisms involved remain unknown. Hypoxia was induced in newborn piglets and changes in excitatory amino acids (EAAs) and the citrulline:arginine ratio (CAR) were followed by microdialysis for 5 h. After the 45 min hypoxic insult, the animals were randomized to receive normothermia (39°C; n = 7) or hypothermia (35°C; n = 7). After reoxygenation, extracellular glutamate, aspartate and the excitotoxic index were significantly lower in the cerebral cortex of hypothermic animals than in normothermic animals. A progressive rise of the CAR occurred during reoxygenation in the normothermic group whereas the ratio tended to decrease in the hypothermic group. In conclusion, post-hypoxic hypothermia attenuated NO production and overflow of EAAs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9351672</pmid><doi>10.1097/00001756-199710200-00033</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroreport, 1997-10, Vol.8 (15), p.3359-3362 |
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| subjects | Animals Arginine - metabolism Biochemistry and metabolism Biological and medical sciences Central nervous system Cerebral Cortex - metabolism Citrulline - metabolism Electroencephalography Excitatory Amino Acids - metabolism Fundamental and applied biological sciences. Psychology Hypothermia - metabolism Hypoxia, Brain - metabolism Medicin och hälsovetenskap Microdialysis Nitric Oxide - metabolism Swine Vertebrates: nervous system and sense organs |
| title | Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins |
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