Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins

HYPOTHERMIA applied after hypoxia offers neuroprotection in neonatal animals, but the mechanisms involved remain unknown. Hypoxia was induced in newborn piglets and changes in excitatory amino acids (EAAs) and the citrulline:arginine ratio (CAR) were followed by microdialysis for 5 h. After the 45 m...

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Veröffentlicht in:Neuroreport 1997-10, Vol.8 (15), p.3359-3362
Hauptverfasser: Thoresen, Marianne, Satas, Saulius, Puka-Sundvall, Malgorzata, Whitelaw, Andrew, Hallström, Åse, Løberg, Else-Marit, Ungerstedt, Urban, Steen, Petter Andreas, Hagberg, Henrik
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container_end_page 3362
container_issue 15
container_start_page 3359
container_title Neuroreport
container_volume 8
creator Thoresen, Marianne
Satas, Saulius
Puka-Sundvall, Malgorzata
Whitelaw, Andrew
Hallström, Åse
Løberg, Else-Marit
Ungerstedt, Urban
Steen, Petter Andreas
Hagberg, Henrik
description HYPOTHERMIA applied after hypoxia offers neuroprotection in neonatal animals, but the mechanisms involved remain unknown. Hypoxia was induced in newborn piglets and changes in excitatory amino acids (EAAs) and the citrulline:arginine ratio (CAR) were followed by microdialysis for 5 h. After the 45 min hypoxic insult, the animals were randomized to receive normothermia (39°C; n = 7) or hypothermia (35°C; n = 7). After reoxygenation, extracellular glutamate, aspartate and the excitotoxic index were significantly lower in the cerebral cortex of hypothermic animals than in normothermic animals. A progressive rise of the CAR occurred during reoxygenation in the normothermic group whereas the ratio tended to decrease in the hypothermic group. In conclusion, post-hypoxic hypothermia attenuated NO production and overflow of EAAs.
doi_str_mv 10.1097/00001756-199710200-00033
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source MEDLINE; Journals@Ovid Complete
subjects Animals
Arginine - metabolism
Biochemistry and metabolism
Biological and medical sciences
Central nervous system
Cerebral Cortex - metabolism
Citrulline - metabolism
Electroencephalography
Excitatory Amino Acids - metabolism
Fundamental and applied biological sciences. Psychology
Hypothermia - metabolism
Hypoxia, Brain - metabolism
Medicin och hälsovetenskap
Microdialysis
Nitric Oxide - metabolism
Swine
Vertebrates: nervous system and sense organs
title Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins
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