Free and total prostate‐specific antigen serum concentrations do not help to detect prostate cancer in patients with urinary outlet obstruction
Objectives To determine whether different molecular forms of prostate‐specific antigen (PSA) obtained before transurethral resection of the prostate (TURP) indicate the presence of prostate cancer. Patients and methods The free, total and free‐to‐total PSA levels were measured in 261 patients sche...
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| Veröffentlicht in: | British Journal of Urology 1997-10, Vol.80 (4), p.618-622 |
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| container_title | British Journal of Urology |
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| creator | TRYGG, G. POUSETTE, Å. EKENGREN, J. HAHN, R.G. |
| description | Objectives
To determine whether different molecular forms of prostate‐specific antigen (PSA) obtained before transurethral resection of the prostate (TURP) indicate the presence of prostate cancer.
Patients and methods
The free, total and free‐to‐total PSA levels were measured in 261 patients scheduled for TURP, 20 of whom had known prostate cancer. The tissue histology was compared with the PSA levels and the patients were followed for 5 years.
Results
Prostate cancer was detected in 23 of the patients (9%) who were thought to have benign disease. Normal ranges for the distribution of the PSA levels were established based on the patients with a benign histology, but these ranges did not detect most of the unknown cancers. The sensitivity of the total PSA test in detecting cancer was 38% and the specificity 90%. The discrimination was no better when considering the free fraction or the free‐to‐total PSA level. However, none of the 14 patients whose cancer was missed showed general progression of the disease during the 5‐year follow‐up and only one died from prostate cancer. In contrast, eight of the 20 patients with a known prostatic malignancy showed general progression, and six died from the disease.
Conclusion
PSA testing of patients with outlet obstruction often failed to detect prostate cancer, but the prognosis was moderately good in those patients in whom it was missed. |
| doi_str_mv | 10.1046/j.1464-410X.1997.00423.x |
| format | Article |
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To determine whether different molecular forms of prostate‐specific antigen (PSA) obtained before transurethral resection of the prostate (TURP) indicate the presence of prostate cancer.
Patients and methods
The free, total and free‐to‐total PSA levels were measured in 261 patients scheduled for TURP, 20 of whom had known prostate cancer. The tissue histology was compared with the PSA levels and the patients were followed for 5 years.
Results
Prostate cancer was detected in 23 of the patients (9%) who were thought to have benign disease. Normal ranges for the distribution of the PSA levels were established based on the patients with a benign histology, but these ranges did not detect most of the unknown cancers. The sensitivity of the total PSA test in detecting cancer was 38% and the specificity 90%. The discrimination was no better when considering the free fraction or the free‐to‐total PSA level. However, none of the 14 patients whose cancer was missed showed general progression of the disease during the 5‐year follow‐up and only one died from prostate cancer. In contrast, eight of the 20 patients with a known prostatic malignancy showed general progression, and six died from the disease.
Conclusion
PSA testing of patients with outlet obstruction often failed to detect prostate cancer, but the prognosis was moderately good in those patients in whom it was missed.</description><identifier>ISSN: 0007-1331</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1046/j.1464-410X.1997.00423.x</identifier><identifier>PMID: 9352702</identifier><identifier>CODEN: BJURAN</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Disease Progression ; Humans ; Male ; Medical sciences ; Middle Aged ; mortality ; Nephrology. Urinary tract diseases ; Prognosis ; Prostate-Specific Antigen - blood ; prostate‐specific antigen ; Prostatic Hyperplasia - diagnosis ; prostatic hypertrophy ; Prostatic neoplasms ; Prostatic Neoplasms - diagnosis ; Sensitivity and Specificity ; Tumors of the urinary system ; Urinary Retention - etiology ; Urinary tract. Prostate gland</subject><ispartof>British Journal of Urology, 1997-10, Vol.80 (4), p.618-622</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4303-dd3722829d337c6e62225fce68b9c2eda80901b1683794a323f0e781d742fa823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1464-410X.1997.00423.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1464-410X.1997.00423.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2839794$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9352702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1940816$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>TRYGG, G.</creatorcontrib><creatorcontrib>POUSETTE, Å.</creatorcontrib><creatorcontrib>EKENGREN, J.</creatorcontrib><creatorcontrib>HAHN, R.G.</creatorcontrib><title>Free and total prostate‐specific antigen serum concentrations do not help to detect prostate cancer in patients with urinary outlet obstruction</title><title>British Journal of Urology</title><addtitle>Br J Urol</addtitle><description>Objectives
To determine whether different molecular forms of prostate‐specific antigen (PSA) obtained before transurethral resection of the prostate (TURP) indicate the presence of prostate cancer.
Patients and methods
The free, total and free‐to‐total PSA levels were measured in 261 patients scheduled for TURP, 20 of whom had known prostate cancer. The tissue histology was compared with the PSA levels and the patients were followed for 5 years.
Results
Prostate cancer was detected in 23 of the patients (9%) who were thought to have benign disease. Normal ranges for the distribution of the PSA levels were established based on the patients with a benign histology, but these ranges did not detect most of the unknown cancers. The sensitivity of the total PSA test in detecting cancer was 38% and the specificity 90%. The discrimination was no better when considering the free fraction or the free‐to‐total PSA level. However, none of the 14 patients whose cancer was missed showed general progression of the disease during the 5‐year follow‐up and only one died from prostate cancer. In contrast, eight of the 20 patients with a known prostatic malignancy showed general progression, and six died from the disease.
Conclusion
PSA testing of patients with outlet obstruction often failed to detect prostate cancer, but the prognosis was moderately good in those patients in whom it was missed.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prognosis</subject><subject>Prostate-Specific Antigen - blood</subject><subject>prostate‐specific antigen</subject><subject>Prostatic Hyperplasia - diagnosis</subject><subject>prostatic hypertrophy</subject><subject>Prostatic neoplasms</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Sensitivity and Specificity</subject><subject>Tumors of the urinary system</subject><subject>Urinary Retention - etiology</subject><subject>Urinary tract. Prostate gland</subject><issn>0007-1331</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1TAQhS0EKpfCIyB5gdgl-K9xIrGBivKjSmyoxM5y7An1JdcOtqPb7ngEeEWeBIcbZc3KI59vznh8EMKU1JSI5tW-pqIRlaDka027TtaECMbruwdotwkP0Y4QIivKOX2MnqS0J6SIjThDZx2_YJKwHfp9FQGw9hbnkPWIpxhS1hn-_PyVJjBucKao2X0DjxPE-YBN8AZ8jjq74BO2AfuQ8S2MU7HAFjKYvNlgowsdsfN4Kg2lL-Gjy7d4js7reI_DnEfIOPQpx9kslk_Ro0GPCZ6t5zm6uXr35fJDdf35_cfLN9eVEZzwylouGWtZZzmXpoGGMXYxGGjavjMMrG5JR2hPm5bLTmjO-EBAttRKwQbdMn6OqpNvOsI092qK7lBepIJ2ar36XipQgjcNaQv_8sSX3X7MkLI6uGRgHLWHMCclOy6FoKKA7Qk05RNShGGzpkQt6am9WkJSS0hqSU_9S0_dldbn64y5P4DdGte4iv5i1XUyehxi-V2XNoy1vCvLFuz1CTu6Ee7_e7x6--mmFPwvoUG6Fw</recordid><startdate>199710</startdate><enddate>199710</enddate><creator>TRYGG, G.</creator><creator>POUSETTE, Å.</creator><creator>EKENGREN, J.</creator><creator>HAHN, R.G.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>199710</creationdate><title>Free and total prostate‐specific antigen serum concentrations do not help to detect prostate cancer in patients with urinary outlet obstruction</title><author>TRYGG, G. ; POUSETTE, Å. ; EKENGREN, J. ; HAHN, R.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4303-dd3722829d337c6e62225fce68b9c2eda80901b1683794a323f0e781d742fa823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prognosis</topic><topic>Prostate-Specific Antigen - blood</topic><topic>prostate‐specific antigen</topic><topic>Prostatic Hyperplasia - diagnosis</topic><topic>prostatic hypertrophy</topic><topic>Prostatic neoplasms</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Sensitivity and Specificity</topic><topic>Tumors of the urinary system</topic><topic>Urinary Retention - etiology</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TRYGG, G.</creatorcontrib><creatorcontrib>POUSETTE, Å.</creatorcontrib><creatorcontrib>EKENGREN, J.</creatorcontrib><creatorcontrib>HAHN, R.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>British Journal of Urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TRYGG, G.</au><au>POUSETTE, Å.</au><au>EKENGREN, J.</au><au>HAHN, R.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free and total prostate‐specific antigen serum concentrations do not help to detect prostate cancer in patients with urinary outlet obstruction</atitle><jtitle>British Journal of Urology</jtitle><addtitle>Br J Urol</addtitle><date>1997-10</date><risdate>1997</risdate><volume>80</volume><issue>4</issue><spage>618</spage><epage>622</epage><pages>618-622</pages><issn>0007-1331</issn><eissn>1464-410X</eissn><coden>BJURAN</coden><abstract>Objectives
To determine whether different molecular forms of prostate‐specific antigen (PSA) obtained before transurethral resection of the prostate (TURP) indicate the presence of prostate cancer.
Patients and methods
The free, total and free‐to‐total PSA levels were measured in 261 patients scheduled for TURP, 20 of whom had known prostate cancer. The tissue histology was compared with the PSA levels and the patients were followed for 5 years.
Results
Prostate cancer was detected in 23 of the patients (9%) who were thought to have benign disease. Normal ranges for the distribution of the PSA levels were established based on the patients with a benign histology, but these ranges did not detect most of the unknown cancers. The sensitivity of the total PSA test in detecting cancer was 38% and the specificity 90%. The discrimination was no better when considering the free fraction or the free‐to‐total PSA level. However, none of the 14 patients whose cancer was missed showed general progression of the disease during the 5‐year follow‐up and only one died from prostate cancer. In contrast, eight of the 20 patients with a known prostatic malignancy showed general progression, and six died from the disease.
Conclusion
PSA testing of patients with outlet obstruction often failed to detect prostate cancer, but the prognosis was moderately good in those patients in whom it was missed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9352702</pmid><doi>10.1046/j.1464-410X.1997.00423.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1331 |
| ispartof | British Journal of Urology, 1997-10, Vol.80 (4), p.618-622 |
| issn | 0007-1331 1464-410X |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Disease Progression Humans Male Medical sciences Middle Aged mortality Nephrology. Urinary tract diseases Prognosis Prostate-Specific Antigen - blood prostate‐specific antigen Prostatic Hyperplasia - diagnosis prostatic hypertrophy Prostatic neoplasms Prostatic Neoplasms - diagnosis Sensitivity and Specificity Tumors of the urinary system Urinary Retention - etiology Urinary tract. Prostate gland |
| title | Free and total prostate‐specific antigen serum concentrations do not help to detect prostate cancer in patients with urinary outlet obstruction |
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