Intracellular Metabolism of the N7-Substituted Acyclic Nucleoside Analog 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a Potent Inhibitor of Herpesvirus Replication

We investigated the intracellular metabolism of S2242 (2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine), the only known antivirally active acyclic nucleoside analogue with the side chain substituted at the N7 position of the purine ring. Uptake of S2242 by CEM cells increased linearly with increasin...

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Veröffentlicht in:	Molecular pharmacology 1998-01, Vol.53 (1), p.157-165
Hauptverfasser:	Neyts, Johan, Balzarini, Jan, Andrei, Graciela, Chaoyong, Zhu, Snoeck, Robert, Zimmermann, Albert, Mertens, Thomas, Karlsson, Anna, De Clercq, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Alkaline Phosphatase - pharmacology Animals Antiviral Agents - metabolism Antiviral Agents - pharmacokinetics B-Lymphocytes - metabolism B-Lymphocytes - virology Carbon Radioisotopes Cell Line Cercopithecus aethiops Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - physiology Herpesvirus 6, Human - drug effects Herpesvirus 6, Human - physiology Humans Lung - cytology Lung - metabolism Lung - virology Mice Mice, Inbred C3H Nucleosides - pharmacology Phosphoric Diester Hydrolases - metabolism Phosphoric Diester Hydrolases - pharmacology Phosphorylation Purines - metabolism Purines - pharmacokinetics T-Lymphocytes - metabolism T-Lymphocytes - virology Vero Cells - metabolism Vero Cells - virology Virus Replication - drug effects
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