Expression and Distribution of Cytochrome P450 Enzymes in Male Rat Kidney: Effects of Ethanol, Acetone and Dietary Conditions

Ethanol, acetone, diet and starvation, known modulators of the hepatic cytochrome P450 (CYP)-dependent microsomal monooxygenase system, were assessed for their effects on cytochrome P450 isozyme content and monooxygenase activities in the male rat kidney. In acute experiments, rats were either treat...

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Veröffentlicht in:	Biochemical pharmacology 1998-01, Vol.55 (2), p.123-129
Hauptverfasser:	Ronis, Martin J.J, Huang, Jian, Longo, Vincenzo, Tindberg, Niclas, Ingelman-Sundberg, Magnus, Badger, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	acetone Acetone - pharmacology Alcoholism - enzymology Analytical, structural and metabolic biochemistry Animals Apoenzymes - biosynthesis Aryl Hydrocarbon Hydroxylases Biological and medical sciences Cytochrome P-450 CYP2E1 - biosynthesis Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - biosynthesis cytochrome P450 Diet Enteral Nutrition Enzymes and enzyme inhibitors ethanol Ethanol - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects kidney Kidney - enzymology Male Microsomes - enzymology Oxidoreductases Oxidoreductases, N-Demethylating - biosynthesis Rats Rats, Sprague-Dawley Starvation
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