Identification of two distinct deleted regions on chromosome 13 in prostate cancer

Aberrations of 13q occur frequently in prostate cancer and this chromosome contains two known tumor suppressor genes, BRCA2 and Rb1. This study analysed 13q LOH, DNA ploidy, BRCA2 mutation and pRb expression in prostate cancers. In total, 13q deletions were found in 18 of 36 tumors but did not corre...

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Veröffentlicht in:	Oncogene 1998-01, Vol.16 (4), p.481-487
Hauptverfasser:	CHUNDE LI, LARSSON, C, BERGERHEIM, U. S. R, FUTREAL, A, LANCASTER, J, PHELAN, C, ASPENBLAD, U, SUNDELIN, B, YIE LIU, EKMAN, P, AUER, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences BRCA2 protein Chromosome 13 Chromosomes, Human, Pair 13 - genetics Deoxyribonucleic acid DNA Gene Deletion Genes, Retinoblastoma - genetics Genes, Tumor Suppressor - genetics Gynecology. Andrology. Obstetrics Humans Loss of Heterozygosity Male Male genital diseases Medical sciences Medicin och hälsovetenskap Middle Aged Mutation Ploidies Ploidy Prostate cancer Prostatic Neoplasms - genetics Retinoblastoma Retinoblastoma Protein - metabolism Tetraploidy Tumor suppressor genes Tumors
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