Steroid Dependent Effects of Oxytocin on Spontaneous Motor Activity in Female Rats
In the present study, dose relationships for effects of oxytocin (OXY) on spontaneous motor activity in female rats were investigated. Ovariectomized (OVX) and cycling female Sprague-Dawley rats were given OXY 10–1000 μg/kg s.c. or saline, 10 min before registration of motor activity in an open-fiel...
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| Veröffentlicht in: | Brain research bulletin 1998-02, Vol.45 (3), p.301-305 |
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| creator | Petersson, Maria Ahlenius, Sven Wiberg, Ursula Alster, Pawel Uvnäs-Moberg, Kerstin |
| description | In the present study, dose relationships for effects of oxytocin (OXY) on spontaneous motor activity in female rats were investigated. Ovariectomized (OVX) and cycling female Sprague-Dawley rats were given OXY 10–1000 μg/kg s.c. or saline, 10 min before registration of motor activity in an open-field arena. In the OVX rats, 100 μg/kg of OXY increased the activity in the center of the arena, whereas 1000 μg/kg decreased locomotor activity (LA). In the cycling rats, OXY 100–1000 μg/kg decreased LA during diestrus, while 1000 μg/kg also decreased LA during metestrus. The latter dose also reduced the exploratory behavior during estrus. In a second experiment, OVX rats were pretreated with estradiol benzoate (EB) and progesterone (P). When P levels were predominant, OXY 10–1000 μg/kg decreased LA. Oxytocin 10–100 μg/kg given after pretreatment with EB increased the activity in the center of the arena, whereas 1000 μg/kg given in the presence of both EB and P increased peripheral activity (PA). These results show that the effects of OXY on motor activity in female rats are modified by female sex steroid hormones. |
| doi_str_mv | 10.1016/S0361-9230(97)00372-9 |
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Ovariectomized (OVX) and cycling female Sprague-Dawley rats were given OXY 10–1000 μg/kg s.c. or saline, 10 min before registration of motor activity in an open-field arena. In the OVX rats, 100 μg/kg of OXY increased the activity in the center of the arena, whereas 1000 μg/kg decreased locomotor activity (LA). In the cycling rats, OXY 100–1000 μg/kg decreased LA during diestrus, while 1000 μg/kg also decreased LA during metestrus. The latter dose also reduced the exploratory behavior during estrus. In a second experiment, OVX rats were pretreated with estradiol benzoate (EB) and progesterone (P). When P levels were predominant, OXY 10–1000 μg/kg decreased LA. Oxytocin 10–100 μg/kg given after pretreatment with EB increased the activity in the center of the arena, whereas 1000 μg/kg given in the presence of both EB and P increased peripheral activity (PA). These results show that the effects of OXY on motor activity in female rats are modified by female sex steroid hormones.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/S0361-9230(97)00372-9</identifier><identifier>PMID: 9510423</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Analysis of Variance ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Estradiol ; Estradiol - pharmacology ; Estrus - physiology ; Female ; Female rat ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; Locomotor activity ; Medicin och hälsovetenskap ; Motor Activity - drug effects ; Ovariectomy ; Ovary - physiology ; Oxytocin ; Oxytocin - pharmacology ; Progesterone ; Progesterone - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Brain research bulletin, 1998-02, Vol.45 (3), p.301-305</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-c3c4b484120bbec0fd99b90cc7107223f7ef91e8f561c388de793121e44e78bf3</citedby><cites>FETCH-LOGICAL-c572t-c3c4b484120bbec0fd99b90cc7107223f7ef91e8f561c388de793121e44e78bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0361-9230(97)00372-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2192318$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9510423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1945696$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Petersson, Maria</creatorcontrib><creatorcontrib>Ahlenius, Sven</creatorcontrib><creatorcontrib>Wiberg, Ursula</creatorcontrib><creatorcontrib>Alster, Pawel</creatorcontrib><creatorcontrib>Uvnäs-Moberg, Kerstin</creatorcontrib><title>Steroid Dependent Effects of Oxytocin on Spontaneous Motor Activity in Female Rats</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>In the present study, dose relationships for effects of oxytocin (OXY) on spontaneous motor activity in female rats were investigated. Ovariectomized (OVX) and cycling female Sprague-Dawley rats were given OXY 10–1000 μg/kg s.c. or saline, 10 min before registration of motor activity in an open-field arena. In the OVX rats, 100 μg/kg of OXY increased the activity in the center of the arena, whereas 1000 μg/kg decreased locomotor activity (LA). In the cycling rats, OXY 100–1000 μg/kg decreased LA during diestrus, while 1000 μg/kg also decreased LA during metestrus. The latter dose also reduced the exploratory behavior during estrus. In a second experiment, OVX rats were pretreated with estradiol benzoate (EB) and progesterone (P). When P levels were predominant, OXY 10–1000 μg/kg decreased LA. Oxytocin 10–100 μg/kg given after pretreatment with EB increased the activity in the center of the arena, whereas 1000 μg/kg given in the presence of both EB and P increased peripheral activity (PA). These results show that the effects of OXY on motor activity in female rats are modified by female sex steroid hormones.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Estradiol</subject><subject>Estradiol - pharmacology</subject><subject>Estrus - physiology</subject><subject>Female</subject><subject>Female rat</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>Locomotor activity</subject><subject>Medicin och hälsovetenskap</subject><subject>Motor Activity - drug effects</subject><subject>Ovariectomy</subject><subject>Ovary - physiology</subject><subject>Oxytocin</subject><subject>Oxytocin - pharmacology</subject><subject>Progesterone</subject><subject>Progesterone - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1EVbaFn1DJB4TgEOqvxPEJVaUtSK0qdeFsOc5YMmTjYHsL--9xm7Ccqp5seZ53ZuQHoRNKPlJCm9M14Q2tFOPkvZIfCOGSVeoFWtFW8opJIV-i1R55hY5S-kEIadq6OUSHqqZEML5Cd-sMMfgef4YJxh7GjC-cA5sTDg7f_tnlYP2Iw4jXUxizGSFsE74JOUR8ZrO_93mHC3AJGzMAvjM5vUYHzgwJ3iznMfp-efHt_Et1fXv19fzsurK1ZLmy3IpOtIIy0nVgieuV6hSxVlIiGeNOglMUWlc31PK27UEqThkFIUC2nePHqJr7pt8wbTs9Rb8xcaeD8Xp5-lluoAWvhRCFl0_yUwz9_9C_IFWiblRTku_mZMF-bSFlvfHJwjDM36Glkrxhkj4L0kYoJkhdwHoGbQwpRXD7bSjRD3r1o1794E4rqR_1alVyJ8uAbbeBfp9afJb626VukjWDi2a0Pu0xRktD2hbs04xB8XPvIepkPYwWeh-Le90H_8wifwHtbsJC</recordid><startdate>19980201</startdate><enddate>19980201</enddate><creator>Petersson, Maria</creator><creator>Ahlenius, Sven</creator><creator>Wiberg, Ursula</creator><creator>Alster, Pawel</creator><creator>Uvnäs-Moberg, Kerstin</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19980201</creationdate><title>Steroid Dependent Effects of Oxytocin on Spontaneous Motor Activity in Female Rats</title><author>Petersson, Maria ; Ahlenius, Sven ; Wiberg, Ursula ; Alster, Pawel ; Uvnäs-Moberg, Kerstin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-c3c4b484120bbec0fd99b90cc7107223f7ef91e8f561c388de793121e44e78bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Estradiol</topic><topic>Estradiol - pharmacology</topic><topic>Estrus - physiology</topic><topic>Female</topic><topic>Female rat</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and behavior</topic><topic>Locomotor activity</topic><topic>Medicin och hälsovetenskap</topic><topic>Motor Activity - drug effects</topic><topic>Ovariectomy</topic><topic>Ovary - physiology</topic><topic>Oxytocin</topic><topic>Oxytocin - pharmacology</topic><topic>Progesterone</topic><topic>Progesterone - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petersson, Maria</creatorcontrib><creatorcontrib>Ahlenius, Sven</creatorcontrib><creatorcontrib>Wiberg, Ursula</creatorcontrib><creatorcontrib>Alster, Pawel</creatorcontrib><creatorcontrib>Uvnäs-Moberg, Kerstin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petersson, Maria</au><au>Ahlenius, Sven</au><au>Wiberg, Ursula</au><au>Alster, Pawel</au><au>Uvnäs-Moberg, Kerstin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steroid Dependent Effects of Oxytocin on Spontaneous Motor Activity in Female Rats</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1998-02-01</date><risdate>1998</risdate><volume>45</volume><issue>3</issue><spage>301</spage><epage>305</epage><pages>301-305</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>In the present study, dose relationships for effects of oxytocin (OXY) on spontaneous motor activity in female rats were investigated. Ovariectomized (OVX) and cycling female Sprague-Dawley rats were given OXY 10–1000 μg/kg s.c. or saline, 10 min before registration of motor activity in an open-field arena. In the OVX rats, 100 μg/kg of OXY increased the activity in the center of the arena, whereas 1000 μg/kg decreased locomotor activity (LA). In the cycling rats, OXY 100–1000 μg/kg decreased LA during diestrus, while 1000 μg/kg also decreased LA during metestrus. The latter dose also reduced the exploratory behavior during estrus. In a second experiment, OVX rats were pretreated with estradiol benzoate (EB) and progesterone (P). When P levels were predominant, OXY 10–1000 μg/kg decreased LA. Oxytocin 10–100 μg/kg given after pretreatment with EB increased the activity in the center of the arena, whereas 1000 μg/kg given in the presence of both EB and P increased peripheral activity (PA). These results show that the effects of OXY on motor activity in female rats are modified by female sex steroid hormones.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9510423</pmid><doi>10.1016/S0361-9230(97)00372-9</doi><tpages>5</tpages></addata></record> |
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| ispartof | Brain research bulletin, 1998-02, Vol.45 (3), p.301-305 |
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| subjects | Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences Dose-Response Relationship, Drug Estradiol Estradiol - pharmacology Estrus - physiology Female Female rat Fundamental and applied biological sciences. Psychology Hormones and behavior Locomotor activity Medicin och hälsovetenskap Motor Activity - drug effects Ovariectomy Ovary - physiology Oxytocin Oxytocin - pharmacology Progesterone Progesterone - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley |
| title | Steroid Dependent Effects of Oxytocin on Spontaneous Motor Activity in Female Rats |
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